4. Responsibilities in research practice

1. 4.1.1.  CR-UK does not act as an employer with respect to the Grant, and therefore, in all cases where support is provided by the Grant for the employment of staff, the Host Institution or its permitted subcontractor(s) must issue a contract of employment for such staff in compliance with the relevant laws and regulations1.
2. 4.1.2.  All clinical staff appointed on grants should hold honorary NHS clinical contracts or honorary university contracts at the appropriate level. The Host Institution is responsible for ensuring all clinical staff have the necessary professional registration and occupational health clearance. CR-UK accepts no liability for any claim arising out of matters relating to fitness of practice.
3. 4.1.3.  CR-UK will not be responsible for, nor will it indemnify the Host Institution against, any claim for redundancy, compensation, dismissal or discrimination or any other claims for which the Host Institution or any permitted sub-contractor may be liable as an employer or otherwise.
4. 4.1.4.  The Host Institution must ensure that all permanent and temporary staff and students employed or involved in the work funded by the Grant receive training appropriate to their duties, in accordance with any applicable legal or regulatory requirements. This includes management and leadership training and development for all CR-UK supported staff with managerial responsibilities.
5. 4.1.5.  The Host Institution must ensure that appropriate Premises are available to house the Research Personnel and all equipment used in the Research is fully maintained, kept in an appropriate and safe state of repair and properly serviced for the duration of the Grant. The Host Institution must comply with and perform all obligations and duties at law (including all health and safety legislation) in respect of the Premises.
6. 4.1.6.  The Host Institution must identify any risks which could affect the health of new and expectant mothers and must take any actions necessary as a result of the risk assessment.
7. 4.1.7.  Researchers in receipt of salary support from CR-UK must ensure that their time commitments to commercial organisations and other non-research activities are compatible with the policies of the institution and any conditions in the Grant Award Letter.
8. 4.1.8.  CR-UK funded researchers must disclose to their institutions (a) benefits in cash in excess of £10 000 per annum or (b) benefits in equity of any level, received either as compensation for work undertaken for a commercial organisation, or in consideration of the transfer of intellectual property.
9. 4.1.9.  In managing a perceived or actual conflict of interest, the institution must use all reasonable endeavours to ensure that CR-UK is not put at risk of being in breach of charity law or regulation because of the relationship of a CR-UK funded researcher with a commercial organisation. In particular, the institution should act to ensure that the useful results of CR-UK funded research are applied for the public benefit, with only incidental private benefit. This might involve requiring a CR-UK funded researcher to relinquish direct control over some, or all, of the assets they hold in a commercial organisation or requiring the level of compensation offered to the CR-UK funded researcher to be capped.

1 In exceptional and specific circumstances, a Grant may include support costs for CR-UK staff working within the Host Institution. Such staff will remain CR-UK employees.

1. 4.2.1.  It is the responsibility of the Host Institution and Grantholder to ensure that all parties, including collaborators, supervisors, and staff employed on CR-UK grants comply with the terms and conditions.
2. 4.2.2.  The Host Institution must hold appropriate policies of insurance covering personal indemnity, public liability, and employer’s liability and shall maintain such insurance policies throughout the Project and any commercialisation of the Results.
3. 4.2.3.  The Host Institution must ensure proper financial management of grants and accountability for the use of public funds.
4. 4.2.4.  The Host Institution must ensure that the Grant is used for the purposes for which it was awarded. Any plan to diverge from the aims outlined in the original grant application requires prior written agreement from CR-UK. In the event the research is terminated early, CR-UK must be notified in writing.
5. 4.2.5.  The Host Institution must ensure that adequate resources are provided to support the activities and timeframe described in the GAL.
6. 4.2.6.  The Host Institution must notify CR-UK if there is any change in status, or of Research Personnel, that may affect its eligibility to hold the grant.
7. 4.2.7.  The Host Institution will inform CR-UK promptly of any pre-existing arrangements which may lead to a breach of the Grant Conditions. The Host Institution shall not enter into, or permit any person involved with the project to enter into, consultancies, third party restrictions or arrangements which may affect the Research without the prior written agreement of CR-UK.
8. 4.2.8.  The Host Institution and the Grantholder must notify any commercial collaborators of the application and obtain their agreement for the disclosure of confidential information.
9. 4.2.9.  CR-UK’s DDO must be notified of any potential new treatment arising from a CR-UK Grant. It is expected that the CR-UK New Agents Committee will be the preferred route for clinical testing of any potential new treatment.
10. 4.2.10.  CR-UK acknowledges that the Host Institution is subject to the Freedom of Information Act 2000. If the Host Institution receives a 'Request for Information' in respect to any part of the Grant, the Host Institution must notify and consult with CR-UK on the response to the request.

1. 4.3.1.  The Host Institution must have in place formal written procedures for the handling of allegations of research misconduct. The procedure(s) must include guidance or a code of practice on standards of professional behaviour, provisions for induction and training of staff, monitoring, resolutions and procedures for handling allegations and fair procedures and appropriate protection for both the accused and any ‘whistleblower’. The procedure(s) must be made available to CR-UK upon request.
2. 4.3.2.  It is the responsibility of the Host Institution to inform CR-UK, in confidence, at the earliest opportunity, about allegations, progress of the investigation and the investigation outcome of research misconduct that concern Researchers.
3. 4.3.3.  CR-UK reserves the right to investigate any aspect of fraud or misconduct itself as it reasonably sees fit and the Host Institution shall provide assistance and information to CR-UK for that purpose.
4. 4.3.4.  The Host Institution is responsible for managing conflicts of interests ensuring:
   1. Any relationship between the Host Institution, Researchers and commercial organisations shall be appropriate and not unduly benefit the commercial organisation or influence the research
   2. Any form of remuneration by a company for consultancy shall be made only for the appropriate provision of advice and the exchange of ideas and shall not enable that organisation to gain inappropriate access to Funded Intellectual Property
   3. CR-UK is notified of any conflicts which may be relevant to the research.

1. 4.4.1.  The Host Institution must ensure that before the research funded by the Grant commences and during the full Grant Period, all the necessary legal and regulatory requirements, including any necessary or appropriate ethical approval, in order to conduct the research are met. This includes obtaining all licences and approvals. The Host Institution accepts full responsibility for ensuring that any such approvals are in place at all relevant periods of the Grant.
2. 4.4.2.  The Grantholder and Research Personnel must adhere to the 'Guidelines for the welfare and use of animals in cancer research' as set out by Workman et al (2010) (British Journal of Cancer 102, 1555-1577). The Grant must not be used for any research on animals which has not been approved and set out in the grant application.

1. 4.5.1.  Grantholders are expected to respond positively and punctually to requests to referee CR-UK grant applications.