Selected Publications
Gilligan, M.G., Knox, P., Weedon, S., Barton,
R., Kerr, D.J., Searle. P. & Young, L.S. (1998). Adenoviral delivery
of B7.1 (CD80) increases the immunogenicity of human ovarian and cervical
carcinoma cells. Gene Therapy 5, 965-974.
S. J. Weedon, N. K. Green, I. A. McNeish, M. G. Gilligan, V. Mautner,
C. J. Wrighton, A. Mountain, L. S. Young, D. J. Kerr & P. F. Searle
(2000). Sensitisation of human carcinoma cells to the prodrug CB1954 by
adenovirus vector-mediated expression of E. coli nitroreductase. International
Journal of Cancer 86, 848-854.
Irvine, A.S., Trinder, P.K.E., Laughton, D.L., Ketteringham, H., McDermott,
R.H., Reid, S.C.H., Haines, A.M.R., Amir, A., Husain, R., Doshi, R., Young,
L.S. and Mountain, A. (2000). Efficient, non-viral transfection of
dendritic cells: immune responses and anti-tumour effects. Nat. Biotech.
18, 1273-1278.
Chapman, A.L.N., Rickinson, A.B., Thomas, W.A., Jarrett, R.F., Crocker,
J. and Lee, S.P. (2001). Epstein-Barr virus-specific cytotoxic T lymphocyte
responses in the blood and tumour site of Hodgkin's disease patients:
implications for a T cell-based therapy. Cancer Res. 61, 6219-6226.
Lipinski, K.S., Djeha, A.H., Ismail, T., Mountain, A., Young, L.S.
and Wrighton, C.J. (2001) High level, catenin/TCF-dependent transgene
expression in secondary colorectal cancer tissue. Mol. Therapy
4, 365-371.
Eliopoulos, A.G. and Young, L.S. (1998) Activation of the cJun
N-terminal kinase (JNK) pathway by the Epstein-Barr virus-encoded latent
membrane protein 1 (LMP1). Oncogene 16, 1731-1742.
Eliopoulos, A.G., Blake, S.M.S., Floettmann, J.E., Rowe, M. & Young,
L.S. (1999) Epstein-Barr virus-encoded latent membrane protein 1 activates
the JNK pathway through its extreme C-terminus via a mechanism involving
TRADD and TRAF2. J. Virol. 73, 1023-1035.
Eliopoulos, A.G., Gallagher, N.J., Blake, S.M.S., Dawson, C.W. and
Young, L.S. (1999) Activation of the p38 MAPK pathway by Epstein-Barr
virus-encoded latent membrane protein 1 (LMP1) co-regulates interleukin-6
and interleukin-8 production. J. Biol. Chem. 274, 16085-16096.
Murray, P.G., Billingham, L.J., Hassan, H.T., Flavell, J.R., Nelson,
P.N., Scott, K., Constandinou, C.M., Kerr, D.J., Devey, E.C., Crocker,
J. & Young, L.S. (1999) Effect of Epstein-Barr virus infection
on response to chemotherapy and survival in Hodgkin's disease. Blood
94, 442-447.
Dawson, C.W., George, J.H., Blake, S.M.S., Longnecker, R. and Young,
L.S. (2001) The Epstein-Barr virus encoded latent membrane protein
2A augments signaling from latent membrane protein 1. Virology
289,192-207.
