Selected Publications

Davis AA, Masson J, Mcllwraith MJ, Stasiak AZ, Stasiak A, Venkitaraman AR, West SC. Role of BRCA2 in Control of the RAD51 Recombination and DNA Repair Protein. Molecular Cell 2001; 7: 273-282.

Yu VPCC, Koehler M, Steinlein C, Schmid M, Hanakahi LA, van Gool AJ, West SC, Venkitaraman AR. Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation. Genes & Development 2000; 14: 1400-1406.

Lee H, Trainer AH, Friedman LS, Thistlewaite FC, Evans MJ, Ponder BJ, Venkitaraman AR. Mitotic Checkpoint Inactivation Fosters Transformation in Cells Lacking the Breast Cancer Susceptibility Gene, BRCA2. Molecular Cell 1999; 4: 1-10.

Patel KJ, Yu VPCC, Lee H, Corcoran A, Thistlewaite FC, Evans MJ, Colledge WH, Friedman LS, Ponder BJ, Venkitaraman AR. Involvement of Brca2 in DNA Repair. Molecular Cell 1998; 1: 347-357.

Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature 1998; 391: 904-907.

2004

Daniels MJ, Marson A and Venkitaraman AR. PML bodies control the nuclear dynamics and function of the CHFR mitotic checkpoint protein. Nature Structural & Molecular Biology 2004; (in press).

Daniels MJ, Wang Y, Lee M and Venkitaraman AR. Abnormal Cytokinesis in Cells Deficient in the Breast Cancer Susceptibility Protein BRCA2. Science 2004; (in press).

Venkitaraman AR. Tracing the network connecting the BRCA and Fanconi Anaemia proteins. Nature Review Cancer 2004; 4: 266-276.

Lee M, Daniels MJ and Venkitaraman AR. Phosphorylation of BRCA2 by the Polo-kinase Plk1 is regulated by DNA damage and mitotic progression. Oncogene 2004; 23: 865-872.

2003

Lomonosov M, Anand S, Sangrithi M, Davies R, Venkitaraman, AR. Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein. Genes & Development 2003; 17: 3017-22.

Yu DS, Sonoda, E, Takeda S, Huang LH, Venkitaraman AR. Dynamic Control of Rad51 Recombinase by Self-Association and Interaction with BRCA2. Molecular Cell 2003; 12: 1029-41.

Shin DS, Pellegrini L, Daniels DS, Yelent B, Craig L, Bates D, Yu DS, Shivji MK, Hitomi D, Arvai AS, Volkmann N, Tsuruta H, Blundell TL, Venkitaraman AR, Tainer JA. Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2. EMBO 2003; 22(17): 4566-4576.

Venkitaraman AR. A Growing Network of Cancer-Susceptibility Genes. New England Journal of Medicine 2003; 348(19): 1917-19.

Anand S, Penrhyn-Lowe S, Venkitaraman AR. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 2003; 3: 51-62.

Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin S-F, Milner J, Brown, LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragas J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman AR, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T. EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer. Cell 2003; 115: 523-545.

2002

Pellegrini L, Yu DS, Lo T, Anand S, Lee M, Blundell T, Venkitaraman AR. Insights into DNA recombination from the stucture of a RAD51-BRCA2 complex. Nature 2002; 420:287-93.

Venkitaraman AR. Cancer Susceptibility and the Functions of BRCA1 and BRCA2. Cell 2002; 108: 171-182.