Cancer Research UK Grants & Research: Kevin Brindle

Selected Publications

Gallagher FA, Kettunen MI, Day SE, Hu D-E, Ardenkjær-Larsen JH, Zandt R, Jensen PR, Karlsson M, Golman K, Lerche MH, Brindle KM. Magnetic resonance imaging of pH in vivo using hyperpolarized ¹³C-labelled bicarbonate. Nature 2008; 453: 940-943. PubMed

Krishnan AS, Neves AA, de Backer MM, Hu DE, Davletov B, Kettunen MI, Brindle KM. Detection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent. Radiology 2008; 246(3):854-862. PubMed

Neves AA, Krishnan AS, Kettunen MI, Hu DE, de Backer MM, Davletov B, Brindle KM. A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging. Nano Lett 2007; 7(5):1419-1423. PubMed

Day SE, Kettunen MI, Gallagher FA, Hu DE, Lerche M, Wolber J, Golman K, Ardenkjaer-Larsen JH, Brindle KM. Detecting tumor response to treatment using hyperpolarized ¹³C magnetic resonance imaging and spectroscopy. Nat Med 2007; 13(11):1382-1387. PubMed

Bundy JG, Iyer NG, Gentile MS, Hu DE, Kettunen M, Maia AT, Thorne NP, Brenton JD, Caldas C, Brindle KM. Metabolic consequences of p300 gene deletion in human colon cancer cells. Cancer Res 2006; 66(15):7606-7614. PubMed

Primary Research Publications

2008

Gallagher FA, Kettunen MI, Day SE, Lerche MH, Brindle KM. ¹³C MR spectroscopy measurements of glutaminase activity in human hepatocellular carcinoma using hyperpolarised ¹³C-labelled glutamine. Magnetic Resonance Medicine 2008; 60:253-7

Krishnan AS, Neves AA, de Backer MM, Hu DE, Davletov B, Kettunen MI, Brindle KM. Detection of cell death in tumours by using MR imaging and a gadolinium-based targeted contrast agent. Radiology 2008; 246:854-62

2007

Browne RA, Brindle KM. H-1 NMR-based metabolite profiling as a potential selection tool for breeding passive resistance against Fusarium head blight (FHB) in wheat. Mol Plant Pathol 2007; 8(4):401-410

Bundy JG, Papp B, Harmston R, Browne RA, Clayson EM, Burton N, Reece RJ, Oliver SG, Brindle KM. Evaluation of predicted network modules in yeast metabolism using NMR-based metabolite profiling. Genome Res 2007; 17(4):510-519

Day SE, Kettunen MI, Gallagher FA, Hu DE, Lerche M, Wolber J, Golman K, Ardenkjaer-Larsen JH, Brindle KM. Detecting tumor response to treatment using hyperpolarized C-13 magnetic resonance imaging and spectroscopy. Nat Med 2007; 13(11):1382-1387

Fang W, Wang F, Ji S, Zhu X, Meier HT, Hellman RS, Brindle KM, Davletov B, Zhao M. SPECT imaging of myocardial infarction using Tc-99m-labeled C2A domain of synaptotagmin I in a porcine ischemia-reperfusion model. Nucl Med Biol 2007; 34(8):917-923

Neves AA, Krishnan AS, Kettunen MI, Hu DE, de Backer MM, Davletov B, Brindle KM. A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging. Nano Lett 2007; 7(5):1419-1423

2006

Dunning MD, Kettunen MI, Constant CF, Franklin RJM, Brindle KM. Magnetic resonance imaging of functional Schwann cell transplants labelled with magnetic microspheres. Neuroimage 2006; 31(1):172-180

Kirschenlohr HL, Griffin JL, Clarke SC, Rhydwen R, Grace AA, Schofield PM, Brindle KM, Metcalfe JC. Proton NMR analysis of plasma is a weak predictor of coronary artery disease. Nat Med 2006; 12(6):705-710

Neves AA, Medcalf N, Smith M, Brindle KM. Evaluation of engineered meniscal cartilage constructs based on different scaffold geometries using magnetic resonance imaging and spectroscopy. Tissue Eng 2006; 12(1):53-62

2005

Botchway SW, Barba I, Jordan R, Harmston R, Haggie PM, William SP, Fulton AM, Parker AW, Brindle KM. A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging. Biochem J 2005; 390(Pt 3):787-790

Bundy JG, Willey TL, Castell RS, Ellar DJ, Brindle KM. Discrimination of pathogenic clinical isolates and laboratory strains of Bacillus cereus by NMR-based metabolomic profiling. FEMS Microbiol Lett 2005; 242(1):127-136

Hu DE, Brindle KM. Immune cell-induced synthesis of NO and reactive oxygen species in lymphoma cells causes their death by apoptosis. FEBS Lett 2005; 579(13):2833-2841

Hu DE, Kettunen MI, Brindle KM. Monitoring T-lymphocyte trafficking in tumors undergoing immune rejection. Magn Reson Med 2005; 54(6):1473-1479

Leach MO, Brindle KM, Evelhoch JL, Griffiths JR, Horsman MR, Jackson A, Jayson GC, Judson IR, Knopp MV, Maxwell RJ, McIntyre D, Padhani AR, Price P, Rathbone R, Rustin GJ, Tofts PS, Tozer GM, Vennart W, Waterton JC, Williams SR, Workman P. The assessment of antiangiogenic and antivascular therapies in early-stage clinical trials using magnetic resonance imaging: issues and recommendations. Br J Cancer 2005; 92(9):1599-1610

Medina-Gomez G, Virtue S, Lelliott C, Boiani R, Campbell M, Christodoulides C, Perrin C, Jimenez-Linan M, Blount M, Dixon J, Zahn D, Thresher RR, Aparicio S, Carlton M, Colledge WH, Kettunen MI, Seppanen-Laakso T, Sethi JK, O'Rahilly S, Brindle K, Cinti S, Oresic M, Burcelin R, Vidal-Puig A. The link between nutritional status and insulin sensitivity is dependent on the adipocyte-specific peroxisome proliferator-activated receptor-gamma 2 isoform. Diabetes 2005; 54(6):1706-1716

Neves AA, Medcalf N, Brindle KM. Influence of stirring-induced mixing on cell proliferation and extracellular matrix deposition in meniscal cartilage constructs based on polyethylene terephthalate scaffolds. Biomaterials 2005; 26(23):4828-4836

Schmitz JE, Kettunen MI, Hu DE, Brindle KM. H-1 MRS-visible lipids accumulate during apoptosis of lymphoma cells in vitro and in vivo. Magn Reson Med 2005; 54(1):43-50

2004

Dunning MD, Lakatos A, Loizou L, Kettunen M, ffrench-Constant C, Brindle KM, Franklin RJM. Superparamagnetic iron oxide-labeled Schwann cells and olfactory ensheathing cells can be traced in vivo by magnetic resonance imaging and retain functional properties after transplantation into the CNS. J Neurosci 2004; 24(44):9799-9810

Hu DE, Dyke SOM, Moore AM, Thomsen LL, Brindle KM. Tumor cell-derived nitric oxide is involved in the immune-rejection of an immunogenic murine lymphoma. Cancer Res 2004; 64(1):152-161

Hu DE, Moore AM, Thomsen LL, Brindle KM. Uric acid promotes tumor immune rejection. Cancer Res 2004; 64(15):5059-5062

Iyer NG, Chin SF, Ozdag H, Daigo Y, Hu DE, Cariati M, Brindle K, Aparicio S, Caldas C. P300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. Proc Natl Acad Sci U S A 2004; 101(19):7386-7391

Jung HI, Kettunen MI, Davletov B, Brindle KM. Detection of apoptosis using the C2A domain of synaptotagmin I. Bioconjug Chem 2004; 15(5):983-987

2003

Brindle KM. Molecular imaging using magnetic resonance: new tools for the development of tumour therapy. Br J Radiol 2003; 76(Spec Iss):S111-S117

Hu DE, Beauregard DA, Bearchell MC, Thomsen LL, Brindle KM. Early detection of tumour immune-rejection using magnetic resonance imaging. Br J Cancer 2003; 88(7):1135-1142

Neves AA, Medcalf N, Brindle K. Functional assessment of tissue-engineered meniscal cartilage by magnetic resonance imaging and spectroscopy. Tissue Eng 2003; 9(1):51-62

2002

Beauregard DA, Pedley RB, Hill SA, Brindle KM. Differential sensitivity of two adenocarcinoma xenografts to the anti-vascular drugs combretastatin A4 phosphate and 5,6-dimethylxanthenone-4-acetic acid, assessed using MRI and MRS. NMR Biomed 2002; 15(2):99-105

Brennan L, Shine A, Hewage C, Malthouse JPG, Brindle KM, McClenaghan N, Flatt PR, Newsholme P. A nuclear magnetic resonance-based demonstration of substantial oxidative L-alanine metabolism and L-alanine-enhanced glucose metabolism in a clonal pancreatic beta-cell line - Metabolism of L-alanine is important to the regulation of insulin secretion. Diabetes 2002; 51(6):1714-1721

Griggs J, Skepper JN, Smith GA, Brindle KM, Metcalfe JC, Hesketh R. Inhibition of proliferative retinopathy by the anti-vascular agent combretastatin-A4. Am J Pathol 2002; 160(3):1097-1103

Harper JA, Stuart JA, Jekabsons MB, Roussel D, Brindle KM, Dickinson K, Jones RB, Brand MD. Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria. Biochem J 2002; 361(Pt 1):49-56

Neves AA, Medcalf N, Brindle KM. Tissue engineering of meniscal cartilage using perfusion culture. Ann N Y Acad Sci 2002; 961:352-355

Other Publications

Brindle KM. New approaches for imaging tumour responses to treatment. Nature Reviews Cancer 2008; 8:94-107

Neves AA, Brindle KM. Assessing responses to cancer therapy using molecular imaging. Biochim Biophys Acta [Rev Cancer] 2006; 1766(2):242-261

Kettunen MI, Brindle KM. Apoptosis detection using magnetic resonance imaging and spectroscopy. Prog Nucl Magn Reson Spectrosc 2005; 47(3-4):175-185

Brindle KM. Magnetic cells show the way home. Blood 2003; 102(3):776-776

Hakumaki JM, Brindle KM. Techniques: Visualizing apoptosis using nuclear magnetic resonance. Trends Pharmacol Sci 2003; 24(3):146-149

Leach MO, Brindle KM, Evelhoch JL, Griffiths JR, Horsman MR, Jackson A, Jayson G, Judson IR, Knopp MV, Maxwell RJ, McIntyre D, Padhani AR, Price P, Rathbone R, Rustin G, Tofts PS, Tozer GM, Vennart W, Waterton JC, Williams SR, Workman P. Assessment of antiangiogenic and antivascular therapeutics using MRI: recommendations for appropriate methodology for clinical trials. Br J Radiol 2003; 76(Spec Iss):S87-S91

Brindle KM. Detection of apoptosis in tumors using magnetic resonance imaging and spectroscopy. Adv Enzyme Regul 2002; 42:101-112

Brindle KM. Special issue: Assessing tumor vascular function using magnetic resonance imaging. NMR Biomed 2002; 15(2):87-88