Selected Publications

Ozdag H, Teschendorff AE, Ahmed AA, Hyland SJ, Blenkiron C, Bobrow L, Veerakumarasivam A, Burtt G, Subkhankulova T, Arends MJ, Collins VP, Bowtell D, Kouzarides T, Brenton JD and Caldas C. Differential expression of selected histone modifier genes in human solid cancers. BMC Genomics 2006; 7: 90. PubMed PDF (in UKPMC)

Callagy GM, Pharoah PD, Pinder SE, Hsu FD, Nielsen TO, Ragaz J, Ellis IO, Huntsman D and Caldas C. Bcl-2 is a prognostic marker in breast cancer independently of the Nottingham Prognostic Index (NPI). Clin Cancer Res 2006; 12: 2468-2475. PubMed

Garcia MJ, Pole JCM, Chin S-F, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PAW and Caldas C. A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. Oncogene 2005; 24: 5235-5245. PubMed

Iyer NG, Chin S-F, Ozdag H, Daigo Y, Hu D-E, Cariati M, Brindle K, Aparicio S and Caldas C. p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/ p21 levels. Proc Natl Acad Sci USA 2004; 101: 7386-7391. PubMed PDF (in UKPMC)

Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin S-F, Milner J, Brown LA, Hsu F, Gliks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C and Kouzarides T. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 2003; 115: 523-535. PubMed

Primary Research Publications

2008

Azzato EM, Driver KE, Lesueur F, Shah M, Greenberg D, Easton DF, Teschendorff AE, Caldas C, Caporaso NE, Pharoah PD. Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. Breast Cancer Research 2008; 10:R47

Barber ME, Save V, Carneiro F, Dwerryhouse S, Lao-Sirieix P, Hardwick RH, Caldas C, Fitzgerald RC. Histopathological and molecular analysis of gastrectomy specimens from hereditary diffuse gastric cancer patients has implications for endoscopic surveillance of individuals at risk. The Journal of Pathology 2008; 216:286-294

Barber ME, Murrell A, Ito Y, Maia A-T, Hyland S, Oliveira C, Save V, Carneiro F, Paterson AL, Grehan N, Dwerryhouse S, Lao-Sirieix P, Caldas C, Fitzgerald RC. Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer. The Journal of Pathology 2008; 216:295-306

Brown LA, Hoog J, Chin S-F, Tao Y, Zayed AA, Chin K, Teschendorff AE, Quackenbush JF, Marioni JC, Leung S, Perou CM, Neilsen TO, Ellis M, Gray JW, Bernard PS, Huntsman DG, Caldas C. ESR1 gene amplification in breast cancer: a common phenomenon? Nature Genetics. 2008; 40:806-7

Callagy GM, Webber MJ, Pharoah PD, Caldas C. Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer. BMC Cancer 2008; 8:153

Capell´ G, Pera G, Sala N, Agudo A, Rico F, Del Giudicce G, Plebani M, Palli D, Boeing H, Bueno-de-Mesquita HB, Carneiro F, Berrino F, Vineis P, Tumino R, Panico S, Berglund G, Sim´n H, Nyr&ecute;n O, Hallmans G, Martinez C, Dorronsoro M, Barricarte A, Navarro C, Quir&ocute;s JR, Allen N, Key T, Bingham S, Caldas C, Linseisen J, Nagel G, Overvad K, Tjonneland A, Boshuizen HC, Peeters PH, Numans ME, Clavel-Chapelon F, Trichopoulou A, Lund E, Jenab M, Kaaks R, Riboli E, Gonz´lez CA. DNA repair polymorphisms and the risk of stomach adenocarcinoma and severe chronic gastritis in the EPIC-EURGAST study. International Journal of Epidemiology 2008; 37:1316-25

Cariati M, Naderi A, Brown JP, Smalley MJ, Pinder SE, Caldas C, Purushotham AD. Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line. International Journal of Cancer 2008; 122:298-304

Cooke SL, Pole JC, Chin SF, Ellis IO, Caldas C, Edwards PA. High-resolution array CGH clarifies events occurring on 8p in carcinogenesis. BMC Cancer 2008; 8:288

Crusius JBA, Canzian F, Capell´ G, Peña AS, Pera G, Sala N, Agudo A, Rico F, Del Giudice G, Palli D, Plebani M, Boeing H, Bueno de Mesquita HB, Carneiro F, Pala V, Save VE, Vineis P, Tumino R, Panico S, Berglund G, Manjer J, Stenling R, Hallmans G, Martínez C, Dorronsoro M, Barricarte A, Navarro C, Quir&ocute;s JR, Allen N, Key TJ, Binghan S, Caldas C, Linseisen J, Kaaks R, Overvad K, Tjønneland A, Büchner FC, Peeters PHM, Numans ME, Clavel-Chapelon F, Trichopoulou A, Lund E, Jenab M, Rinaldi S, Ferrari P, Riboli E, Gonz´lez CA. Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST) Annals of Oncology 2008; 19:1894-1902

Git A, Spiteri I, Blenkiron C, Dunning M, Pole JC, Chin S-F, Wang Y, Smith J, Livesey FJ, Caldas C. PMC42, a breast progenitor cancer cell line, has normal-like mRNA and miRNA transcriptomes. Breast Cancer Research 2008; 10:R54

Meyer KB, Maia A-T, O'Reilly M, Teschendorff AE, Chin S-F, Caldas C, Ponder BAJ. Allele-specific up-regulation of FGFR2 increases susceptibility to breast cancer. PLoS Biology 2008; 6:e108

Reyal F, Van Vliet MH, Armstrong NJ, Horlings HM, de Visser KE, Kok M, Teschendorff AE, Mook S, Van't Veer L, Caldas C, Salmon RJ, Van de Vijver MJ, Wessels LF. A comprehensive analysis of prognostic signatures reveals the high predictive capacity of proliferation, immune response and RNA splicing modules in breast cancer. Breast Cancer Research 2008; 10:R93

Teschendorff AE, Caldas C. A robust classifier of high predictive value to identify good prognosis patients in ER negative breast cancer. Breast Cancer Research 2008; 10:R73

Veerakumarasivam A, Scott HE, Chin S-F, Warren A, Wallard MJ, Grimmer D, Ichimura K, Caldas C, Collins VP, Neal DE, Kelly JD. High-resolution array-based comparative genomic hybridization of bladder cancers identifies mouse double minute 4 (MDM4) as an amplification target exclusive of MDM2 and TP53. Clinical Cancer Research 2008; 4:2527-34

2007

Ahmed AA, Mills AD, Ibrahim AEK, Temple J, Blenkiron C, Vias M, Massie CE, Iyer NG, McGeoch A, Crawford R, Nicke B, Downward J, Swanton C, Bell SD, Earl HM, Laskey RA, Caldas C, Brenton JD. The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell 2007; 12(6):514-527

Blenkiron C, Goldstein LD, Thorne NP, Spiteri I, Chin SF, Dunning MJ, Barbosa-Morais NL, Teschendorff AE, Green AR, Ellis IO, Tavaré S, Caldas C, Miska EA. MicroRNA expression profiling of human breast cancer identifies new markers of tumor subtype. Genome Biol 2007; 8(10):Article R214

Carneiro F, Moutinho C, Pera G, Caldas C, Fenger C, Offerhaus J, Save V, Stenling R, Nesi G, Mahlke U, Blaker H, Torrado J, Roukos DH, Sabourin JC, Boeing H, Palli D, Bueno-De-Mesquita HB, Overvad K, Bingham S, Clavel-Chapelon F, Lund E, Trichopoulou A, Manjer J, Riboli E, Gonzalez CA Pathology findings and validation of gastric and esophageal cancer cases in a European cohort (EPIC/EUR-GAST). Scand J Gastroenterol 2007; 42(5):618-627

Chin SF, Teschendorff AE, Marioni JC, Wang Y, Barbosa-Morais NL, Thorne NP, Costa JL, Pinder SE, De Wiel MAV, Green AR, Ellis IO, Porter PL, Tavaré S, Brenton JD, Ylstra B, Caldas C. High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer. Genome Biol 2007; 8(10):Article R215

Chin SF, Wang Y, Thorne NP, Teschendorff AE, Pinder SE, Vias M, Naderi A, Roberts I, Barbosa-Morais NL, Garcia MJ, Iyer NG, Kranjac T, Robertson JFR, Aparicio S, Tavaré S, Ellis I, Brenton JD, Caldas C. Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers. Oncogene 2007; 26(13):1959-1970

Flinterman MB, Mymryk JS, Klanrit P, Yousef AF, Lowe SW, Caldas C, Gaken J, Farzaneh F, Tavassoli M. p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing. Oncogene 2007; 26(48):6863-6874

Foo RSY, Nam YJ, Ostreicher MJ, Metzl MD, Whelan RS, Peng CF, Ashton AW, Fu W, Mani K, Chin SF, Provenzano E, Ellis I, Figg N, Pinder S, Bennett MR, Caldas C, Kitsis RN. Regulation of p53 tetramerization and nuclear export by ARC. Proc Natl Acad Sci U S A 2007; 104(52):20826-20831

Iyer NG, Xian J, Chin SF, Bannister AJ, Daigo Y, Aparicio S, Kouzarides T, Caldas C. p300 is required for orderly G1/S transition in human cancer cells. Oncogene 2007; 26(1):21-29

Jong K, Marchiori E, van der Vaart A, Chin SF, Carvalho B, Tijssen M, Eijk PP, van den IJssel P, Grabsch H, Quirke P, Oudejans JJ, Meijer GA, Caldas C, Ylstra B. Cross-platform array comparative genomic hybridization meta-analysis separates hematopoietic and mesenchymal from epithelial tumors. Oncogene 2007; 26(10):1499-1506

Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setien F, Casado S, Suarez-Gauthier A, Sanchez-Cespedes M, Gitt A, Spiteri I, Das PP, Caldas C, Miska E, Esteller M. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res 2007; 67(4):1424-1429

Melchor L, Garcia MJ, Honrado E, Pole JCM, Alvarez S, Edwards PAW, CaldaS C, Brenton JD, Benitez J. Genomic analysis of the 8p11-12 amplicon in familial breast cancer. Int J Cancer 2007; 120(3):714-717

Miremadi A, Oestergaard MZ, Pharoah PDP, Caldas C. Cancer genetics of epigenetic genes. Hum Mol Genet 2007; 16(Spec Iss 1):R28-R49

Naderi A, Teschendorff AE, Barbosa-Morais NI, Pinder SE, Green AR, Powe DG, Robertson JFR, Aparicio S, Ellis IO, Brenton JD, Caldas C. A gene-expression signature to predict survival in breast cancer across independent data sets. Oncogene 2007; 26(10):1507-1516

Naderi A, Teschendorff AE, Beigel J, Cariati M, Ellis IO, Brenton JD, Caldas C. BEX2 is overexpressed in a subset of primary breast cancers and mediates nerve growth factor/nuclear factor-kappa B inhibition of apoptosis in breast cancer cell lines. Cancer Res 2007; 67(14):6725-6736

Paterson AL, Pole JCM, Blood KA, Garcia MJ, Cooke SL, Teschendorff AE, Wang YZ, Chin SF, Ylstra B, Caldas C, Edwards PAW. Co-amplification of 8p 12 and 1 1q 13 in breast cancers is not the result of a single genomic event. Genes Chromosomes Cancer 2007; 46(5):427-439

Teschendorff AE, Journee M, Absil PA, Sepulchre R, Caldas C. Elucidating the altered transcriptional programs in breast cancer using independent component analysis. PLoS Comput Biol 2007; 3(8):1539-1554

Teschendorff AE, Miremadi A, Pinder SE, Ellis IO, Caldas C. An immune response gene expression module identifies a good prognosis subtype in estrogen receptor negative breast cancer. Genome Biol 2007; 8(8):Article R157

Udler M, Maia AT, Cebrian A, Brown C, Greenberg D, Shah M, Caldas C, Dunning A, Easton D, Ponder B, Pharoah P. Common germline genetic variation in antioxidant defense genes and survival after diagnosis of breast cancer. J Clin Oncol 2007; 25(21):3015-3023

2006

Barber M, Fitzgerald RC, Caldas C. Familial gastric cancer - aetiology and pathogenesis. Best Pract Res Clin Gastroenterol 2006; 20(4):721-734

Boyer J, Allen WL, McLean EG, Wilson PM, McCulla A, Moore S, Longley DB, Caldas C, Johnston PG. Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res 2006; 66(5):2765-2777

Brachner A, Sasgary S, Pirker C, Rodgarkia C, Mikula M, Mikulits W, Bergmeister H, Setinek U, Wieser M, Chin SF, Caldas C, Micksche M, Cerni C, Berger W. Telomerase- and alternative telomere lengthening-independent telomere stabilization in a metastasis-derived human non-small cell lung cancer cell line: Effect of ectopic hTERT. Cancer Res 2006; 66(7):3584-3592

Bundy JG, Iyer NG, Gentile MS, Hu DE, Kettunen M, Maia AT, Thorne NP, Brenton JD, Caldas C, Brindle KM. Metabolic consequences of p300 gene deletion in human colon cancer cells. Cancer Res 2006; 66(15):7606-7614

Callagy GM, Pharoah PD, Pinder SE, Hsu FD, Nielsen TO, Ragaz J, Ellis IO, Huntsman D, Caldas C. Bcl-2 is a prognostic marker in breast cancer independently of the Nottingham Prognostic Index. Clin Cancer Res 2006; 12(8):2468-2475

Camps J, Salaverria I, Garcia MJ, Prat E, Bea S, Pole JC, Hernandez L, Del Rey J, Cigudosa JC, Bernues M, Caldas C, Colomer D, Miro R, Campo E. Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines. Leuk Res 2006; 30(8):923-934

Fitzgerald RC, Caldas C. Familial gastric cancer - clinical management. Best Pract Res Clin Gastroenterol 2006; 20(4):735-743

Griffin JL, Blenkiron C, Valonen PK, Caldas C, Kauppinen RA. High-resolution magic angle spinning H-1 NMR spectroscopy and reverse transcription-PCR analysis of apoptosis in a rat glioma. Anal Chem 2006; 78(5):1546-1552

Krubasik D, Iyer NG, English WR, Ahmed AA, Vias M, Roskelley C, Brenton JD, Caldas C, Murphy G. Absence of p300 induces cellular phenotypic changes characteristic of epithelial to mesenchyme transition. Br J Cancer 2006; 94(9):1326-1332

Kunapuli P, Kasyapaa CS, Chin SF, Caldas C, Cowell JK. ZNF198, a zinc finger protein rearranged in myeloproliferative disease, localizes to the PML nuclear bodies and interacts with SUMO-1 and PML. Exp Cell Res 2006; 312(19):3739-3751

Onwuegbusi BA, Aitchison A, Chin SF, Kranjac T, Mills I, Huang Y, Lao-Sirieix P, Caldas C, Fitzgerald RC. Impaired transforming growth factor beta signalling in Barrett's carcinogenesis due to frequent SMAD4 inactivation. Gut 2006; 55(6):764-774

Ozdag H, Teschendorff AE, Ahmed AA, Hyland SJ, Blenkiron C, Bobrow L, Veerakumarasivam A, Burtt G, Subkhankulova T, Arends MJ, Collins VP, Bowtell D, Kouzarides T, Brenton JD, Caldas C. Differential expression of selected histone modifier genes in human solid cancers. BMC Genomics 2006; 7:Article 90

Pole JCM, Courtay-Cahen C, Garcia MJ, Blood KA, Cooke SL, Alsop AE, Tse DML, Caldas C, Edwards PAW. High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation. Oncogene 2006; 25(41):5693-5706

Rodriguez-Sanjuan JC, Fontalba A, Mayorga M, Bordin MC, Hyland SJ, Trugeda S, Garcia RA, Gomez-Fleitas M, Fernandez F, Caldas C, Fernandez-Luna JL. A novel mutation in the E-cadherin gene in the first family with hereditary diffuse gastric cancer reported in Spain. Eur J Surg Oncol 2006; 32(10):1110-1113

Teschendorff AE, Naderi A, Barbosa-Morais NL, Caldas C. PACK: Profile Analysis using Clustering and Kurtosis to find molecular classifiers in cancer. Bioinformatics 2006; 22(18):2269-2275

Teschendorff AE, Naderi A, Barbosa-Morais NL, Pinder SE, Ellis IO, Aparicio S, Brenton JD, Caldas C. A consensus prognostic gene expression classifier for ER positive breast cancer. Genome Biol 2006; 7(10):Article R101

2005

Callagy G, Pharoah P, Chin SF, Sangan T, Daigo Y, Jackson L, Caldas C. Identification and validation of prognostic markers in breast cancer with the complementary use of array-CGH and tissue microarrays. J Pathol 2005; 205(3):388-396

Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Perez-Rosado A, Calvo E, Lopez JA, Cano A, Calasanz MJ, Colomer D, Piris MA, Ahn N, Imhof A, Caldas C, Jenuwein T, Esteller M. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 2005; 37(4):391-400

Garcia MJ, Pole JCM, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PAW, Caldas C. A 1Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. Oncogene 2005; 24(33):5235-5245

Gorringe KL, Chin SF, Pharoah P, Staines JM, Oliveira C, Edwards PAW, Caldas C. Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer. Carcinogenesis 2005; 26(5):923-930

Grigorova M, Lyman RC, Caldas C, Edwards PAW. Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed with spectral karyotyping. Cancer Genet Cytogenet 2005; 162(1):1-9

Naderi A, Ahmed AA, Wang YZ, Brenton JD, Caldas C. Optimal amounts of fluorescent dye improve expression microarray results in tumor specimens. Mol Biotechnol 2005; 30(2):151-154

Teschendorff AE, Wang YZ, Barbosa-Morais NL, Brenton JD, Caldas C. A variational Bayesian mixture modelling framework for cluster analysis of gene-expression data. Bioinformatics 2005; 21(13):3025-3033

van den IJssel P, Tijssen M, Chin SF, Eijk P, Carvalho B, Hopmans E, Holstege H, Bangarusamy DK, Jonkers J, Meijer GA, Caldas C, Ylstra B. Human and mouse oligonucleotide-based array CGH. Nucleic Acids Res 2005; 33(22):Article e192

2004

Ahmed AA, Vias M, Iyer NG, Caldas C, Brenton JD. Microarray segmentation methods significantly influence data precision. Nucleic Acids Res 2004; 32(5):Article e5

Brooks-Wilson AR, Kaurah P, Suriano G, Leach S, Senz J, Grehan N, Butterfield YSN, Jeyes J, Schinas J, Bacani J, Kelsey M, Ferreira P, MacGillivray B, Macleod P, Micek M, Ford J, Foulkes W, Australie K, Greenberg C, LaPointe M, Gilpin C, Nikkel S, Gilchrist D, Hughes R, Jackson CE, Monaghan KG, Oliveira MJ, Seruca R, Gallinger S, Caldas C, Huntsman D. Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria. J Med Genet 2004; 41(7):508-517

Carneiro F, Huntsman DG, Smyrk TC, Owen DA, Seruca R, Pharoah P, Caldas C, Sobrinho-Simoes M. Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening. J Pathol 2004; 203(2):681-687

Daigo Y, Takayama D, Ponder BA, Caldas C, Ward SM, Sanders KM, Fujino MA. Novel human, mouse and xenopus genes encoding a member of the RAS superfamily of low-molecular-weight GTP-binding proteins and its downregulation in W/W-v mouse jejunum. J Gastroenterol Hepatol 2004; 19(2):211-217

Grigorova M, Staines JM, Ozdag H, Caldas C, Edwards PAW. Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. Cytogenet Genome Res 2004; 104(1-4):333-340

Huang HE, Chin SF, Ginestier C, Bardou VJ, Adelaide J, Iyer NG, Garcia MJ, Pole JC, Callagy GM, Hewitt SM, Gullick WJ, Jacquemier J, Caldas C, Chaffanet M, Birnbaum D, Edwards PAW. A recurrent chromosome breakpoint in breast cancer at the NRG1/Neuregulin 1/Heregulin gene. Cancer Res 2004; 64(19):6840-6844

Iyer NG, Chin SF, Ozdag H, Daigo Y, Hu DE, Cariati M, Brindle K, Aparicio S, Caldas C. P300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. Proc Natl Acad Sci U S A 2004; 101(19):7386-7391

Naderi A, Ahmed AA, Barbosa-Morais NL, Aparicio S, Brenton JD, Caldas C. Expression microarray reproducibility is improved by optimising purification steps in RNA amplification and labelling. BMC Genomics 2004; 5:Article 9

2003

Callagy G, Cattaneo E, Daigo Y, Happerfield L, Bobrow LG, Pharoah PDP, Caldas C. Molecular classification of breast carcinomas using tissue microarrays. Diagn Mol Pathol 2003; 12(1):27-34

Chin SF, Daigo Y, Huang HE, Iyer NG, Callagy G, Kranjac T, Gonzalez M, Sangan T, Earl H, Caldas C. A simple and reliable pretreatment protocol facilitates fluorescent in situ hybridisation on tissue microarrays of paraffin wax embedded tumour samples. J Clin Pathol Mol Pathol 2003; 56(5):275-279

Daigo Y, Takayama I, Ponder BAJ, Caldas C, Ward SM, Sanders KM, Fujino MA. Differential gene expression profile in the small intestines of mice lacking pacemaker interstitial cells of Cajal. BMC Gastroenterol 2003; 3:Article 17

Hughes-Davies L, Huntsman D, Ruas M, Fuks F, Bye J, Chin SF, Milner J, Brown LA, Hsu F, Gilks B, Nielsen T, Schulzer M, Chia S, Ragaz J, Cahn A, Linger L, Ozdag H, Cattaneo E, Jordanova ES, Schuuring E, Yu DS, Venkitaraman A, Ponder B, Doherty A, Aparicio S, Bentley D, Theillet C, Ponting CP, Caldas C, Kouzarides T. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Cell 2003; 115(5):523-535

Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, Alves CC, Campos ML, Van Doorn LJ, Caldas C, Seruca R, Carneiro F, Sobrinho-Simoes M. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 2003; 125(2):364-371

Suriano G, Oliveira C, Ferreira P, Machado JC, Bordin MC, De Wever O, Bruyneel EA, Moguilevsky N, Grehan N, Porter TR, Richards FM, Hruban RH, Roviello F, Huntsman D, Mareel M, Carneiro F, Caldas C, Seruca R. Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands. Hum Mol Genet 2003; 12(5):575-582

2002

Figueiredo C, Machodo JC, Pharoah P, Seruca R, Sousa S, Carvalho R, Capelinha AF, Quint W, Caldas C, van Doorn LJ, Carneiro F, Sobrinho-Simoes M. Helicobacter pylori and interleukin 1 genotyping: An opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst 2002; 94(22):1680-1687

Oliveira C, Bordin MC, Grehan N, Huntsman D, Suriano G, Machado JC, Kiviluoto T, Aaltonen L, Jackson CE, Seruca R, Caldas C. Screening E-cadherin in gastric cancer families reveals germline mutations only in hereditary diffuse gastric cancer kindred. Hum Mutat 2002; 19(5):510-517

Ozdag H, Batley SJ, Forsti A, Iyer NG, Daigo Y, Boutell J, Arends MJ, Ponder BAJ, Kouzarides T, Caldas C. Mutation analysis of CBP and PCAF reveals rare inactivating mutations in cancer cell lines but not In primary tumours. Br J Cancer 2002; 87(10):1162-1165

Pharoah PDP, Oliveira C, Machado JC, Keller G, Vogelsang H, Laux H, Becker KF, Hahn H, Paproski SM, Brown LA, Caldas C, Huntsman D. CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer. Int J Cancer 2002; 101(2):196-197

Other Publications

Costa JL, Meijer G, Ylstra B, Caldas C. Array comparative genomic hybridization copy number profiling: A new tool for translational research in solid malignancies. Seminars in Radiation Oncology 2008; 18:98-104

Sassen S, Miska EA, Caldas C. MicroRNA: implications for cancer. Virchows Archiv 2008; 452:1-10

Stingl J, Caldas C. Opinion - Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis. Nat Rev Cancer 2007; 7(10):791-799

Abraham J, Earl HM, Pharoah PD, Caldas C. Pharmacogenetics of cancer chemotherapy. Biochim Biophys Acta [Rev Cancer] 2006; 1766(2):168-183

Brenton JD, Ahmed AA, Caldas C. Molecular forecasting of breast cancer: Time to move forward with clinical testing - In reply. J Clin Oncol 2006; 24(4):722-723

Caldas C, Edwards PAW. A quantum leap in our knowledge of breast cancer mutations. Breast Cancer Res 2006; 8(6):Article 304

Brenton JD, Carey LA, Ahmed AA, Caldas C. Molecular classification and molecular forecasting of breast cancer: Ready for clinical application? J Clin Oncol 2005; 23(29):7350-7360

Caldas C, Brenton JD. Sizing up miRNAs as cancer genes. Nat Med 2005; 11(7):712-714

Capella G, Caldas C. MTAP homozygous deletion - An Achilles heel of human cancers ready for clinical use? Cancer Biol Ther 2005; 4(3):347-347

Santos-Rosa H, Caldas C. Chromatin modifier enzymes, the histone code and cancer. Eur J Cancer 2005; 41(16):2381-2402

Fitzgerald RC, Caldas C. Clinical implications of E-cadherin associated hereditary diffuse gastric cancer. Gut 2004; 53(6):775-778

Iyer NG, Ozdag H, Caldas C. p300/CBP and cancer. Oncogene 2004; 23(24):4225-4231

Brenton JD, Caldas C. Predictive cancer genomics - what do we need? Lancet 2003; 362(9381):340-341

Oliveira C, Seruca R, Caldas C. Genetic screening for hereditary diffuse gastric cancer. Expert Rev Mol Diagn 2003; 3(2):201-215

Caldas C, Aparicio SAJ. Cancer - The molecular outlook. Nature 2002; 415(6871):484-485

Fitzgerald RC, Caldas C. E-cadherin mutations and hereditary gastric cancer: Prevention by resection? Dig Dis 2002; 20(1):23-31

Pharoah P, Caldas C, Huntsman D, Guilford P. E-cadherin germline mutations and risk of gastric cancer - Reply. Gastroenterology 2002; 123(4):1406-1407