The Markowetz lab develops algorithms and statistics to better understand biological and clinical datasets and to leverage complex and heterogeneous data sources for biomedical research.
Understanding the cell by breaking it
One of our key areas of interest is developing strategies to reconstruct cellular pathways and their condition-specific re-wiring from gene perturbation assays.
Cancer genomics and genetics
With our partners at the CRI we develop systems approaches to dissect the genomic basis of breast cancer and identify disrupted signaling pathways in tumors with the goal of discovering novel biomarkers and diagnosing disease sub-types by their molecular signatures.
Stem cell biology
With international collaboration partners we work on defining regulatory networks of key pluripotency modulators, compare them between different stem cell types, and characterize their re-wiring during differentation.
