Selected Publications
2009
Thirkettle HJ, Mills IG, Whitaker HC, Neal DE. Nuclear LYRIC/AEG-1 interacts with PLZF and relieves PLZF-mediated repression. Oncogene 2009 Aug 3. [Epub ahead of print] PubMed.
Borlido J, Zecchini V, Mills IG. Nuclear trafficking and functions of endocytic proteins implicated in oncogenesis. Traffic 2009;10(9): 1209-1220. Epub 2009 May 12. PubMed.
Thirkettle HJ, Girling J, Warren AY, Mills IG, Sahadevan K, Leung H, Hamdy F, Whitaker HC, Neal DE. LYRIC/AEG-1 is targeted to different subcellular compartments by ubiquitinylation and intrinsic nuclear localization signals. Clin Cancer Res 2009; 15(9): 3003-3013. Epub 2009 Apr 21. PubMed.
Zecchini V, Mills IG. Putting chromatin immunoprecipitation into context. J Cell Biochem 2009 Feb 9; Epub ahead of print. PubMed.
Abedin SA, Thorne JL, Battaglia S, Maguire O, Hornung L, Doherty AP, Mills IG, Campbell MJ. Elevated NCOR1 disrupts a network of dietary-sensing nuclear receptors in bladder cancer cells. Carcinogenesis 2009 Jan 6; Epub ahead of print. PubMed.
Massie CE, Mills IG. Chromatin Immunoprecipitation (ChIP) Methodology and Readouts. Methods Mol Biol 2009; 505: 123-137. PubMed.
2008
Veerakumarasivam A, Goldstein LD, Saeb-Parsy K, Scott HE, Warren A, Thorne NP, Mills IG, Venkitaraman A, Neal DE, Kelly JD. AURKA overexpression accompanies dysregulation of DNA-damage response genes in invasive urothelial cell carcinoma. Cell Cycle 2008; 7(22): 3525-3533. PubMed
Vias M, Ramos-Montoya A, Mills IG. Terminal and progenitor lineage-survival oncogenes as cancer markers. Trends Mol Med 2008 Oct 15; Epub ahead of print. PubMed.
Borlido J, Veltri G, Jackson AP, Mills IG. Clathrin is spindle-associated but not essential for mitosis. PLoS ONE 2008; 3(9):e3115. [PMID: 18769625] Open access to full text.
Saeb-Parsy K, Veerakumarasivam A, Wallard MJ, Thorne N, Kawano Y, Murphy G, Neal DE, Mills IG, Kelly JD. MT1-MMP regulates urothelial cell invasion via transcriptional regulation of Dickkopf-3. Br J Cancer 2008 Jul 29; [Epub ahead of print]
Attard G, Clark J, Ambroisine L, Mills IG, Fisher G, Flohr P, Reid A, Edwards S, Kovacs G, Berney D, Foster C, Massie CE, Fletcher A, De Bono JS, Scardino P, Cuzick J, Cooper CS. Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer. Br J Cancer 2008; [Epub ahead of print: PMID: 18594527].
Whitaker HC, Girling J, Warren AY, Leung H, Mills IG, Neal DE. Alterations in beta-catenin expression and localization in prostate cancer. Prostate 2008; [Epub ahead of print: PMID: 18459111]
Vias M, Massie CE, East P, Scott H, Warren A, Zhou Z, Nikitin AY, Neal DE, Mills IG. Pro-neural transcription factors as cancer markers. BMC Med Genomics 2008; 1(1):17.
Massie CE, Mills IG. ChIPping away at gene regulation. EMBO Rep 2008; 9(4): 337-343.
Cutress ML, Whitaker HC, Mills IG, Stewart M, Neal DE. Structural basis for the nuclear import of the human androgen receptor. J Cell Sci 2008; 121(Pt 7): 957-968.
Olesen LE, Ford MGJ, Schmid EM, Vallis Y, Madan Babu M, Li P, Mills IG, McMahon HT, Praefcke GJK. Solitary and repetitive binding motifs for the AP2 complex α-appendage in amphiphysin and other accessory proteins. J Biol Chem 2008; 283(8): 5099-5109.
2007
Aitchison AA, Veerakumarasivam A, Vias M, Kumar R, Hamdy FC, Neal DE, Mills IG. Promoter methylation correlates with reduced Smad4 expression in advanced prostate cancer. Prostate 2007; 68(6): 661-674.
Mills IG. The interplay between clathrin-coated vesicles and cell signalling. Seminars in Cell and Developmental Biology (invited review; editor: Corinne Smith) 2007; 18(4): 459-470.
Massie CE, Adryan B, Barbosa-Morais N, Lynch A, Neal DE, Mills IG. ChIP-on-chip identifies novel Androgen Receptor genomic binding sites and reveals an interaction with ETS1. EMBO Reports 2007; 8(9): 871-878; epub 2007 Aug 17.
Wicker N, Carles A, Mills IG, Wolf M, Veerakumarasivam A, Edgren H, Boileau F, Wasylyk B, Schalken JA, Neal DE, Kalloniemi O, Poch O. A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH. BMC Genomics 2007; 8: 84.
Girling JS, Whitaker HC, Mills IG, Neal DE. Pathogenesis of prostate cancer and hormone refractory prostate cancer. Indian Journal of Urology (invited review) 2007; in press.
Vias M, Burtt G, Culig Z, Veerakumarasivam A, Neal DE, Mills IG. A role for neurotensin in bicalutamide resistant prostate cancer cells. Prostate 2007; 67(2): 190-202
2006
Schmid EM, Ford MGJ, Burtey A, Praefcke GJK, Peak-Chew S-Y, Mills IG, Benmerah A, McMahon HT. Role of AP2β-appendage hub in recruiting partners for clathrin-coated vesicle assembly. PLoS Biology 2006; 4(9): e262.
Massie CE, Mills IG. The developing role of receptors and adaptors. Nature Reviews in Cancer 2006; 6(5): 403-409.
Wallard MJ, Pennington CJ, Veerakumarasivam A, Burtt G, Mills IG, Warren A, Leung HY, Murphy G, Edwards DR, Neal DE and Kelly JD. Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma. Br J Cancer 2006; 94(4): 569-577.
Onwuegbusi BA, Aitchison A, Chin SF, Kranjac T, Mills I, Huang Y, Lao-Sirieix P, Caldas C, Fitzgerald RC. Impaired TGFβ signalling in Barrett's carcinogenesis due to frequent SMAD4 inactivation. Gut 2006; 55(6): 764-774.
2005
Mills IG, Gaughan L, Robson C, Ross T, McCracken S, Kelly JD, Neal DE. Huntingtin Interacting Protein 1 (HIP1) modulates the transcriptional activity of nuclear hormone receptors. Journal of Cell Biology 2005; 170: 191-200.
2004
Praefcke GJK, Ford MGJ, Schmid EM, Olesen LE, Gallop JL, Peak-Chew S-Y, Vallis Y, Babu MM, Mills IG., McMahon HT. Evolving nature of the AP2 α-appendage hub during clathrin-coated vesicle. EMBO Journal 2004; 23(22): 4371-4383.
McMahon HT, Mills IG. COP and clathrin-coated vesicle budding: different pathways, common approaches. Current Opinion in Cell Biology 2004; 16(4): 379-391.
Saint-Pol A, Yelamos B, Amessou M, Mills IG, Dugast M, Tenza D, Schu P, Antony C, McMahon HT, Lamaze C, Johannes L. EpsinR - a clathrin adaptor required for retrograde sorting on early endosomal membranes. Developmental Cell 2004; 6(4): 525-538.
Peter BJ, Kent HM, Mills IG, Vallis Y, Butler PJ, Evans PR and McMahon HT. BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure. Science 2004; 303(5657): 495-499.
2003
Mills IG, Praefcke GJK, Peter BJ, Vallis Y, Gallop JL, Evans PR and McMahon HT. EpsinR: an AP1/clathrin interacting protein involved in vesicle trafficking. Journal of Cell Biology 2003; 160: 213-222.
2002
*Ford MGJ, *Mills IG, Peter BJ, Vallis Y, Praefcke GJK, Evans PR and McMahon HT. Curvature of clathrin-coated pits driven by epsin. Nature 2002; 419: 361-366. (*The authors contributed equally to this work).
2001
Mills IG, Urbe S and Clague MJ. Relationships between EEA1 binding partners and their role in endosome fusion. Journal of Cell Science 2001; 114: 1959-1965.
Marks B, Stowell MH, Vallis Y, Mills IG, Gibson A, Hopkins CR and McMahon HT. GTPase activity of dynamin and resulting conformation change are essential for endocytosis. Nature 2001; 410: 231-235.
2000
Urbe S, Mills IG, Stenmark H, Kitmaura N and Clague MJ. Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate. Molecular and Cellular Biology 2000; 20: 7685-7692.
1999
Clague MJ, Jones AT, Mills IG, Walker DG and Urbe S. Regulation of early-endosome dynamics by phosphatidylinositol 3-phosphate binding proteins. Biochemical Society Transactions 1999; 27: 662-666.
Mills IG, Jones AT and Clague MJ. Regulation of endosome fusion. Molecular Membrane Biology 1999; 16: 73-79.
1998
Mills IG, Jones AT and Clague MJ. Involvement of the endosomal autoantigen EEA1 in homotypic fusion of early endosomes. Current Biology 1998; 16: 881-884.
Jones AT, Mills IG, Scheidig AJ, Alexandrov K and Clague MJ. Inhibition of endosome fusion by wortmannin persists in the presence of activated Rab5. Molecular Biology of the Cell 1998; 9: 323-332.
1997
Stanley LA, Mills IG and Sim E. Localization of polymorphic N-acetyltransferase (NAT2) in tissues of inbred mice. Pharmacogenetics 1997; 7: 121-130.
