Gillian Murphy

Proteases and Tumour Micro-environment
Cancer Research UK Cambridge Research Institute
Li Ka Shing Centre
Robinson Way
Cambridge
CB2 0RE

Research Goals
Our research is currently focused on cell surface associated forms of the zinc-dependent proteinases, notably the membrane type matrix metalloproteinases (MT MMPs) and the disintegrin-type metalloproteinases (ADAMs), and the natural inhibitors that control them, the tissue inhibitors of metalloproteinases, TIMPs. We aim to elucidate how these metalloproteinases and inhibitors function and what their importance is as effectors of both physiological processes and pathologies, such as cancer. The development of novel reagents for disease therapy and diagnosis will emerge from the fundamental data accrued.

Qualifications and Personal History
1971 - PhD, University of Birmingham.
1972-1974 - NATO Fellow at MPI, Martinsried
1974-1997 - Postdoctoral work and ARC Fellowship, Joint Head of Department at Strangeways Research Laboratory, Cambridge
1997-2002 - Professor at University of East Anglia (UEA), Norwich
2002 to present - Professor at University of Cambridge

Joined the Cancer Research UK Cambridge Research Institute in January 2007.