Selected Publications
Murrell A, Rakyan VK and Beck S. From genome to epigenome. Hum Mol Gen 2005; 14 (suppl 1): R3-R10. PubMed
Murrell A, Heeson S and Reik W. Interaction between differentially methylated regions partitions the imprinted genes Igf2 and H19 into parent specific loops. Nat Gen 2004; 36: 889-893. PubMed
Murrell A, Heeson S, Cooper WN, Douglas E, Apostolidou S, Moore GE, Maher ER and Reik W. An association between variants in the IGF2 gene and Beckwith Wiedemann syndrome: an interaction between genotype and epigenotype. Hum Molr Gen 2004; 13: 247-255. PubMed
Lewis A and Murrell A. Genomic imprinting: CTCF protects the boundaries. Curr Biol 2004; 14: R284-R286. PubMed
Primary Research Publications
2008
Barber ME, Murrell A, Ito Y, Maia A-T, Hyland S, Oliveira C, Save V, Carneiro F, Paterson AL, Grehan N, Dwerryhouse S, Lao-Sirieix P, Caldas C, Fitzgerald RC. Mechanisms and sequelae of E-cadherin silencing in hereditary diffuse gastric cancer. The Journal of Pathology 2008; 216:295-306
Ito Y, Koessler T, Ibrahim AE, Rai S, Vowler SL, Abu-Amero S, Silva AL, Maia A-T, Huddleston JE, Uribe-Lewis S, Woodfine K, Jagodic M, Nativio R, Dunning A, Moore G, Klenova E, Bingham S, Pharoah PD, Brenton JD, Beck S, Sandhu MS, Murrell A. Somatically acquired hypomethylation of IGF2 in breast and colorectal cancer. Human Molecular Genetics 2008; 17:2633-43
Murrell A, Ito Y, Verde G, Huddleston J, Woodfine K, Silengo M C, Spreafico F, Perotti D, De Crescenzo A, Sparago A, Cerrato F, Riccio A. Distinct methylation changes at the IGF2-H19 locus in congenital growth disorders and cancer. PLoS ONE 2008; 3:E1849
Tomazou EM, Rakyan VK, Lefebvre G, Andrews R, Ellis P, Jackson DK, Langford C, Francis MD, Bäckdahl L, Miretti M, Coggill P, Ottaviani D, Sheer D, Murrell A, Beck S. Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis. BMC Medical Genomics. 2008; 1:19
2006
Kurukuti S, Tiwari VK, Tavoosidana G, Pugacheva E, Murrell A, Zhao ZH, Lobanenkov V, Reik W, Ohlsson R. CTCF binding at the H19 imprinting control region mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to Igf2. Proc Natl Acad Sci U S A 2006; 103(28):10684-10689
Lovett FA, Gonzalez I, Salih DAM, Cobb LJ, Tripathi G, Cosgrove RA, Murrell A, Kilshaw PJ, Pell JM. Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiation. J Cell Sci 2006; 119(23):4828-4840
Monk D, Sanches R, Arnaud P, Apostolidou S, Hills FA, Abu-Amero S, Murrell A, Friess H, Reik W, Stanier P, Constancia M, Moore GE. Imprinting of IGF2 P0 transcript and novel alternatively spliced INS-IGF2 isoforms show differences between mouse and human. Hum Mol Genet 2006; 15(8):1259-1269
Other Publications
Murrell A. Genomic imprinting and cancer: From primordial germ cells to somatic cells. ScientificWorldJournal 2006; 6:1888-1910
Murrell A, Rakyan VK, Beck S. From genome to epigenome. Hum Mol Genet 2005; 14(Spec Iss 1):R3-R10
