1. To identify the genes that underlie susceptibility to the common cancers.
2. To elucidate the spectrum of rare and common genetic variation that underlies susceptibility.
3. To develop phenotypic assays that are practicable on an epidemiological scale to assist in the search for these genes.
4. To use knowledge of susceptibility genes to elucidate new mechanisms of carcinogenesis.
5. To explore the use of genetic information to define groups at different risk in the population, and so to design programmes of screening and prevention.Research is conducted in close collaboration with Doug Easton and Paul Pharoah at the Strangeways Research Laboratory.
