Selected Publications

Lain S., Midgley C., Sparks A., Lane E.B., and Lane D.P. (1999) An Inhibitor of Nuclear Export Activates the p53 Response and Induces the Localization of HDM2 and p53 to U1A-Positive Nuclear Bodies Associated with the PODs. Experimental Cell Research 248, 457-472.

Rodriguez M.S., Desterro J.M., Lain S., Midgley C.A., Lane D.P., Hay R.T., (1999) SUMO-1 modification activates the transcriptional response of p53. EMBO Journal 15;18(22):6455-61.

Midgley C.A., Desterro J.M.P., Saville M.K., Howard S., Sparks A., Hay R.T., Lane D.P., (2000) An N-terminal p14 ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo. Oncogene 19, 2312-2323

Hietanen S., Lain S., Krausz E., Blattner C., Lane D.P. (2000) Activation of p53 in cervical carcinoma cells by small molecules. PNAS Vol. 97 8501-8506

Rodriguez M.S., Desterro J.M.P., Lain S., Lane D.P., Hay R.T., (2000) Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation. Molecular & Cellular Biology, Vol 20, 8458-8467