Selected Publications
Wolf, C.R. Metabolic factors in cancer susceptibility. In: Franks, L.M. (ed): Cancer Surveys 9, 437-474 (1990).
Gough, A.C., Miles, J.S., Spurr, N.K., Moss, J.E., Gaedigk, A., Eichelbaum, M. and Wolf, C.R. Identification of the primary gene defect at the cytochrome P450 CYP2D locus. Nature 347, 773-776 (1990).
Forrester, L.M., Neal, G.E., Judah, D.J., Glancey, M.J. and Wolf, C.R. Evidence for involvement of multiple forms of cytochrome P-450 in aflatoxin B1 metabolism in human liver. Proc. Natl. Acad. Sci, USA 87, 8306-8310 (1990).
Moffat, G.J., McLaren, A.W. and Wolf, C.R. Involvement of Jun and Fos proteins in regulating transcriptional activation of the human pi class glutathione S-transferase gene in multidrug-resistant MCF7 breast cancer cells. J. Biol. Chem. 269,16397-16402 (1994).
Henderson, C.J., Smith, A.G., Ure, J., Brown, K., Bacon, E.J. and Wolf, C.R. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc. Natl. Acad. Sci. USA 95, 5275-5280 (1998).
Yin, Z., Ivanov, V., Adler, V., Tew, K., Henderson, C.J., Wolf, C.R., Ichijo, H. and Ronai, Z. GSTp-elicited protection against UV/H202-induced cell death is mediated by coordinated regulation of p38, ERK, JNK and NFkB. Proc. Natl. Acad. Sci. USA (2000).
Wolf, C.R. Chemoprevention: Increased potential to bear fruit. Commentary. Proc. Natl. Acad. Sci. USA 98, 2941-2943 (2001).
Smith, G., Carey, F.A., Beattie, J., Wilkie, M.J.V., Lightfoot, T.J., Coxhead, J., Garner, R.C., Steele, R.J.C., Wolf, C.R. Mutations in APC, Kirsten-ras and p53 - alternative genetic pathways to colorectal cancer. Proc. Natl. Acad. Sci. USA 99, 9433-9438 (2002).
Henderson, C.J., Otto, D.M.E., Carrie, D., Magnuson, M.A., McLaren, A.W., Rosewell, I. and Wolf, C.R. Inactivation of the hepatic cytochrome P450 system by conditional deletion of hepatic cytochrome P450 reductase. J. Biol. Chem. 278, 13480-13486 (2003).
Otto, D.M.E., Henderson, C.J., Carrie, D., Davey, M., Adams, R.H., Tickle, C. and Wolf, C.R. Identification of novel roles of the cytochrome P450 system in early embryogenesis; effects on vasculogenesis and retinoic acid homeostasis. Mol. Cell. Biol. (2003).
Primary Research Papers
Baron JM, Goh LB, Yao DG, Wolf CR, Friedberg T. Modulation of P450 CYP3A4-dependent metabolism by p-glycoprotein: implications for P450 phenotyping. Journal of Pharmacology and Experimental Therapeutics 2001; 296: 351-358.
Ding S, Yao D, Deeni YY, Burchell B, Wolf CR, Friedberg T. Human NADPH-P450 oxidoreductase modulates the level of cytochrome P450 CYP2D6 holoprotein via haem oxygenase-dependent and -independent pathways. Biochemical Journal 2001; 356: 613-619.
Dohr O, Paine MJI, Friedberg T, Roberts GCK, Wolf CR. Engineering of a functional human NADH-dependent cytochrome P450 system. Proceedings of the National Academy of Sciences of the USA 2001; 98: 81-86.
Gutierrez A, Doehr O, Paine M, Wolf CR, Scrutton NS, Roberts GCK. Trp-676 facilitates nicotinamide coenzyme exchange in the reductive half-reaction of human cytochrome P450 reductase: properties of the soluble W676R and W676A mutant reductases. Biochemistry 2000; 39: 15990-15999.
Gutierrez A, Lian L-Y, Wolf CR, Scrutton NS, Roberts GCK. Stopped-flow kinetic studies of flavin reduction in human cytochrome P450 reductase and its component domains. Biochemistry 2001; 40: 1964-1975.
Henderson CJ, Wolf CR, Kitteringham N, Powell H, Otto D, Park BK. Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione S-transferase pi. Proceedings of the National Academy of Sciences of the USA 2000; 97: 12741-12745.
Kim H, Putt DA, Zangar RC, Wolf CR, Guengerich FP, Edwards RJ, Hollenberg PF, Novak RF. Differential induction of rat hepatic cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in response to pyridine treatment. Drug Metabolism and Disposition 2001; 29: 353-360.
Li DN, Seidel A, Pritchard MP, Wolf CR, Friedberg T. Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol. Pharmacogenetics 2000; 10: 343-353.
McMahon M, Chanas SA, Henderson CJ, Wolf CR, Yamamoto M, Hayes JD. The Nrf2 transcription factor regulates basal expression of class Alpha and class Mu glutathione S-transferases in the mouse, but not necessarily their induction by cancer chemopreventive agents Chemico-Biological Interactions 2001; 133: 291-294.
McMahon M, Itoh K, Yamamoto M, Chanas SA, Henderson CJ, McLellan LI, Wolf CR, Cavin C, Hayes JD. The cap 'n' collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Research 2001; 61: 3299-3307.
Rosario LA, O'Brien ML, Henderson CJ, Wolf CR, Tew KD. Cellular response to a glutathione S-transferase P1-1 activated prodrug. Molecular Pharmacology 2000; 58: 167-174.
Wolf CR. Prospects for pharmacogenetics. Commentry: International Journal of Pharmaceutical Medicine 2001; 15: 57-58.
Wolf CR. Chemoprevention: Increased potential to bear fruit. Proceedings of the National Academy of Sciences of the USA 2001; 98: 2941-2943.
Yao DG, Ding S, Burchell B, Wolf CR, Friedberg T. Detoxication of vinca alkaloids by human P450 CYP3A4-mediated metabolism: implications for the development of drug resistance. Journal of Pharmacology and Experimental Therapeutics 2000; 294: 387-395.
