Selected Publications

Groom LA, Sneddon AA, Alessi DR, Dowd S, and Keyse SM. Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual specificity phosphatase. EMBO J. 1996; 15: 3621-3632.

Dowd, S, Sneddon AA, and Keyse SM. Isolation of the human genes encoding the Pyst1 and Pyst2 phosphatases: characterisation of Pyst2 as a cytosolic dual-specificity MAP kinase phosphatase and its catalytic activation by both MAP and SAP kinases. Journal of Cell Science 1998; 111: 3389-3399.

Stewart AE, Dowd, S, Keyse SM and McDonald NQ. Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation. Nature Structural Biology 1999; 6: 174-181.

Keyse SM. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Current Opinion in Cell Biology 2000; 12: 186-192.

Slack DN, Seternes OM, Gabrielsen M, Keyse SM. Distinct binding determinants for ERK2/p38α and JNK MAP kinases mediate catalytic activation and substrate selectivity of MAP kinase phosphatase-1. Journal of Biological Chemistry 2001; 276: 16491-16500.