Selected Publications

Carragher NO, Westhoff MA, Fincham VJ, Schaller MD, Frame MC. A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. Curr Biol. 2003 Aug 19;13(16):1442-50.

McLean GW, Avizienyte E, Frame MC. Focal adhesion kinase as a potential target in oncology. Expert Opin Pharmacother. 2003 Feb;4(2):227-34.

Jones RJ, Avizienyte E, Wyke AW, Owens DW, Brunton VG, Frame MC. Elevated c-Src is linked to altered cell-matrix adhesion rather than proliferation in KM12C human colorectal cancer cells. Br J Cancer. 2002 Nov 4;87(10):1128-35.

Avizienyte E, Wyke AW, Jones RJ, McLean GW, Westhoff MA, Brunton VG, Frame MC. Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol. 2002 Aug;4(8):632-8.

Frame MC, Fincham VJ, Carragher NO, Wyke JA. v-Src's hold over actin and cell adhesions. Nat Rev Mol Cell Biol. 2002 Apr;3(4):233-45.

Fincham VJ, Unlu M, Brunton VG, Pitts JD, Wyke JA, Frame MC. Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins. J. Cell Biol. 1996;135:1551-1564.

Fincham VJ, Frame MC. The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility. EMBO J. 1998;17:81-92.

Fincham VJ, Brunton VG, Frame MC. The SH3 domain directs acto-myosin dependent targeting of v-src to focal adhesions via PI 3-kinase. Mol Cell Biol. 2000;20:6518-6536.

Timpson P, Jones GE, Frame MC, Brunton VG. Coordination of cell polarisation and migration by the Rho family GTPases requires Src tyrosine kinase activity. Current Biology. 2001;11:1836-1846.

Carragher NO, Westhoff MA, Riley D, Potter DA, FrameMC. v-Src-induced modulation of the calpain-calpastatin proteolytic system regulates both morphological transformation and cell cycle progression. Mol. Cell Biol. 2002;22:257-269.