Cancer can be considered a disease of communication at the molecular level. Cellular communication uses biochemical networks that receive and integrate extracellular cues into specific cellular responses.

Using mainly Ras-Raf-MEK-MAPK/ERK signalling as a paradigm, we try to understand how a communication pathway can convert numerous input signals into specific responses that control such diversified functions as cell growth, survival and differentiation. For this we employ methods from molecular cell biology, biochemistry, bioinformatics and proteomics to analyse multiprotein signalling complexes and understand their function in signalling networks. Our aim is to advance insight into the molecular mechanisms of cancer development.