Colorectal Cancer is the third most common cancer in the western world and the second most common cause of cancer mortality. Thus, the focus of the colorectal cancer and Wnt signalling group is to try to understand the early changes associated with intestinal neoplasia to identify both novel markers of disease and hopefully new targets for therapy. The key intestinal tumour suppressor is the Apc gene which is mutated in approximately 80% of sporadic cancer. Germline heterozygosity of Apc leads to Familial Adenomatous Polyposis, a disease that leads to the prolific and early onset of colorectal tumours in patients under the age of 30. Central to our work is the use of novel inducible models of intestinal tumourigenesis which allow us to study the functions of specific tumour suppressor genes.