Selected Publications

Hornigold N, Devlin J, Davies AM, Aveyard JS, Habuchi Y and Knowles MA. Mutation of the 9q34 gene TSC1 in bladder cancer. Oncogene 1999; 18: 2657-2663.

Nishiyama H, Hornigold N, Davies AM and Knowles MA. A sequence-ready 840- Kb PAC contig spanning the candidate tumour suppressor locus DBC1 on human chromosome 9q32-33. Genomics 1999; 59: 335-338.

Sibley K, Stern P and Knowles MA. Frequency of fibroblast growth factor receptor 3 mutations in sporadic tumours. Oncogene 2001; 20: 4416-4418.

Sibley K, Cuthbert-Heavens D and Knowles MA. Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma. Oncogene 2001; 20: 686-691.

Nishiyama H, Takahashi T, Kakehi Y, Habuchi T and Knowles MA. Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary bladder cancer. Genes Chr. Cancer 1999; 26: 171-175.

Williams, S.V., Sibley, K.D., Davies, A.M., Nishiyama, H., Hornigold, N., Coulter, J., Kennedy, W.J., Skilleter, A., Habuchi, T. and Knowles, M.A. Molecular Genetic Analysis of Chromosome 9 Candidate Tumor-Suppressor Loci in Bladder Cancer Cell Lines. Genes, Chromosomes & Cancer. 2002; 34: 86-.69.

Munro, N.P. and Knowles, M.A. Fibroblast growth factors and their receptors in transitional cell carcinoma. Journal of Urology 2003; 80: 904-908.

Chester, J.D., Kennedy, W., Hall, G.D., Selby, P.J. and Knowles, M.A.. Negative regulation of G1/S transition by the candidate bladder cancer: efficient gene delivery to normal and malignant human urothelial cells in vitro and ex vivo. Gene Therapy 2003; 10: 172-179.

Primary Research Papers

Cruickshank SM, Southgate J, Trejdosiewicz LK. Normal human liver organ culture. In Vitro Cellular and Developmental Biology-Animal 2001; 37: 231-233.

Devlin J, Knowles MA. PCR microsatellite analysis of LOH in ovarian tumours. In: Bartlett JMS (ed.) Ovarian Cancer: Methods and Protocols. Methods in Molecular Medicine, Vol 39. Totowa: Humana, 2000; 307-314.

Diggle CP, Pitt E, Harnden P, Trejdosiewicz LK, Southgate J. Role of p53 in the responses of human urothelial cells to genotoxic damage. International Journal of Cancer 2001; 93: 199-203.

Diggle CP, Pitt E, Roberts P, Trejdosiewicz LK, Southgate J. N-3 and n-6 polyunsaturated fatty acids induce cytostasis in human urothelial cells independent of p53 gene function. Journal of Lipid Research 2000; 41: 1509-1515.

Forsti A, Louhelainen J, Soderberg M, Wijkstrom H, Hemminki K. Loss of heterozygosity in tumour-adjacent normal tissue of breast and bladder cancer. European Journal of Cancer 2001; 37: 1372-1380.

Habuchi T, Takahashi T, Kakinuma H, Wang LZ, Tsuchiya N, Satoh S, Akao T, Sato K, Ogawa O, Knowles MA, Kato T. Hypermethylation at 9q32-33 tumour suppressor region is age-related in normal urothelium and an early and frequent alteration in bladder cancer. Oncogene 2001; 20: 531-537.

Knowles MA. The genetics of bladder cancer. In: Cowell JK (ed.) Molecular Genetics of Cancer, 2nd ed. Oxford: Bios, 2001; 435-460.

Knowles MA. What we could do now:molecular pathology of bladder cancer. Journal of Clinical Pathology-Molecular Pathology 2001; 43: 215-221.

Louhelainen J, Wijkstrom H, Hemminki K. Multiple regions with allelic loss at chromosome 3 in superficial multifocal bladder tumors. International Journal of Oncology 2001; 18: 203-210.

Nishiyama H, Gill JH, Pitt E, Kennedy W, Knowles MA. Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. Oncogene 2001; 20: 2956-2964.

Randerson-Moor JA, Harland M, Williams S, Cuthbert-Heavens D, Sheridan E, Aveyard J, Sibley K, Whitaker L, Knowles M, Newton Bishop J, Bishop DT. A germline deletion of p14 ARF but not CDKN2A in a melanoma-neural system tumour syndrome family. Human Molecular Genetics 2001; 10: 55-62.

Sibley K, Bell S, Knowles MA. Redefining a critical region of LOH on 4p16.3 in bladder cancer. Genes Chromosomes and Cancer 2000; 29: 378-379.

Sibley K, Cuthbert-Heavens D, Knowles MA. Loss of heterozygosity at 4p16.3 and mutation of FGFR3 in transitional cell carcinoma. Oncogene 2001; 20: 686-691.

Sillett HK, Cruickshank SM, Southgate J, Trejdosiewicz LK. Transforming growth factor-b promotes 'death by neglect' in post-activated human T cells. Immunology 2001; 102: 310-316.

Smith BA, Kennedy WJ, Harnden P, Selby PJ, Trejdosiewicz LK, Southgate J. Identification of genes involved in human urothelial cell-matrix interactions: implications for the progression pathways of malignant urothelium. Cancer Research 2001; 61: 1678-1685.

Wada T, Louhelainen J, Hemminki K, Adofsson J, Wijkstrom H, Norming U, Borgstrom E, Hansson J, Steineck G. The prevalance of loss of heterozygosity in chromosome 3, including FHIT, in bladder cancer, using the fluorescent multiplex polymerase chain reaction. BJU International 2001; 87: 876-881.