Selected Publications

Chen, D., Riedl, T., Washbrook, E., Pace, P. E., Coombes, R. C., Egly, J. M. and Ali, S. (2000) Activation of Estrogen Receptor _ by S118 Phosphorylation Involves a Ligand-Dependent Interaction with TFIIH and Participation of CDK7. Mol. Cell 6, 127-137.

Collado M, Medema RH, García-Cao I, Dubuisson MLN, Marta Barradas, Glassford J, Rivas C, Burgering BMT, Serrano M, and Lam EW-F Inhibition of the PI-3 kinase pathway induces a senescent-like arrest mediated by p27kip1. Journal of Biological Chemistry 275 21900-21968 (2000)

Smith, B.M., M.J. Slade, J.English, H. Graham, M. Luchtenborg, H.D. Sinnett, N.C. Cross, and R.C. Coombes. 2000. Response of circulating tumour cells to systemic therapy in patients with metastatic breast cancer: comparison of quantitative polymerase chain reaction and immunocytochemical techniques. J Clin Oncol. 18: 1432-1439.

Vigushin, D. M., Ali, S., Pace P. E., Mirsaidi, N., Ito, K., Adcock, I. and Coombes, R.C. (2001) Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo. Clin Cancer Res. 7, 971-976.

Wynn S. L, R.A. Fisher, C. Pagel, QY Liu, I.M.Khan, P Zammit, K. Dadrah, W Mazrani, A Kessling, JS. Lee, and L. Buluwela, "Genomic organisation of the GART-SON-3SG locus defines three genes in close proximity within the Down Syndrome Critical Region" Genomics, 2000 Aug 15;68(1):57-62.