Selected Publications

Antoni, L, Sodha N, Collins I, Garrett MD. CHK2: Cancer susceptibility and cancer therapy: two sides of the same coin? Nature Reviews Cancer 2007; 12: 925-936.

Saxty G, Woodhead SJ, Berdini V, Davies TG, Verdonk ML, Wyatt PG, Boyle RG, Barford D, Downham R, Garrett MD, Carr RA. Identification of inhibitors of protein kinase B using fragment-based lead discovery. J Med Chem 2007; 50: 2293-2296.

Donald A, McHardy T, Rowlands MG, Hunter LJ, Davies TG, Berdini V, Boyle RG, Aherne GW, Garrett MD, Collins I. Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design. J Med Chem 2007; 50: 2289-2292.

Sodha N, Mantoni TS, Tavtigian SV, Eeles R, Garrett MD. Rare germline CHEK2 variants identified in breast cancer families encode proteins that show impaired activation. Cancer Res 2006; 66: 8966-8970.

Mantoni T, Reid G, Garrett MD. Androgen receptor activity is inhibited in response to genotoxic agents in a p53-independent manner. Oncogene 2006; 25: 3139-3149.