Selected Publications

Batista FD, Iber D and Neuberger MS. B cells acquire antigen from target cells following synapse formation. Nature 2001; 411: 489-494. PubMed

Carrasco YR, Fleire SJ, Cameron T, Dustin ML and Batista FD. LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity 2004; 20: 589-599. PubMed

Smith A, Carrasco YR, Stanley P, Kieffer N, Batista FD and Hogg N. A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes. J Cell Biol 2005; 170: 141-151. PubMed

Fleire SJ, Goldman JP, Carrasco YR, Weber M, Bray D and Batista FD. B cell ligand discrimination through a spreading and contraction response. Science 2006; 312: 738-741. PubMed

Carrasco YR and Batista FD. B-cell activation by membrane-bound antigens is facilitated by the interaction of VLA-4 with VCAM-1. EMBO J 2006; 25: 889-899. PubMed PDF (UKPMC)

Primary Research Publications

2009

Batista FD, Harwood NE. The who, how and where of antigen presentation to B cells. Nat Rev Immunol. 2009 Jan;9(1):15-27.

Eckl-Dorna J, Batista FD. BCR-mediated uptake of antigen linked to TLR9-ligand stimulates B-cell proliferation and antigen-specific plasma cell formation. Blood. 2009 Jan 14. [Epub ahead of print]

Fleire SJ, Batista FD. Studying cell-to-cell interactions: an easy method of tethering ligands on artificial membranes. Methods Mol Biol. 2009;462:145-54.

Harwood NE, Batista FD. The antigen expressway: follicular conduits carry antigen to B cells. Immunity. 2009 Feb;30(2):177-9.

Depoil D, Weber M, Treanor B, Fleire SJ, Carrasco YR, Harwood NE, Batista FD. Early events of B cell activation by antigen. Sci Signal. 2009 Mar 24;2(63):pt1.

2008

Arana E, Vehlow A, Harwood NE, Vigorito E, Henderson R, Turner M, Tybulewicz VL, Batista FD. Activation of the small GTPase Rac2 via the B cell receptor regulates B cell adhesion and immunological-synapse formation. Immunity 2008;28(1):88-99

Barral P, Eckl-Dorna J, Harwood NE, De Santo C, Salio M, Illarionov P, Besra GS, Cerundolo V, Batista FD. B cell receptor-mediated uptake of CD1d-restricted antigen augments antibody responses by recruiting invariant NKT cell help in vivo. Proc Natl Acad Sci U S A 2008;105(24):8345-50

Depoil D, Fleire S, Treanor BL, Weber M, Harwood NE, Marchbank KL, Tybulewicz VL, Batista FD. CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. Nat Immunol 2008;9(1):63-72

Lin KB, Freeman SA, Zabetian S, Brugger H, Weber M, Lei V, Dang-Lawson M,Tse KW, Santamaria R, Batista FD, Gold MR. The rap GTPases regulate B cell morphology, immunesynapse formation, and signaling by particulate B cell receptor ligands. Immunity. 2008;28(1):75-87

Meyer-Bahlburg A, Becker-Herman S, Humblet-Baron S, Khim S,Weber M, Bouma G,Thrasher AJ, Batista FD, Rawlings DJ. Wiskott-Aldrich Syndrome protein deficiency in B cells results in impaired peripheral homeostasis. Blood 2008;112(10):4158-69

Weber M,Treanor B, Depoil D, Shinohara H, Harwood NE, Hikida M, Kurosaki T, Batista FD. Phospholipase C-gamma2 and Vav cooperate within signaling microclusters to propagate B cell spreading in response to membrane-bound antigen. J Exp Med 2008;205(4):853-68

2007

Carrasco YR, Batista FD. B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node. Immunity 2007; 27(1):160-171

McCarthy C, Shepherd D, Fleire S, Stronge VS, Koch M, Illarionov PA, Bossi G, Salio M, Denkberg G, Reddington F, Tarlton A, Reddy BG, Schmidt RR, Reiter Y, Griffi GM, van der Merwe PA, Besra GS, Jones EY, Batista FD, Cerundolo V. The length of lipids bound to human CD1d molecules modulates the affinity threshold of NKT cell activation. J Exp Med 2007; 204(5):1131-1144

2006

Carrasco YR, Batista FD. B-cell activation by membrane-bound antigens is facilitated by the interaction of VLA-4 with VCAM-1. EMBO J 2006; 25(4):889-899

Fleire SJ, Goldman JP, Carrasco YR, Weber M, Bray D, Batista FD. B cell ligand discrimination through a spreading and contraction response. Science 2006; 312(5774):738-741

2005

Smith A, Carrasco YR, Stanley P, Kieffer N, Batista FD, Hogg N. A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes. J Cell Biol 2005; 170(1):141-151

2004

Carrasco YR, Fleire SJ, Cameron T, Dustin ML, Batista FD. LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity 2004; 20(5):589-599

2002

Cumbers SJ, Williams GT, Davies SL, Grenfell RL, Takeda S, Batista FD, Sale JE, Neuberger MS. Generation and iterative affinity maturation of antibodies in vitro using hypermutating B-cell lines. Nat Biotechnol 2002; 20(11):1129-1134

Lanoue A, Batista FD, Stewart M, Neuberger MS. Interaction of CD22 with alpha 2,6-linked sialoglycoconjugates: innate recognition of self to dampen B cell autoreactivity? Eur J Immunol 2002; 32(2):348-355

Other Publications

Arana E, Harwood NE, Batista FD. Regulation of integrin activation through the B-cell receptor. J Cell Sci 2008;121(14):2279-86

Batista FD. Watching B cells spread and grab antigens. J Exp Med 2008;205(8):1718-9

Batista FD and Harwood NE. The who, how and where of antigen presentation to B cells. Nat Rev Immunol 2008;doi:10.1038/nri2454

Harwood NE, Batista FD. Insights into the early molecular events underlying B cell activation. Immunity. 2008;28(5):609-19

Harwood, NE and Batista, FD. Visualizing the molecular and cellular events underlying the initiation of B-cell activation. Curr Top Microbiol Immunol 2008: 334

Batista FD, Arana E, Barral P, Carrasco YR, Depoil D, Eckl-Dorna J, Fleire S, Howe K, Vehlow A, Weber M, Treanor B. The role of integrins and coreceptors in refining thresholds for B-cell responses. Immunol Rev 2007; 218:197-213

Treanor B, Batista FD. Mechanistic insight into lymphocyte activation through quantitative imaging and theoretical modelling. Curr Opin Immunol 2007; 19(4):476-483

Carrasco YR, Batista FD. B cell recognition of membrane-bound antigen: an exquisite way of sensing ligands. Curr Opin Immunol 2006; 18(3):286-291