Selected Publications
Nateri AS, Riera-Sans L, Da Costa C and Behrens A. The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 2004; 303: 1374-1378. PubMed
Raivich G, Bohatschek M, Da Costa C, Iwata O, Caliano M, Hristova M, Nateri AS, Makwana M, Riera-Sans L, Wolfer DP, Lipp H-P, Aguzzi A, Wagner EF, and Behrens A. The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron 2004; 43: 57-67. PubMed
Nateri AS, Spencer-Dene B and Behrens A. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 2005; 437: 281-285. PubMed
Lluís Riera-Sans and Axel Behrens. Regulation of αβ/γδ T cell lineage development by the AP-1 transcription factor c-Jun. J Immunology 2007: 178: 5690-5700. PubMed
Nnennaya Kanu and Axel Behrens. ATMIN defines a NBS1-independent pathway of ATM signalling. EMBO J 2007; 6: 2933-2941. PubMed
Nateri A, Raivich G, Gebhardt C, Da Costa C, Naumann H, Vreugdenhil M, Makwana M, Brandner S, Adams RH, Jefferys JGR, Kann O and Behrens A. ERK activation causes epilepsy by stimulating NMDA receptor activity. EMBO J 2007; 26(23): 4891-901.. PubMed
Primary Research Publications
2009
Sancho R, Nateri AS, de Vinuesa AG, Aguilera C, Nye E, Spencer-Dene B, Behrens A. JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. EMBO J 2009 Jul 8;28(13):1843-54. Epub 2009 Jun 11
2008
Kanu N, Behrens A. ATMINistrating ATM signalling: regulation of ATM by ATMIN Cell Cycle 2008;7(22):3483-6
Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML,Wrabetz L, Behrens A, Mirsky R, Jessen KR. c-Jun is a negative regulator of myelination. J Cell Biol 2008;181(4):625-37
2007
Kanu N, Behrens A. ATMIN defines an NBS1-independent pathway of ATM signalling. EMBO J 2007; 26(12):2933-2941
Nateri AS, Raivich G, Gebhardt C, Da Costa C, Naumann H, Vreugdenhil M, Makwana M, Brandner S, Adams RH, Jefferys JGR, Kann O, Behrens A. ERK activation causes epilepsy by stimulating NMDA receptor activity. EMBO J 2007; 26(23):4891-4901
Riera-Sans L, Behrens A. Regulation of alpha beta/gamma delta T cell development by the activator protein 1 transcription factor c-Jun. J Immunol 2007; 178(9):5690-5700
Vogel J, Weigand MA, Behrens A, Wayner EF, Schorpp-Kistner M, Zimmermann M, Schenkel J. Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action. Brain Res 2007; 1151:12-19
2005
Brecht S, Kirchhof R, Chromik A, Willesen M, Nicolaus T, Raivich G, Wessig J, Waetzig V, Goetz M, Claussen M, Pearse D, Kuan C-Y, Vaudano E, Behrens A, Wagner E, Flavell RA, Davis RJ, Herdegen T. Specific pathophysiological functions of JNK isoforms in the brain. Eur J Neurosci 2005; 21(2):363-377
Nateri AS, Spencer-Dene B, Behrens A. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 2005; 437(7056):281-285
2004
Genoud N, Behrens A, Miele G, Robay D, Heppner FL, Freigang S, Aguzzi A. Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions. Proc Natl Acad Sci U S A 2004; 101(12):4198-4203
Nateri AS, Riera-Sans L, Da Costa C, Behrens A. The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 2004; 303(5662):1374-1378
Raivich G, Bohatschek M, Da Costa C, Iwata O, Galiano M, Hristova M, Nateri AS, Makwana M, Riera-Sans L, Wolfer DP, Lipp HP, Aguzzi A, Wagner EF, Behrens A. The AP-1 transcription factor c-Jun is required for efficient axonal regeneration. Neuron 2004; 43(1):57-67
2003
Behrens A, Haigh J, Mechta-Grigoriou F, Nagy A, Yaniv M, Wagner EF. Impaired intervertebral disc formation in the absence of Jun. Development 2003; 130(1):103-109
2002
Behrens A, Genoud N, Naumann H, Rulicke T, Janett F, Heppner FL, Ledermann B, Aguzzi A. Absence of the prion protein homologue Doppel causes male sterility. EMBO J 2002; 21(14):3652-3658
Behrens A, Sibilia M, David JP, Mohle-Steinlein U, Tronche F, Schutz G, Wagner EF. Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J 2002; 21(7):1782-1790
Passegue E, Jochum W, Behrens A, Ricci R, Wagner EF. JunB can substitute for Jun in mouse development and cell proliferation. Nat Genet 2002; 30(2):158-166
Other Publications
Raivich G, Behrens A. Role of the AP-1 transcription factor c-Jun in developing, adult and injured brain. Prog Neurobiol 2006; 78(6):347-363
Behrens A. Physiological and pathological functions of the prion protein homologue Dpl. Br Med Bull 2003; 66:35-42
Behrens A, Aguzzi A. Small is not beautiful: antagonizing functions for the prion protein PrPC and its homologue Dpl. Trends Neurosci 2002; 25(3):150-154
