Selected Publications
Bonnet D and Dick JE. Human acute leukemia is organized as a hierarchy, which originates from a primitive hematopoietic cell. Nature Medicine 1997; 3: 730-737. PubMed
Taussig DC, Oearce DJ, Simpson C, Rohatiner AZ, Lister TA, Kelly G, Luongo JL, Danet-Desnoyers GH and Bonnet D. Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood 2005; 106: 4086-4092. PubMed Full text
Pearce DJ, Taussig D, Zibara K, Smith L-L, Ridler CM, Preudhomme C, Young BD, Rohatiner AZ, Lister TA and Bonnet D. AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML. Blood 2006; 107: 1166-1173. PubMed Full text
Rangatia J and Bonnet D. Transient or long-term silencing of BCR-ABL alone induces cell cycle and proliferation arrest, apoptosis and differentiation. Leukemia 2006; 20: 68-76. PubMed
Kashofer K, Siapati EK and Bonnet D. In vivo formation of unstable heterokaryons after liver damage and hematopoietic stem cell/ progenitor transplantation. Stem Cells 2006; 24: 1104-1112. PubMed
Primary Research Publications
2009
Pearce D, Bonnet D. Ageing within the hematopoietic stem cell compartment. Mech Ageing Dev. 2009 Jan-Feb;130(1-2):54-7.
Bonnet D. Humanized mouse models to study the human haematopoietic stem cell compartment. Methods Mol Biol. 2009;506:331-40.
Oke A, Pearce D, Wilkinson RW, Crafter C, Odedra R, Cavenagh J, Fitzgibbon J, Lister AT, Joel S, Bonnet D. AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo. Cancer Res. 2009 May 15;69(10):4150-8
Boxall SA, Cook GP, Pearce D, Bonnet D, El-Sherbiny YM, Blundell MP, Howe SJ, Leek JP, Markham AF, de Wynter EA. Haematopoietic repopulating activity in human cord blood CD133+ quiescent cells. Bone Marrow Transplant. 2009 Apr;43(8):627-35.
Bonnet D. Humanized model to study leukemic stem cells. Methods Mol Biol. 2009;538:1-16.
2008
Boxall SA, Cook GP, Pearce D, Bonnet D, El-Sherbiny YM, Blundell MP, Howe SJ, Leek JP, Markham AF, de Wynter EA. Haematopoietic repopulating activity in human cord blood CD133(+) quiescent cells. Bone Marrow Transplantation 2008;doi:10.1038/bmt.2008.368
Taussig DC, Miraki-Moud F, Anjos-Afonso F, Pearce DJ, Allen K, Ridler C, Lillington D, Oakervee H, Cavenagh J, Agrawal SG, Lister TA, Gribben JG, Bonnet D. Anti-CD38 antibodymediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells Blood 2008;112(3):568-75
Virappane P, Gale R, Hills R, Kakkas I, Summers K, Stevens J, Allen C, Green C, Quentmeier H, Drexler H, Burnett A, Linch D, Bonnet D, Lister TA, Fitzgibbon J. Mutation of the Wilms¿ Tumor 1 Gene Is a Poor Prognostic Factor Associated With Chemotherapy Resistance in Normal Karyotype Acute Myeloid Leukemia:The United Kingdom Medical Research Council Adult Leukaemia Working Party. J Clin Oncol 2008;26(33):5429-35
2007
Aguilar S, Nye E, Chan J, Loebinger M, Spencer-Dene B, Fisk N, Stamp G, Bonnet D, Janes SM. Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung. Stem Cells 2007; 25(6):1586-1594
Anjos-Afonso F, Bonnet D. Nonhematopoietic/endothelial SSEA-1(+) cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment. Blood 2007; 109(3):1298-1306
Pearce DJ, Anjos-Afonso F, Ridler CM, Eddaoudi A, Bonnet D. Age-dependent increase in side population distribution within hematopoiesis: Implications for our understanding of the mechanism of aging. Stem Cells 2007; 25(4):828-835
Pearce DJ, Bonnet D. The combined use of Hoechst efflux ability and aldehyde dehydrogenase activity to identify murine and human hematopoietic stem cells. Exp Hematol 2007; 35(9):1437-1446
Ramasamy R, Lam EWF, Soeiro I, Tisato V, Bonnet D, Dazzi F. Mesenchymal stem cells inhibit proliferation and apoptosis of tumor cells: impact on in vivo tumor growth. Leukemia 2007; 21(2):304-310
Siapati EK, Bigger BW, Kashofer K, Themis M, Thrasher AJ, Bonnet D. Murine leukemia following irradiation conditioning for transplantation of lentivirally-modified hematopoietic stem cells. Eur J Haematol 2007; 78(4):303-313
2006
Bigger BW, Siapati EK, Mistry A, Waddington SN, Nivsarkar MS, Jacobs L, Perrett R, Holder MV, Ridler C, Kemball-Cook G, Ali RR, Forbes SJ, Coutelle C, Wright N, Alison M, Thrasher AJ, Bonnet D, Themis M. Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX. Gene Ther 2006; 13(2):117-126
Kashofer K, Siapati EK, Bonnet D. in vivo formation of unstable heterokaryons after liver damage and hematopoietic stem cell/progenitor transplantation. Stem Cells 2006; 24(4):1104-1112
Pearce DJ, Taussig D, Zilbara K, Smith L-L, Ridler CM, Preudhomme C, Young BD, Rohatiner AZ, Lister TA, Bonnet D. AML engraftment in the NOD/SCID assay reflects the outcome of AML: implications for our understanding of the heterogeneity of AML. Blood 2006; 107(3):1166-1173
Pearce DJ, Taussig DC, Bonnet D. Implications of the expression of myeloid markers on normal and leukemic stem cells. Cell Cycle 2006; 5(3):271-273
Rangatia J, Bonnet D. Transient or long-term silencing of BCR-ABL alone induces cell cycle and proliferation arrest, apoptosis and differentiation. Leukemia 2006; 20(1):68-76
Simpson C, Pearce DJ, Bonnet D, Davies D. Out of the blue: a comparison of Hoechst side population (SP) analysis of murine bone marrow using 325, 363 and 407 nm excitation sources. J Immunol Methods 2006; 310(1-2):171-181
2005
Danet-Desnoyers GH, Luongo JL, Bonnet DA, Domchek SM, Vonderheide RH. Telomerase vaccination has no detectable effect on SCID-repopulating and colony-forming activities in the bone marrow of cancer patients. Exp Hematol 2005; 33(11):1275-1280
Pearce DJ, Taussig D, Simpson C, Allen K, Rohatiner AZ, Lister TA, Bonnet D. Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples. Stem Cells 2005; 23(6):752-760
Siapati EK, Bigger BW, Miskin J, Chipchase D, Parsley KL, Mitrophanous K, Themis M, Thrasher AJ, Bonnet D. Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells. Mol Ther 2005; 12(3):537-546
Smith ML, Arch R, Smith L-L, Bainton N, Neat M, Taylor C, Bonnet D, Cavenagh JD, Lister TA, Fitzgibbon J. Development of a human acute myeloid leukaemia screening panel and consequent identification of novel gene mutation in FLT3 and CCND3. Br J Haematol 2005; 128(3):318-323
Spencer H, Rampling D, Aurora P, Bonnet D, Hart SL, Jaffe A. Transbronchial biopsies provide longitudinal evidence for epithelial chimerism in children following sex mismatched lung transplantation. Thorax 2005; 60(1):60-62
Taussig DC, Pearce DJ, Simpson C, Rohatiner AZ, Lister TA, Kelly G, Luongo JL, Danet-Desnoyers GH, Bonnet D. Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia. Blood 2005; 106(13):4086-4092
2004
Anjos-Afonso F, Siapati EK, Bonnet D. in vivo contribution of murine mesenchymal stem cells into multiple cell-types under minimal damage conditions. J Cell Sci 2004; 117(23):5655-5664
Pearce DJ, Ridler CM, Simpson C, Bonnet D. Multiparameter analysis of murine bone marrow side population cells. Blood 2004; 103(7):2541-2546
2003
Danet GH, Pan Y, Luongo JL, Bonnet DA, Simon MC. Expansion of human SCID-repopulating cells under hypoxic conditions. J Clin Invest 2003; 112(1):126-135
2002
Danet GH, Luongo JL, Butler G, Lu MM, Tenner AJ, Simon MC, Bonnet DA. C1qR(p) defines a new human stem cell population with hernatopoietic and hepatic potential. Proc Natl Acad Sci U S A 2002; 99(16):10441-10445
Other Publications
Anjos-Afonso F, Bonnet D. Isolation, culture, and differentiation potential of mouse marrow stromal cells. Curr Protoc Stem Cell Biol 2008;Chapter 2:Unit 2B.3
Bonnet D. in vivo evaluation of Leukemic Stem Cells through xenotransplanation model Curr Protoc Stem Cell Bio 2008;Chapter 3:Unit 3.2
Owen C,Virappane P, Alikian M, Stasevich I, Summers K, Lillington D, Bonnet D, Burnett A, Mills K, Lister TA, Fitzgibbon J. WTX is rarely mutated in acute myeloid leukemia. Haematologica 2008;93(6):947-8
Pearce D, Bonnet D. Ageing within the hematopoietic stem cell compartment. Mech Ageing Dev 2008; doi:10.1016/j.mad.2008.04.005
Anjos-Afonso F, Bonnet D. Flexible and dynamic organization of bone marrow stromal compartment. Br J Haematol 2007; 139(3):373-384
Pearce DJ, Bonnet D. Leukemia stem cells: studying the root of leukemia. Gene Ther Regul 2007; 3(1):65-90
Summers K, Stevens J, Kakkas I, Smith M, Smith LL, MacDougall F, Cavenagh J, Bonnet D, Young BD. Wilms' tumour 1 mutations are associated with FLT3-ITD and failure of standard induction chemotherapy in patients with normal karyotype AML. Leukemia 2007; 21(3):550-551
Smith L-L, Pearce D, Smith ML, Jenner M, Lister TA, Bonnet D, Goff L, Fitzgibbon J. Development of a quantitative real-time polymerase chain reaction method for monitoring CEBPA mutations in normal karyotype acute myeloid leukaemia. Br J Haematol 2006; 133(1):103-105
Bonnet D. Cancer stem cells: AMLs show the way. Biochem Soc Trans 2005; 33(6):1531-1533
Bonnet D. Cancer stem cells: lessons from leukaemia. Cell Prolif 2005; 38(6):357-361
Bonnet D. Cancer stem cells: preface to the third issue of Stem Cell Reviews. Stem Cell Rev 2005; 1(3):179-180
Bonnet D. Leukemic stem cells show the way. Folia Histochem Cytobiol 2005; 43(4):183-186
Bonnet D. Normal and leukaemic stem cells. Br J Haematol 2005; 130(4):469-479
Griffiths MJD, Bonnet D, Janes SM. Stem cells of the alveolar epithelium. Lancet 2005; 366(9481):249-260
Kashofer K, Bonnet D. Gene therapy progress and prospects: stem cell plasticity. Gene Ther 2005; 12(16):1229-1234
Bonnet D. Biology of human bone marrow stem cells. Clin Exp Med 2003; 3(3):140-149
Bonnet D. Hematopoietic stem cells. Birth Defects Res Part C Embryo Today 2003; 69:219-229
Bonnet D. Haematopoietic stem cells. J Pathol 2002; 197(4):430-440
Taussig DC, Pearce DJ, Bonnet DA. Male cells in female recipients of hematopoietic-cell transplants. N Engl J Med 2002; 347(3):219-219
