Selected Publications
Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ. Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1. Science, 2009 Aug 6. [Epub ahead of print]. PubMed
Ahel I, Ahel D, Matsusaka T, Clark AJ, Pines J, Boulton SJ, West SC. Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature 2008;451(7174):81-85. PubMed
Barber LJ,Youds JL,Ward JD, McIlwraith MJ, O'Neil NJ, Petalcorin MI, Martin JS, Collis SJ, Cantor SB,Auclair M, Tissenbaum H,West SC, Rose AM, Boulton SJ. RTEL1 maintains genomic stability by suppressing homologous recombination. Cell 2008;135(2):261-271. PubMed
Collis SJ, Ciccia A, Deans AJ, Horejsí Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ. FANCM-FAAP24 function in ATR-mediated checkpoint signalling independently of the Fanconi Anemia core complex. Mol Cell 2008; 32(3):313-324. PubMed
Ward JD, Barber LJ, Petalcorin MI, Yanowitz J, Boulton SJ. Replication blocking lesions present a unique substrate for homologous recombination. EMBO J 2007; 26(14):3384-3396. PubMed
Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Xin W, Kobayashi M, Yamamoto K, Boulton SJ and Takeda S. A critical role for the ubiquitin-conjugating enzyme UBC13 in initiating homologous recombination. Mol Cell 2007; 25: 663-675. PubMed
Collis SJ, Barber LJ, Martin JS, Ward JD and Boulton SJ. HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. Nature Cell Biology 2007; 9; 391-401. PubMed
Primary Research Publications
2009
Ahel D, Horejsí Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ. Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1. Science, 2009 Aug 6. [Epub ahead of print].
Pauklin S, Burkert JS, Martin J, Osman F, Weller S, Boulton S, Whitby MC, Petersen-Mahrt SK. Alternative Induction of Meiotic Recombination from Single Base Lesions of DNA Deaminases. Genetics. 2009 Feb 24
Horejŝí Z, Collis SJ, Boulton SJ. FANCM-FAAP24 and HCLK2: roles in ATR signalling and the Fanconi anemia pathway. Cell Cycle. 2009 Apr 15;8(8):1133-7. Epub 2009 Apr 16
2008
Adamo A, Montemauri P, Silva N,Ward JD, Boulton SJ, La Volpe A. BRC-1 acts in the inter-sister pathway of meiotic double-strand break repair. EMBO Rep. 2008;9(3):287-92
Ahel I,Ahel D, Matsusaka T, Clark AJ, Pines J, Boulton SJ, West SC. Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature. 2008;451(7174):81-5
Barber LJ,Youds JL,Ward JD, McIlwraith MJ, OżNeil NJ, Petalcorin MI, Martin JS, Collis SJ, Cantor SB,Auclair M, Tissenbaum H,West SC, Rose AM, Boulton SJ. RTEL1 maintains genomic stability by suppressing homologous recombination. Cell. 2008;135(2):261-71
Collis SJ, Ciccia A, Deans AJ, Horejsí Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ. FANCM-FAAP24 function in ATR-mediated checkpoint signalling independently of the Fanconi Anemia core complex. Mol Cell; 32(3):313-24
Goodyer W, Kaitna S, Couteau F,Ward JD, Boulton SJ, Zetka M. HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis. Dev Cell 2008;14(2):263-74
London TB, Barber LJ, Mosedale G, Kelly GP, Balasubramanian S, Hickson ID, Boulton SJ, Hiom K. FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts. J. Biol. Chem. 2008;283(52):36132-9
Muzzini DM, Plevani P, Boulton SJ, Cassata G, Marini F. Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways. DNA Repair (Amst) 2008;7(6):941-50
Wan L, Niu H, Futcher B, Zhang C, Shokat KM, Boulton SJ, Hollingsworth NM. Cdc28-Clb5 (CDK-S) and Cdc7-Dbf4 (DDK) collaborate to initiate meiotic recombination in yeast. Genes Dev. 2008;22(3):386-97
Youds JL, Barber LJ,Ward JD, Collis SJ, OżNeil NJ, Boulton SJ, Rose AM. DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand crosslink repair. Mol Cell Biol. 2008;28(5):1470-9
2007
Collis SJ, Barber LJ, Clark AJ, Martin JS, Ward JD, Boulton SJ. HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability. Nat Cell Biol 2007; 9(4):391-U62
Murakawa Y, Sonoda E, Barber LJ, Zeng W, Yokomori K, Kimura H, Niimi A, Lehmann A, Zhao GY, Hochegger H, Boulton SJ, Takeda S. Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells. Cancer Res 2007; 67(18):8536-8543
Petalcorin MIR, Galkin VE, Yu X, Egelman EH, Boulton SJ. Stabilization of RAD-51-DNA filaments via an interaction domain in Caenorhabditis elegans BRCA2. Proc Natl Acad Sci U S A 2007; 104(20):8299-8304
Ward JD, Barber LJ, Petalcorin MIR, Yanowitz J, Boulton SJ. Replication blocking lesions present a unique substrate for homologous recombination. EMBO J 2007; 26(14):3384-3396
Zhao GY, Sonoda E, Barber LJ, Oka H, Murakawa Y, Yamada K, Ikura T, Wang X, Kobayashi M, Yamamoto K, Boulton SJ, Takeda S. A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination. Mol Cell 2007; 25(5):663-675
2006
Collis SJ, Barber LJ, Ward JD, Martin JS, Boulton SJ. C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair. DNA Repair 2006; 5(11):1398-1406
Dengg M, Garcia-Muse T, Gill SG, Ashcroft N, Boulton SJ, Nilsen H. Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates. EMBO Rep 2006; 7(10):1046-1051
Petalcorin MIR, Sandall J, Wigley DB, Boulton SJ. CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing. J Mol Biol 2006; 361(2):231-242
Polanowska J, Martin JS, Garcia-Muse T, Petalcorin MIR, Boulton SJ. A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. EMBO J 2006; 25(10):2178-2188
2005
Garcia-Muse T, Boulton SJ. Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans. EMBO J 2005; 24(24):4345-4355
Martin JS, Winkelmann N, Petalcorin MIR, McIlwraith MJ, Boulton SJ. RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair. Mol Cell Biol 2005; 25(8):3127-3139
2004
Boulton SJ, Martin JS, Polanowska J, Hill DE, Gartner A, Vidal M. BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans. Curr Biol 2004; 14(1):33-39
Polanowska J, Martin JS, Fisher R, Scopa T, Rae I, Boulton SJ. Tandem immunoaffinity purification of protein complexes from Caenorhabditis elegans. Biotechniques 2004; 36(5):778-782
2003
Huang RY, Boulton SJ, Vidal M, Almo SC, Bresnick AR, Chance MR. High-throughput expression, purification, and characterization of recombinant Caenorhabditis elegans proteins. Biochem Biophys Res Commun 2003; 307(4):928-934
Reboul J, Vaglio P, Rual J-F, Lamesch P, Martinez M, Armstrong CM, Li SM, Jacotot L, Bertin N, Janky R, Moore T, Hudson JR, Hartley JL, Brasch MA, Vandenhaute J, Boulton S, Endress GA, Jenna S, Chevet E, Papasotiropoulos V, Tolias PP, Ptacek J, Snyder M, Huang R, Chance MR, Lee HM, Doucette-Stamm L, Hill DE, Vidal M C-elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression. Nat Genet 2003; 34(1):35-41
2002
Boulton SJ, Gartner A, Reboul J, Vaglio P, Dyson N, Hill DE, Vidal M. Combined functional genomic maps of the C-elegans DNA damage response. Science 2002; 295(5552):127-131
Hofmann ER, Milstein S, Boulton SJ, Ye MJ, Hofmann JJ, Stergiou L, Gartner A, Vidal M, Hengartner MO. Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis. Curr Biol 2002; 12(22):1908-1918
Other Publications
Boulton SJ. Differential regulation of the PIKK kinase family by Tel2, Cell Cycle 2008;7(23):3617
Youds JL, Barber LJ, Boulton SJ. C. elegans as a model for the Fanconi repair pathway. Mutat Res. 2008;doi:10.1016/j.mrfmmm.2008.11.007
Aguilera A, Boulton SJ. How to exchange your partner. Workshop on recombination mechanisms and the maintenance of genomic stability. EMBO Rep 2007; 8(1):28-33
Collis SJ, Boulton SJ. Emerging links between the biological clock and the DNA damage response. Chromosoma 2007; 116(4):331-339
Garcia-Muse T, Boulton SJ. Meiotic recombination in Caenorhabditis elegans. Chromosome Res 2007; 15(5):607-621
Barber LJ, Boulton SJ. BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg? DNA Repair 2006; 5(12):1499-1504
Boulton SJ. BRCA1-mediated ubiquitylation. Cell Cycle 2006; 5(14):1481-1486
Boulton SJ. Cellular functions of the BRCA tumour-suppressor proteins. Biochem Soc Trans 2006; 34(Pt 5):633-645
Collis SJ, DeWeese TL, Jeggo PA, Parker AR. The life and death of DNA-PK. Oncogene 2005; 24(6):949-961
Chance MR, Bresnick AR, Burley SK, Jiang JS, Lima CD, Sali A, Almo SC, Bonanno JB, Buglino JA, Boulton S, Chen H, Eswar N, He GS, Huang R, Ilyin V, McMahan L, Pieper U, Ray S, Vidal M, Wang LK. Structural genomics: A pipeline for providing structures for the biologist. Protein Sci 2002; 11(4):723-738
