Selected Publications

Costanzo V, Robertson K, Ying CY, Kim E, Avvedimento E, Gottesman M, Grieco D and Gautier J. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol Cell 2000; 6: 649-659. PubMed

Costanzo V, Robertson K, Bibikova M, Kim E, Grieco D, Gottesman M, Carroll D and Gautier J. Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. Mol Cell 2001; 8: 137-147. PubMed

Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M and Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell 2003; 11: 203-213. PubMed

Costanzo V and Gautier J. Xenopus cell-free extracts to study DNA damage checkpoints. Meth Mol Biol 2003; 241: 255-268. PubMed

Costanzo V, Paull T, Gottesman and Gautier J. Mre11 assembles linear DNA fragments into DNA damage signaling complexes. PLoS Biol 2004; 2: 0600-0609 & 0876 PubMed PDF (UKPMC)

Primary Research Publications

2009

Smith E, Dejsuphong D, Balestrini A, Hampel M, Lenz C, Takeda S, Vindigni A, Costanzo V. An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63. Nat Cell Biol. 2009 Mar;11(3):278-85

Garner E, Costanzo V. Studying the DNA damage response using in vitro model systems. DNA Repair (Amst). 2009 May 22.

Russo I, Cosentino C, Del Giudice E, Broccoletti T, Amorosi S, Cirillo E, Aloj G, Fusco A, Costanzo V, Pignata C. In ataxia-teleangiectasia betamethasone response is inversely correlated to cerebellar atrophy and directly to antioxidative capacity. Eur J Neurol. 2009 Jun;16(6):755-9

2008

Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V. Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J 2008;27(14):1953-62

Trenz K, Errico A, Costanzo V. Plx1 is required for chromosomal DNA replication under stressful conditions. EMBO J 2008;27(6):876-85

2007

D'Angiolella V, Palazzo L, Santarpia C, Costanzo V, Grieco D. Role for non-proteolytic control of M-phase promoting factor activity at M-phase exit. PLoS ONE 2007; 2: e247.

Errico A, Costanzo V, Hunt T. Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. Proc Natl Acad Sci U S A 2007; 104(38):14929-14934

2006

Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, Hoatlin ME. Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks. Mol Cell Biol 2006; 26(2):425-437

Trenz K, Smith E, Smith S, Costanzo V. ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J 2006; 25(8):1764-1774

Other Publications

Brown N, Costanzo V. An ATM and ATR dependent pathway targeting centrosome dependent spindle assembly. Cell Cycle 2009 Jul 1;8(13):1997-2001.

Costanzo V, Chaudhuri J, Fung JC, Moran JV. Dealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair. EMBO Rep 2009 Aug;10(8):837-42

Smith E, Costanzo V. Responding to chromosomal breakage during M-phase: insights from a cell-free system. Cell Div 2009 Jul 14;4:15

Pentimalli F, Palmieri D, Pacelli R, Garbi C, Cesari R, Martin E, Pierantoni GM, Chieffi P, Croce CM, Costanzo V, Fedele M, Fusco A. HMGA1 protein is a novel target of the ATM kinase. Eur J Cancer. 2008;44(17):2668-79

Takaki T, Trenz K, Costanzo V, Petronczki M. Polo-like kinase 1 reaches beyond mitosis-cytokinesis, DNA damage response, and development. Curr Opin Cell Biol 2008;20(6):650-60