Selected Publications
Labib K, Tercero JA and Diffley JFX. Uninterrupted MCM2-7 function required for DNA replication fork progression. Science 2000; 288: 1643-1647. PubMed
Tanaka S and Diffley JFX. Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation. Genes Dev 2002; 16: 2639-2649. PubMed Full text
Tercero JA and Diffley JFX. Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 2001; 412: 553-557. PubMed
Tercero JA, Longhese MP, Diffley JFX. A central role for DNA replication forks in checkpoint activation and response. Mol Cell 2003; 11: 1323-1336. PubMed
Mimura S, Seki T, Tanaka S, Diffley JFX. Phosphoylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature 2004; 431: 1118-1123. PubMed
Primary Research Publications
2009
Drury LS, Diffley JF. Factors affecting the diversity of DNA replication licensing control in eukaryotes. Curr Biol. 2009 Mar 24;19(6):530-5.
2008
Baxter J, Diffley JF. Topoisomerase II inactivation prevents the completion of DNA replication in budding yeast. Mol Cell 2008;30(6):790-802
Segurado M, Diffley JF. Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks. Genes Dev 2008;22(13):1816-27
Zierhut C, Diffley JF. Break dosage, cell cycle stage and DNA replication influence DNA double strand break response. EMBO J 2008;27(13):1875-85
2007
Zegerman P, Diffley JFX. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast. Nature 2007; 445(7125):281-285
2005
Mailand N, Diffley JFX. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell 2005; 122(6):915-926
2004
Early A, Drury LS, Diffley JFX. Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage. Philos Trans R Soc Lond B Biol Sci 2004; 359(1441):31-38
Merrick CJ, Jackson D, Diffley JFX. Visualization of altered replication dynamics after DNA damage in human cells. J Biol Chem 2004; 279(19):20067-20075
Mimura S, Seki T, Tanaka S, Diffley JFX. Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature 2004; 431(7012):1118-1123
Wang XA, Ira G, Tercero JA, Holmes AM, Diffley JFX, Haber JE. Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae. Mol Cell Biol 2004; 24(16):6891-6899
2003
Okuzaki D, Watanabe T, Tanaka S, Nojima H. The Saccharomyces cerevisiae bud-neck proteins Kcc4 and Gin4 have distinct but partially-overlapping cellular functions. Genes Genet Syst 2003; 78(2):113-126
Tercero JA, Longhese MP, Diffley JFX. A central role for DNA replication forks in checkpoint activation and response. Mol Cell 2003; 11(5):1323-1336
2002
Tanaka S, Diffley JFX. Deregulated G(1)-cyclin expression induces genomic instability by preventing efficient pre-RC formation. Genes Dev 2002; 16(20):2639-2649
Tanaka S, Diffley JFX. Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat Cell Biol 2002; 4(3):198-207
Other Publications
Zegerman P, Diffley JF DNA replication as a target of the DNA damage checkpoint. DNA Repair (Amst) 2009 Sep 2;8(9):1077-88
Diffley JFX. Regulation of early events in chromosome replication. Curr Biol 2004; 14(18):R778-R786
Vernis L, Piskur J, Diffley JFX. Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae. Nucleic Acids Res 2003; 31(19):e120
Zegerman P, Diffley JFX. Lessons in how to hold a fork. Nat Struct Biol 2003; 10(10):778-779
Diffley JFX, Labib K. The chromosome replication cycle. J Cell Sci 2002; 115(5):869-872
