Selected Publications
Inman GJ, Nicolás FJ and Hill CS. Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity. Mol. Cell 2002; 10: 283-294. PubMed
Ross S, Cheung E, Petrakis TG, Howell M, Kraus WL and Hill CS. Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J, e-published 21 Sep 2006, doi:10.1038/sj.emboj.7601332. PubMed PDF (UKPMC)
Dorey K and Hill CS. A novel Cripto-related protein reveals an essential role for EGF-CFCs in nodal signalling in Xenopus embryos. Dev Biol 2006; 292: 303-316. PubMed
Levy L and Hill CS. Smad4 dependency defines two classes of transforming growth factor β (TGF-β) target genes and distinguishes TGF-β-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol 2005; 25: 8108-8125. PubMed PDF (UKPMC)
Schmierer B and Hill CS. Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor β-dependent nuclear accumulation of Smads. Mol Cell Biol 2006; 25: 9845-9858. PubMed PDF (UKPMC)
Primary Research Publications
2009
Das D, Randall RA, Hill CS. An N-terminally truncated Smad2 protein can partially compensate for loss of full-length Smad2. Biochem J. 2009 Jan 1;417(1):205-12.
Hill CS. Nucleocytoplasmic shuttling of Smad proteins. Cell Res. 2009 Jan;19(1):36-46.
Wu MY, Hill CS. Tgf-Beta superfamily signaling in embryonic development and homeostasis. Dev Cell. 2009 Mar;16(3):329-43.
2008
Batut J, Schmierer B, Cao J, Raftery LA, Hill CS, Howell M. Two highly related regulatory subunits of PP2A exert opposite effects on TGF-β/Activin/Nodal signaling. Development 2008;135(17):2927-37
Daly AC, Randall RA, Hill CS. Transforming growth factor β-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth. Mol Cell Biol 2008;28(22):6889-902
Das D, Randall RA, Hill CS. An N-terminally truncated Smad2 protein can partially compensate for loss of full-length Smad2. Biochem J 2008;[PMID: 18764783]
de Almeida I, Rolo A, Batut J, Hill C, Stern CD, Linker C. Unexpected activities of Smad7 in Xenopus mesodermal and neural induction. Mech Dev 2008;125(5-6):421-31
Schmierer B,Tournier AL, Bates PA, Hill CS. Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system. Proc Natl Acad Sci U S A 2008;105(18):6608-13
2007
Batut J, Howell M, Hill CS. Kinesin-mediated transport of Smad2 is required for signaling in response to TGF-beta Ligands. Dev Cell 2007; 12(2):261-274
Biondi CA, Das D, Howell M, Islam A, Bikoff EK, Hill CS, Robertson EJ. Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling. Biochem J 2007; 404(Pt 2):235-245
Levy L, Howell M, Das D, Harkin S, Episkopou V, Hill CS. Arkadia activates Smad3/Smad4-Dependent transcription by triggering signal-induced SnoN degradation. Mol Cell Biol 2007; 27(17):6068-6083
2006
Dorey K, Hill CS. A novel Cripto-related protein reveals an essential role for EGF-CFCs in nodal signalling in Xenopus embryos. Dev Biol 2006; 292(2):303-316
Ross S, Cheung E, Petrakis TG, Howell M, Kraus WL, Hill CS. Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J 2006; 25(19):4490-4502
2005
Bilioni A, Craig G, Hill C, McNeill H. Iroquois transcription factors recognize a unique motif to mediate transcriptional repression in vivo. Proc Natl Acad Sci U S A 2005; 102(41):14671-14676
Levy L, Hill CS. Smad4 dependency defines two classes of transforming growth factor beta (TGF-beta) target genes and distinguishes TGF-beta-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol 2005; 25(18):8108-8125
Schmierer B, Hill CS. Kinetic analysis of Smad nucleocytoplasmic shuttling reveals a mechanism for transforming growth factor beta-dependent nuclear accumulation of Smads. Mol Cell Biol 2005; 25(22):9845-9858
2004
De Bosscher K, Hill CS, Nicolas FJ. Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells. Biochem J 2004; 379(Pt 1):209-216
Nicolas FJ, De Bosscher K, Schmierer B, Hill CS. Analysis of Smad nucleocytoplasmic shuttling in living cells. J Cell Sci 2004; 117(18):4113-4125
Randall RA, Howell M, Page CS, Daly A, Bates PA, Hill CS. Recognition of phosphorylated-Smad2-containing complexes by a novel Smad interaction motif. Mol Cell Biol 2004; 24(3):1106-1121
2003
Nicolas FJ, Hill CS. Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest. Oncogene 2003; 22(24):3698-3711
Nicolas FJ, Lehmann K, Warne PH, Hill CS, Downward J. Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrest. J Biol Chem 2003; 278(5):3251-3256
2002
Howell M, Inman GJ, Hill CS. A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements. Development 2002; 129(12):2823-2834
Inman GJ, Hill CS. Stoichiometry of active Smad-transcription factor complexes on DNA. J Biol Chem 2002; 277(52):51008-51016
Inman GJ, Nicolas FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 2002; 62(1):65-74
Inman GJ, Nicolas FJ, Hill CS. Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-beta receptor activity. Mol Cell 2002; 10(2):283-294
Randall RA, Germain S, Inman GJ, Bates PA, Hill CS. Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. EMBO J 2002; 21(1-2):145-156
Other Publications
Ross S, Hill CS. How the Smads regulate transcription. Int J Biochem Cell Biol 2008; 40(3):383-408
Schmierer B, Hill CS. TGF beta-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 2007; 8(12):970-982
Hill CS. Identification of a Smad phosphatase. ACS Chem Biol 2006; 1(6):346-348
Hill CS. Turning off Smads: identification of a Smad phosphatase. Dev Cell 2006; 10(4):412-413
Levy L, Hill CS. Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev 2006; 17(1-2):41-58
ten Dijke P, Hill CS. New insights into TGF-beta-Smad signalling. Trends Biochem Sci 2004; 29(5):265-273
