Selected Publications

Mochida S and Hunt T. Calcineurin is required to release Xenopus egg extracts from meiotic M phase. Nature 2007; 449: 336-340. PubMed

Errico A, Costanzo V and Hunt T. Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. Proc Natl Acad Sci USA 2007; 104: 14929-14934. PubMed PDF (UKPMC)

Hochegger H, Dejsuphong D, Sonoda E, Saberi A, Rajendra E, Kirk J, Hunt T and Takeda S. An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells. J Cell Biol 2007; 178: 257-268. PubMed PDF (UKPMC)

Hunt T and Sassone-Corsi P. Riding tandem: circadian clocks and the cell cycle. Cell 2007; 129: 461-464. PubMed

Petri ET, Errico A, Escobedo L, Hunt T and Basavappa R. The Crystal Structure of Human Cyclin B. Cell Cycle 2007; 6: 1342-1349. PubMed

Primary Research Publications

2009

Mochida S, Ikeo S, Gannon J, Hunt T. Regulated activity of PP2A-B55delta is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts. EMBO J 2009 Aug 20

Takaki T, Echalier A, Brown NR, Hunt T, Endicott JA, Noble ME. The structure of CDK4/cyclin D3 has implications for models of CDK activation. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4171-6.

2008

Fang TC, Otto WR, Rao J, Jeffery R, Hunt T, Alison MR, Cook HT, Wright NA, Poulsom R. Haematopoietic lineage-committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl(2)-induced acute tubular injury. Cell Prolif 2008 Jun 19. [Epub ahead of print]

Hunt T, Vogler AP. A protocol for large-scale rRNA sequence analysis: Towards a detailed phylogeny of Coleoptera. Mol Phylogenet Evol 2008; 47(1):289-301

Kimata Y,Trickey M, Izawa D, Gannon J,Yamamoto M, Yamano H. A mutual inhibition between APC/C and its substrate Mes1 required for meiotic progression in fission yeast. Dev Cell 2008;14(3):446-54

Mcdonald SAC, Greaves LC, Gutierrez-Gonzalez L, Rodriguez-Justo M, Deheragoda M, Leedham SJ, Taylor RW, Lee CY, Preston SL, Lovell M, Hunt T, Elia G, Oukrif D, Harrison R, Novelli MR, Mitchell I, Stoker DL, Turnbull DM, Jankowski JAZ, Wright NA. Mechanisms of field cancerization in the human stomach: The expansion and spread of mutated gastric stem cells. Gastroenterology 2008; 134(2):500-510

Ruiz EJ, Hunt T, Nebreda AR. Meiotic inactivation of Xenopus Myt1 by CDK/XRINGO, but not CDK/cyclin, via site-specific phosphorylation. Mol Cell 2008;32(2):210-20

Trenz K, Errico A, Costanzo V. Plx1 is required for chromosomal DNA replication under stressful conditions. EMBO J 2008;27(6):876-85

2007

Errico A, Costanzo V, Hunt T. Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts. Proc Natl Acad Sci U S A 2007; 104(38):14929-14934

Hochegger H, Deisuphong D, Sonoda E, Sciberi A, Rajendra E, Kirk J, Hunt T, Takeda S. An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells. J Cell Biol 2007; 178(2):257-268

Hunt T, Bergsten J, Levkanicova Z, Papadopoulou A, John OS, Wild R, Hammond PM, Ahrens D, Balke M, Caterino MS, Gomez-Zurita J, Ribera I, Barraclough TG, Bocakova M, Bocak L, Vogler AP. A comprehensive phylogeny of beetles reveals the evolutionary origins of a superradiation. Science 2007; 318(5858):1913-1916

Mochida S, Hunt T. Calcineurin is required to release Xenopus egg extracts from meiotic M phase. Nature 2007; 449(7160):336-+

Monaghan MT, Inward DJG, Hunt T, Vogler AP. A molecular phylogenetic analysis of the Scarabaeinae (dung beetles). Mol Phylogenet Evol 2007; 45(2):674-692

Petri ET, Errico A, Escobedo L, Hunt T, Basavappa R. The crystal structure of human cyclin B. Cell Cycle 2007; 6: 1342-1349.

2005

Casaletto JB, Nutt LK, Wu QJ, Moore JD, Etkin LD, Jackson PK, Hunt T, Kornbluth S. Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. J Cell Biol 2005; 169(1):61-71

Dinarina A, Perez LH, Davila A, Schwab M, Hunt T, Nebreda AR. Characterization of a new family of cyclin-dependent kinase activators. Biochem J 2005; 386(Pt 2):349-355

Esashi F, Christ N, Gannon J, Liu Y, Hunt T, Jasin M, West SC. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 2005; 434(7033):598-604

2004

Listovsky T, Oren YS, Yudkovsky Y, Mahbubani HM, Weiss AM, Lebendiker M, Brandeis M. Mammalian Cdh1/Fzr mediates its own degradation. EMBO J 2004; 23(7):1619-1626

Yamano H, Gannon J, Mahbubani H, Hunt T. Cell cycle-regulated recognition of the destruction box of cyclin B by the APC/C in Xenopus egg extracts. Mol Cell 2004; 13(1):137-147

Yamano H, Kominami K, Harrison C, Kitamura K, Katayama S, Dhut S, Hunt T, Toda T. Requirement of the SCFPop1/Pop2 ubiquitin ligase for degradation of the fission yeast S phase cyclin Cig2. J Biol Chem 2004; 279(18):18974-18980

2003

Christopoulou L, Moore JD, Tyler-Smith C. Over-expression of wild-type Securin leads to aneuploidy in human cells. Cancer Lett 2003; 202(2):213-218

Moore JD, Kirk JA, Hunt T. Unmasking the S-phase-promoting potential of cyclin B1. Science 2003; 300(5621):987-990

Sha W, Moore J, Chen K, Lassaletta AD, Yi CS, Tyson JJ, Sible JC. Hysteresis drives cell-cycle transitions in Xenopus laevis egg extracts. Proc Natl Acad Sci U S A 2003; 100(3):975-980

2002

Doree M, Hunt T. From Cdc2 to Cdk1: when did the cell cycle kinase join its cyclin partner? J Cell Sci 2002; 115(12):2461-2464

Graeser R, Gannon J, Poon RYC, Dubois T, Aitken A, Hunt T. Regulation of the CDK-related protein kinase PCTAIRE-1 and its possible role in neurite outgrowth in Neuro-2A cells. J Cell Sci 2002; 115(17):3479-3490

Hunt T. Protein synthesis, proteolysis, and cell cycle transitions. Biosci Rep 2002; 22(5-6):465-486

Moore JD, Kornbluth S, Hunt T. Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. Mol Biol Cell 2002; 13(12):4388-4400

Other Publications

p>Hochegger H,Takeda S, Hunt T. Cyclin-dependent kinases and cell-cycle transitions: does one fit all? Nat Rev Mol Cell Biol 2008;9(11):910-6

Hunt T. You never know: Cdk inhibitors as anti-cancer drugs. Cell Cycle 2008;7(24):3789-3790

Hunt T. European young investigators. Science 2007; 317(5846):1833-1833

Hunt T, Sassone-Corsi P. Riding tandem: Circadian clocks and the cell cycle. Cell 2007; 129(3):461-464

Krupa A, Srinivasan N. Diversity in domain architectures of Ser/Thr kinases andtheir homologues in prokaryotes. BMC Genomics 2005; 6:Article 129

Prigent C, Hunt T. Oocyte maturation and cell cycle control: a farewell symposium for Pr Marcel Doree. Biol Cell 2004; 96(3):181-185