Selected Publications
Massey A, Xu Y-Z and Karran P. Photoactivation of DNA thiobases as a potential novel therapeutic option. Curr Biol 2001; 11: 1142-1146. PubMed
Karran P, Offman J and Bignami M. Human mismatch repair, drug induced DNA damage and secondary cancer. Biochimie 2003; 85: 1149-1160. PubMed
Offman J, Opelz G, Doehler B, Cummins D, Halil O, Banner NR, Burke MM, Sullivan D, Macpherson P and Karran P. Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation. Blood 2004; 104: 822-828. PubMed
Primary Research Publications
2009
Brem R, Li F, Karran P. Reactive oxygen species generated by thiopurine/UVA cause irreparable transcription-blocking DNA lesions. Nucleic Acids Res. 2009 Feb 10.
Daehn I, Karran P. Immune effector cells produce lethal DNA damage in cells treated with a thiopurine. Cancer Res. 2009 Mar 15;69(6):2393-9.
2008
Harwood CA,Attard NR, OżDonovan P, Chambers P, Perrett CM, Proby CM, McGregor JM, Karran P. PTCH mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients. Br J Cancer 2008;99(8):1276-84
Perrett CM, Walker SL, OżDonovan P, Warwick J, Harwood CA, Karran P, McGregor JM. Azathioprine treatment photosensitizes human skin to ultraviolet A radiation. Br J Dermatol 2008;159(1):198-204
2007
Barone F, McCulloch SD, Macpherson P, Maga G, Yamada M, Nohmi T, Minoprio A, Mazzei F, Kunkel TA, Karran P, Bignami M. Replication of 2-hydroxyadenine-containing DNA and recognition by human MutS alpha. DNA Repair 2007; 6(3):355-366
Montaner B, O'Donovan P, Reelfs O, Perrett CM, Zhang X, Xu YZ, Ren X, Macpherson P, Frith D, Karran P. Reactive oxygen-mediated damage to a human DNA replication and repair protein. EMBO Rep 2007; 8(11):1074-1079
Perrett CM, McGregor JM, Warwick J, Karran P, Leigh IM, Proby CM, Harwood CA. Treatment of post-transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy. Br J Dermatol 2007; 156(2):320-328
Reelfs O, Xu YZ, Massey A, Karran P, Storey A. Thiothymidine plus low-dose UVA kills hyperproliferative human skin cells independently of their human papilloma virus status. Mol Cancer Ther 2007; 6(9):2487-2495
Zhang XH, Jeffs G, Ren XL, O'Donovan P, Montaner B, Perrett CM, Karran P, Xu YZ. Novel DNA lesions generated by the interaction between therapeutic thiopurines and UVA light. DNA Repair 2007; 6(3):344-354
2006
Karran P. Thiopurines, DNA damage, DNA repair and therapy-related cancer. Br Med Bull 2006; 79-80:153-170
2005
Barone F, Lankas F, Spackova N, Sponer J, Karran P, Bignami M, Mazzei F. Structural and dynamic effects of single 7-hydro-8-oxoguanine bases located in a frameshift target DNA sequence. Biophys Chem 2005; 118(1):31-41
Macpherson P, Barone F, Maga G, Mazzei F, Karran P, Bignami M. 8-Oxoguanine incorporation into DNA repeats in vitro and mismatch recognition by MutS alpha. Nucleic Acids Res 2005; 33(16):5094-5105
Oda S, Maehara Y, Ikeda Y, Oki E, Egashira A, Okamura Y, Takahashi I, Kakeji Y, Sumiyoshi Y, Miyashita K, Yamada Y, Zhao Y, Hattori H, Taguchi K, Ikeuchi T, Tsuzuki T, Sekiguchi M, Karran P, Yoshida MA. Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability. Nucleic Acids Res 2005; 33(5):1628-1636
O'Donovan P, Perrett CM, Zhang X, Montaner B, Xu Y-Z, Harwood CA, McGregor JM, Walker SL, Hanaoka F, Karran P. Azathioprine and UVA light generate mutagenic oxidative DNA damage. Science 2005; 309(5742):1871-1874
Offman J, Gascoigne K, Bristow F, Macpherson P, Bignami M, Casorelli I, Leone G, Pagano L, Sica S, Halil O, Cummins D, Banner NR, Karran P. Repeated sequences in CASPASE-5 and FANCD2 but not NF1 are targets for mutation in microsatellite-unstable acute leukemia/myelodysplastic syndrome. Mol Cancer Res 2005; 3(5):251-260
2004
Kobayashi K, O'Driscoll M, Macpherson P, Mullenders L, Vreeswijk M, Karran P. XPC lymphoblastoid cells defective in the hMutS alpha DNA mismatch repair complex exhibit normal sensitivity to UVC radiation and normal transcription-coupled excision repair of DNA cyclobutane pyrimidine dimers. DNA Repair 2004; 3(6):649-657
Offman J, Opelz G, Doehler B, Cummins D, Halil O, Banner NR, Burke MM, Sullivan D, Macpherson P, Karran P. Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation. Blood 2004; 104(3):822-828
Russo MT, Blasi MF, Chiera F, Fortini P, Degan P, Macpherson P, Furuichi M, Nakabeppu Y, Karran P, Aquilina G, Bignami M. The oxidized deoxynucleoside triphosphate pool is a significant contributor to genetic instability in mismatch repair-deficient cells. Mol Cell Biol 2004; 24(1):465-474
Xu Y-Z, Zhang X, Wu H-C, Massey A, Karran P. 4-Thio-5-bromo-2'-deoxyuridine: chemical synthesis and therapeutic potential of UVA-induced DNA damage. Bioorg Med Chem Lett 2004; 14(4):995-997
2003
Casorelli I, Offman J, Mele L, Pagano L, Sica S, D'Errico M, Giannini G, Leone G, Bignami M, Karran P. Drug treatment in the development of mismatch repair defective acute leukemia and myelodysplastic syndrome. DNA Repair 2003; 2(5):547-559
Durant S, Karran P. Vanillins - a novel family of DNA-PK inhibitors. Nucleic Acids Res 2003; 31(19):5501-5512
Karran P, Offman J, Bignami M. Human mismatch repair, drug-induced DNA damage, and secondary cancer. Biochimie 2003; 85(11):1149-1160
Massey A, Offman J, Macpherson P, Karran P. DNA mismatch repair and acquired cisplatin resistance in E-coli and human ovarian carcinoma cells. DNA Repair 2003; 2(1):73-89
2002
Colussi C, Parlanti E, Degan P, Aquilina G, Barnes D, Macpherson P, Karran P, Crescenzi M, Dogliotti E, Bignami M. The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool. Curr Biol 2002; 12(11):912-918
Massey A, Xu Y-Z, Karran P. Ambiguous coding is required for the lethal interaction between methylated DNA bases and DNA mismatch repair. DNA Repair 2002; 1(4):275-286
Parlanti E, Fortini P, Macpherson P, Laval J, Dogliotti E. Base excision repair of adenine/8-oxoguanine mispairs by an aphidicolin-sensitive DNA polymerase in human cell extracts. Oncogene 2002; 21(34):5204-5212
Other Publications
Karran P, Attard N. Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer. Nat Rev Cancer 2008;8(1):24-36
Perrett CM, McGregor J, Barlow RJ, Karran P, Proby C, Harwood CA. Topical photodynamic therapy with methyl aminolevulinate to treat sebaceous hyperplasia in an organ transplant recipient. Arch Dermatol 2006; 142(6):781-782
Bignami M, Casorelli I, Karran P. Mismatch repair and response to DNA-damaging antitumour therapies. Eur J Cancer 2003; 39(15):2142-2149
