Cancer Research UK Grants & Research: Banafshe Larijani

Selected Publications

Kong A, Leboucher P, Leek R, Calleja V, Winter S, Harris A, Parker PJ and Larijani B. Prognostic value of an activation state marker for epidermal growth factor receptor in tissue microarrays of head and neck cancer. Cancer Res 2006; 66: 2834-2843. PubMed

Barona T, Byrne RD, Pettitt TR, Wakelam MJO, Larijani B and Poccia DL. Diacylglycerol induces fusion of nuclear envelope membrane precursor vesicles. J Biol Chem 2005: 280: 41171-41177. PubMed

Byrne RD, Barona TM, Garnier M, Koster G, Katan M, Poccia DL and Larijani B. Nuclear envelope assembly is promoted by phosphoinositide-specific phospholipase C with selective recruitment of phosphatidylinositol-enriched membranes. Biochem J 2005; 387: 393-400. PubMed PDF (UKPMC)

Larijani B, Allen-Baume V, Morgan CP, Li M, Cockroft S. EGF regulation of PITP dynamics is blocked by inhibitors of phospholipase C and of the Ras-MAP kinase pathway. Current Biol 2003; 13: 78-84. PubMed

Calleja V, Ameer-Beg SM, Vojnovic B, Woscholski R, Downward J, Larijani B. Monitoring conformational changes of proteins in cells by fluorescence lifetime imaging microscopy. Biochem J 2003; 372: 33-40. PubMed PDF (UKPMC)

Primary Research Publications

2009

Alcor D, Calleja V, Larijani B. Revealing signaling in single cells by single- and two-photon fluorescence lifetime imaging microscopy. Methods Mol Biol. 2009; 462:307-43.

Byrne RD, Zhendre V, Larijani B, Poccia DL. Nuclear envelope formation in vitro: a sea urchin egg cell-free system. Methods Mol Biol. 2009; 464:207-23.

Byrne RD, Larijani B, Poccia DL. Tyrosine kinase regulation of nuclear envelope assembly. Adv Enzyme Regul. 2009 Jan 20

Calleja V, Laguerre M, Parker PJ, Larijani B. Role of a novel PH-kinase domain interface in PKB/Akt regulation: structural mechanism for allosteric inhibition. PLoS Biol. 2009; 7(1):e17.

Garnier-Lhomme M, Byrne RD, Hobday TM, Gschmeissner S, Woscholski R, Poccia DL, Dufourc EJ, Larijani B. Nuclear envelope remnants: fluid membranes enriched in Sterols and polyphosphoinositides. PLoS ONE. 2009;4(1):e4255.

Garnier-Lhomme M, Dufourc EJ, Larijani B, Poccia D. Lipid quantification and structure determination of nuclear envelope precursor membranes in the sea urchin. Methods Mol Biol. 2009;462:89-110.

Larijani B, Poccia DL. Nuclear envelope formation: mind the gaps. Annu Rev Biophys. 2009;38:107-24.

Poccia D, Larijani B. Phosphatidylinositol metabolism and membrane fusion. Biochem J. 2009 Mar 1;418(2):233-46.

2008

Guettler S,Vartiainen MK, Miralles F, Larijani B,Treisman R. RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding. Mol Cell Biol. 2008;28(2):732-42

Kong A, Calleja V, Leboucher P, Harris A, Parker PJ, Larijani B. HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells. PLoS ONE 2008;3(8):e2881

2007

Byrne RD, Garnier-Lhomme M, Han K, Dowicki M, Michael N, Totty N, Zhendre V, Cho A, Pettitt TR, Wakelam MJ, Poccia DL, Larijani B. PLC gamma is enriched on poly-phosphoinositide-rich vesicles to control nuclear envelope assembly. Cell Signal 2007; 19(5):913-922

Byrne RD, Rosivatz E, Parsons M, Larijani B, Parker PJ, Ng T, Woscholski R. Differential activation of the PI 3-kinase effectors AKT/PKB and p70 S6 kinase by compound 48/80 is mediated by PKCalpha. Cell Signal 2007; 19(2):321-329

Calleja V, Alcor D, Laguerre M, Park J, Vojnovic B, Hemmings BA, Downward J, Parker PJ, Larijani B. Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo. PLoS Biol 2007; 5(4):780-791

Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A, Laguerre M, Hemmings BA, McDonald N, Larijani B, Parker PJ. Protein kinases, from B to C. Biochem Soc Trans 2007; 35(Pt 5):1013-1017

Gamier-Lhomme M, Grelard A, Byrne RD, Loudet C, Dufourc EJ, Larijani B. Probing the dynamics of intact cells and nuclear envelope precursor membrane vesicles by deuterium solid state NMR spectroscopy. Biochim Biophys Acta [Biomembr] 2007; 1768(10):2516-2527

Vartiainen MK, Guettler S, Larijani B, Treisman R. Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL. Science 2007; 316(5832):1749-1752

2006

Ahyayauch H, Larijani B, Alonso A, Goni FM. Detergent solubilization of phosphatidylcholine bilayers in the fluid state: influence of the acyl chain structure. Biochim Biophys Acta [Biomembr] 2006; 1758(2):190-196

Fili N, Calleja V, Woscholski R, Parker PJ, Larijani B. Compartmental signal modulation: Endosomal phosphatidylinositol 3-phosphate controls endosome morphology and selective cargo sorting. Proc Natl Acad Sci U S A 2006; 103(42):15473-15478

Iturrioz X, Durgan J, Calleja V, Larijani B, Okuda H, Whelan R, Parker PJ. The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase C delta. Biochem J 2006; 397(Pt 1):109-120

Kakhlon O, Sakya P, Larijani B, Watson R, Tooze SA. GGA function is required for maturation of neuroendocrine secretory granules. EMBO J 2006; 25(8):1590-1602

Kong A, Leboucher P, Leek R, Calleja V, Winter S, Harris A, Parker PJ, Larijani B. Prognostic value of an activation state marker for epidermal growth factor receptor in tissue microarrays of head and neck cancer. Cancer Res 2006; 66(5):2834-2843

Larijani B, Dufourc EJ. Polyunsaturated phosphatidylinositol and diacylglycerol substantially modify the fluidity and polymorphism of biomembranes: A solid-state deuterium NMR study. Lipids 2006; 41(10):925-932

2005

Barona T, Byrne RD, Pettitt TR, Wakelam MJO, Larijani B, Poccia DL. Diacylglycerol induces fusion of nuclear envelope membrane precursor vesicles. J Biol Chem 2005; 280(50):41171-41177

Byrne RD, Barona TM, Garnier M, Koster G, Katan M, Poccia DL, Larijani B. Nuclear envelope assembly is promoted by phosphoinositide-specific phospholipase C with selective recruitment of phosphatidylinositol-enriched membranes. Biochem J 2005; 387(Pt 2):393-400

2004

Morgan CP, Skippen A, Segui B, Ball A, Allen-Baume V, Larijani B, Murray-Rust J, McDonald N, Sapkota G, Morrice N, Cockcroft S. Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser(166) by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes. J Biol Chem 2004; 279(45):47159-47171

2003

Larijani B, Allen-Baume V, Morgan CP, Li M, Cockcroft S. EGF regulation of PITP dynamics is blocked by inhibitors of phospholipase C and of the Ras-MAP kinase pathway. Curr Biol 2003; 13(1):78-84

Larijani B, Hume AN, Tarafder AK, Seabra MC. Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases. J Biol Chem 2003; 278(47):46798-46804

2002

Hughes WE, Larijani B, Parker PJ. Detecting protein-phospholipid interactions: epidermal growth factor-induced activation of phospholipase D1b in situ. J Biol Chem 2002; 277(25):22974-22979

Other Publications

Calleja V, Laguerre M, Larijani B. 3-D structure and dynamics of protein kinase B-new mechanism for the allosteric regulation of an AGC kinase. J Chem Biol 2009 Mar;2(1):11-25.

Byrne RD, Larijani B, and Poccia DL. Tyrosine kinase regulation of nuclear envelope assembly. Advances in Enzyme Regulation. 2008;Vol: 49

Byrne R, Larijani B. The role of phosphoinositides in mast cell signalling. Signal Transduct 2006; 6(2):81-91

Garnier M, Dufourc EJ, Larijani B. Characterisation of lipids in cell signalling and membrane dynamics by nuclear magnetic resonance spectroscopy and mass spectrometry. Signal Transduct 2006; 6(2):133-143

Woscholski R, Larijani B. Not just another journal. J Chem. Biol. 2008; 1(1-4):1-2