Cancer Research UK Grants & Research: Julian Lewis

Selected Publications

Gomez C, Ozbudak EM, Wunderlich J, Baumann D, Lewis J, Pourquié O. Control of segment number in vertebrate embryos. Nature 2008; 454: 335-339 PubMed

Giudicelli F, Ozbudak EM, Wright GJ, Lewis J. Setting the tempo in development: An investigation of the zebrafish somite clock mechanism. PLoS Biol 2007; 5: 1309-1323 PubMed

Leslie JD, Ariza-McNaughton L, Bermange AL, McAdow R, Johnson SL, Lewis J. Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis. Development 2007; 134: 839-844 PubMed

Brooker R, Hozumi K, Lewis J. Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development 2006; 133: 1277-1286 PubMed

Crosnier C, Stamataki D, Lewis J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet 2006; 7: 349-359 PubMed

Crosnier U, Vargesson N, Gschmeissner S, Ariza-McNaughton L, Morrison A, Lewis J. Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Development 2005; 132: 1093-1104 PubMed

Lewis J. Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator. Curr Biol 2003; 13: 1398-1408 PubMed

Primary Research Publications

2009

Daudet N, Gibson R, Shang J, Bernard A, Lewis J, Stone J. Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birds. Dev Biol. 2009 Feb 1;326(1):86-100.

Lewis J, Hanisch A, Holder M. Notch signaling, the segmentation clock, and the patterning of vertebrate somites. J Biol. 2009;8(4):44. Epub 2009 May 22.

2008

Daudet N, Gibson R, Shang J, Bernard A, Lewis J, Stone J. Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birds. Dev. Biol 2008;doi:10.1016/j.ydbio.2008.10.033

Gomez C, Ozbudak EM,Wunderlich J, Baumann D, Lewis J, Pourquié O. Control of segment number in vertebrate embryos. Nature 2008;454(7202):335-9

Ozbudak EM, Lewis J. Notch signalling synchronizes the zebrafish segmentation clock but is not needed to create somite boundaries. PLoS Genet 2008 Feb;4(2):e15

2007

Daudet N, Ariza-McNaughton L, Lewis J. Notch signalling is needed to maintain, but not to initiate, the formation of prosensory patches in the chick inner ear. Development 2007; 134(12):2369-2378

Duc Si Dong P, Munson CA, Norton W, Crosnier C, Pan X, Gong Z, Neumann CJ, Stainier DYR. Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nat Genet 2007; 39(3):397-402

Giudicelli F, Ozbudak EM, Wright GJ, Lewis J. Setting the tempo in development: An investigation of the zebrafish somite clock mechanism. PLoS Biol 2007; 5(6):1309-1323

Leslie JD, Ariza-McNaughton L, Bermange AL, McAdow R, Johnson SL, Lewis J. Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis. Development 2007; 134(5):839-844

2006

Brooker R, Hozumi K, Lewis J. Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development 2006; 133(7):1277-1286

2005

Daudet N, Lewis J. Two contrasting roles for Notch activity in chick inner ear development: specification of prosensory patches and lateral inhibition of hair-cell differentiation. Development 2005; 132(3):541-551

Davies A, Formstone C, Mason I, Lewis J. Planar polarity of hair cells in the chick inner ear is correlated with polarized distribution of c-Flamingo-1 protein. Dev Dyn 2005; 233(3):998-1005

Julich D, Lim CH, Round J, Nicolaije C, Schroeder J, Davies A, Geisler R, Lewis J, Jiang Y-J, Holley SA, Tubingen 2000 Screen Consortium. beamter/deltaC and the role of Notch ligands in the zebrafish somite segmentation, hindbrain neurogenesis and hypochord differentiation. Dev Biol 2005; 286(2):391-404

2004

Hirata H, Bessho Y, Kokubu H, Masamizu Y, Yamada S, Lewis J, Kageyama R. Instability of Hes7 protein is crucial for the somite segmentation clock. Nat Genet 2004; 36(7):750-754

Pasini A, Jiang Y-J, Wilkinson DG. Two zebrafish Notch-dependent hairy/Enhancer-of-split-related genes, her6 and her4, are required to maintain the coordination of cyclic gene expression in the presomitic mesoderm. Two zebrafish Notch-dependent hairy/Enhancer-of-split-related genes, her6 and her4, are required to maintain the coordination of cyclic gene expression in the presomitic mesoderm. Development 2004; 131(7):1529-1541

Qiu X, Xu H, Haddon C, Lewis J, Jiang Y-J. Sequence and embryonic expression of three zebrafish fringe genes: lunatic fringe, radical fringe, and manic fringe. Dev Dyn 2004; 231(3):621-630

Wright GJ, Leslie JD, Ariza-McNaughton L, Lewis J. Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development. Development 2004; 131(22):5659-5669

2003

Itoh M, Kim CH, Palardy G, Oda T, Jiang Y-J, Maust D, Yeo S-Y, Lorick K, Wright GJ, Ariza-McNaughton L, Weissman AM, Lewis J, Chandrasekharappa SC, Chitnis AB. Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta. Dev Cell 2003; 4(1):67-82

Le Roux I, Lewis J, Ish-Horowicz D. Notch activity is required to maintain floorplate identity and to control neurogenesis in the chick hindbrain and spinal cord. Int J Dev Biol 2003; 47(4):263-272

Lewis J. Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator. Curr Biol 2003; 13(16):1398-1408

Stevens CB, Davies AL, Battista S, Lewis JH, Fekete DM. Forced activation of Wnt signaling alters morphogenesis and sensory organ identity in the chicken inner ear. Dev Biol 2003; 261(1):149-164

Other Publications

Alberts B, Johnson A, Lewis J, Raff M, Roberts K, and Walter P. Molecular Biology of the Cell, 5th ed. 2008. New York: Garland.

Lewis J. From signals to patterns: space, time, and mathematics in developmental biology. Science 2008;322(5900):399-403

Lewis J, Ozbudak EM. Deciphering the somite segmentation clock: Beyond mutants and morphants. Dev Dyn 2007; 236(6):1410-1415

Crosnier C, Stamataki D, Lewis J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat Rev Genet 2006; 7(5):349-359

Giudicelli F, Lewis J. The vertebrate segmentation clock. Curr Opin Genet Dev 2004; 14(4):407-414

Alberts B, Bray D, Hopkin K, Johnson A, Lewis J, Raff M, Roberts K, and Walter P. Essential Cell Biology, 2nd ed. 2004. New York: Garland.

Lewis J, Davies A. Planar cell polarity in the inner ear: how do hair cells acquire their oriented structure? J Neurobiol 2002; 53(2):190-201

Alberts B, Johnson A, Lewis J, Raff M, Roberts K, and Walter P. Molecular Biology of the Cell, 4th ed. 2002 New York: Garland.