Selected Publications
Morita M, Stamp G, Robins P, Dulic A; Rosewell I, Hrivnak G, Daly G, Lindahl T and Barnes DE. Gene-targeted mice lacking the Trex1 (DNase III) 3'→5' DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol 2004; 24: 6719-6727. PubMed PDF (UKPMC)
Xie Y, Yang H, Cunanan C, Okamoto K, Shibata D, Pan J, Barnes DE, Lindahl T, McIlhatton M, Fishel R and Miller JH. Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. Cancer Res 2004; 64: 3096-3102. PubMed
Barnes DE and Lindahl T. Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annu Rev Genet 2004; 38: 445-476. PubMed
Koivisto P, Robins P, Lindahl T and Sedgwick B. Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases. J Biol Chem 2004; 279: 40470-40474. PubMed
Nilsen H, An Q and Lindahl T. Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient mice. Oncogene 2005; 24: 3063-3066. PubMed
An Q, Robins P, Lindahl T and Barnes DE. C→T mutagenesis and γ-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases. EMBO J 2005; 24: 2205-2213. PubMed PDF (UKPMC)
Paik J, Duncan T, Lindahl T and Sedgwick B. Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase. Cancer Res 2005; 65: 10472-10477. PubMed
Sedgwick B, Robins P and Lindahl T. Direct removal of alkylation damage from DNA by AlkB and related DNA dioxygenases. Meth Enzymol 2006; 408: 108-120. PubMed
Primary Research Publications
2009
Boissel S, Reish O, Proulx K, Kawagoe-Takaki H, Sedgwick B, Yeo GS, Meyre D, Golzio C, Molinari F, Kadhom N, Etchevers HC, Saudek V, Farooqi IS, Froguel P, Lindahl T, O'Rahilly S, Munnich A, Colleaux L. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet 2009 Jul;85(1):106-11
2008
Bleijlevens B, Shivarattan T, Flashman E,Yang Y, Simpson PJ, Koivisto P, Sedgwick B, Schofield CJ, Matthews SJ. Dynamic states of the DNA repair enzyme AlkB regulate product release. EMBO Rep 2008;9(9):872-7
2007
An Q, Robins P, Lindahl T, Barnes DE. 5-fluorouracil incorporated into DNA is excised by the Smug1 DNA glycosylase to reduce drug cytotoxicity. Cancer Res 2007; 67(3):940-945
Bleijlevens B, Shivarattan T, Sedgwick B, Rigby SEJ, Matthews SJ. Replacement of non-heme Fe(II) with Cu (II) in the alpha-ketoglutarate dependent DNA repair enzyme AlkB: Spectroscopic characterization of the active site. Journal of Inorganic Biochemistry 2007; 101: 1043-1048.
Gerken T, Girard CA, Tung YCL, Webby CJ, Saudek V, Hewitson KS, Yeo GSH, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318(5855):1469-1472
Rice G, Newman WG, Dean J, Patrick T, Parmar R, Flintoff K, Robins P, Harvey S, Hollis T, O'Hara A, Herrick AL, Bowden AP, Perrino FW, Lindahl T, Barnes DE, Crow YJ. Heterozygous mutations in TREX1 cause familial chilblain lupus and dominant Aicardi-Goutieres syndrome. Am J Hum Genet 2007; 80(4):811-815
Yang YG, Lindahl T, Barnes DE. Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. Cell 2007; 131(5):873-886
2006
Crow YJ, Hayward BE, Parmar R, Robins P, Leitch A, Ali M, Black DN, van Bokhoven H, Brunner HG, Hamel BC, Corry PC, Cowan FM, Frints SG, Klepper J, Livingston JH, Lynch SA, Massey RF, Meritet JF, Michaud JL, Ponsot G, Voit T, Lebon P, Bonthron DT, Jackson AP, Barnes DE, Lindahl T Mutations in the gene encoding the 3'-5' DNA exonuclease T REX1 cause Aicardi-Goutieres syndrome at the AGS1 locus. Nat Genet 2006; 38(8):917-920
2005
An Q, Robins P, Lindahl T, Barnes DE. C -> T mutagenesis and gamma-radiation sensitivity due to deficiency in the Smug1 and Ung DNA glycosylases. EMBO J 2005; 24(12):2205-2213
Andersen S, Heine T, Sneve R, Konig I, Krokan HE, Epe B, Nilsen H. Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis 2005; 26(3):547-555
Nilsen H, An Q, Lindahl T. Mutation frequencies and AID activation state in B-cell lymphomas from Ung-deficient mice. Oncogene 2005; 24(18):3063-3066
Paik J, Duncan T, Lindahl T, Sedgwick B. Sensitization of human carcinoma cells to alkylating agents by small interfering RNA suppression of 3-alkyladenine-DNA glycosylase. Cancer Res 2005; 65(22):10472-10477
2004
Barnes DE, Lindahl T. Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annu Rev Genet 2004; 38:445-476
Koivisto P, Robins P, Lindahl T, Sedgwick B. Demethylation of 3-methylthymine in DNA by bacterial and human DNA dioxygenases. J Biol Chem 2004; 279(39):40470-40474
Lindahl T. Inroads into base excision repair I: the discovery of apurinic/apyrimidinic (AP) endonuclease. DNA Repair 2004; 3(11):1521-1530
Morita M, Stamp G, Robins P, Dulic A, Rosewell I, Hrivnak G, Daly G, Lindahl T, Barnes DE. Gene-targeted mice lacking the Trex1 (DNase III) 3'->5' DNA exonuclease develop inflammatory myocarditis. Mol Cell Biol 2004; 24(15):6719-6727
Russo MT, De Luca G, Degan P, Parlanti E, Dogliotti E, Barnes DE, Lindahl T, Yang H, Miller JH, Bignami M. Accumulation of the oxidative base lesion 8-hydroxyguanine in DNA of tumor-prone mice defective in both the Myh and Ogg1 DNA glycosylases. Cancer Res 2004; 64(13):4411-4414
Xie YL, Yang HJ, Cunanan C, Okamoto K, Shibata D, Pan J, Barnes DE, Lindahl T, McIlhatton M, Fishel R, Miller JH. Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-Ras oncogene in lung tumors. Cancer Res 2004; 64(9):3096-3102
2003
Koivisto P, Duncan T, Lindahl T, Sedgwick B. Minimal methylated substrate and extended substrate range of Escherichia coli AlkB protein, a 1-methyladenine-DNA dioxygenase. J Biol Chem 2003; 278(45):44348-44354
Nilsen H, Stamp G, Andersen S, Hrivnak G, Krokan HE, Lindahl T, Barnes DE. Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas. Oncogene 2003; 22(35):5381-5386
Winter DB, Phung QH, Zeng XM, Seeberg E, Barnes DE, Lindahl T, Gearhart PJ. Normal somatic hypermutation 8-hydroxyguanine-DNA of Ig genes in the absence of glycosylase. J Immunol 2003; 170(11):5558-5562
2002
Colussi C, Parlanti E, Degan P, Aquilina G, Barnes D, Macpherson P, Karran P, Crescenzi M, Dogliotti E, Bignami M. The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool. Curr Biol 2002; 12(11):912-918
Duncan T, Trewick SC, Koivisto P, Bates PA, Lindahl T, Sedgwick B. Reversal of DNA alkylation damage by two human dioxygenases. Proc Natl Acad Sci U S A 2002; 99(26):16660-16665
Nilsen H, Lindahl T, Verreault A. DNA base excision repair of uracil residues in reconstituted nucleosome core particles. EMBO J 2002; 21(21):5943-5952
Rada C, Williams GT, Nilsen H, Barnes DE, Lindahl T, Neuberger MS. Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol 2002; 12(20):1748-1755
Sanderson RJ, Lindahl T. Down-regulation of DNA repair synthesis at DNA single-strand interruptions in poly(ADP-ribose) polymerase-1 deficient murine cell extracts. DNA Repair 2002; 1(7):547-558
Trewick SC, Henshaw TF, Hausinger RP, Lindahl T, Sedgwick B. Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature 2002; 419(6903):174-178
Other Publications
Lindahl T, Barnes DE, Yang YG, Robins P Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease. Biochem Soc Trans 2009 Jun;37(Pt 3):535-8
Sedgwick B, Bates PA, Paik J, Jacobs SC, Lindahl T. Repair of alkylated DNA: recent advances. DNA Repair 2007; 6(4):429-442
Friedberg EC, Aguilera A, Gellert M, Hanawalt PC, Hays JB, Lehmann AR, Lindahl T, Lowndes N, Sarasin A, Wood RD. DNA repair: From molecular mechanism to human disease. DNA Repair 2006; 5(8):986-996
Sedgwick B, Robins P, Lindahl T. Direct removal of alkylation damage from DNA by AlkB and related DNA dioxygenases. Methods Enzymol 2006; 408:108-120
Lindahl T. Dale Mosbaugh. DNA Repair 2005; 4(12):1346-1346
Shivarattan T, Chen HA, Simpson P, Sedgwick B, Matthews S. Resonance assignments of Escherichia coli AlkB: a key 2-oxoglutarate and Fe(II) dependent dioxygenase of the adaptive DNA-repair response. J Biomol NMR 2005; 33(2):138-138
Wood RD, Mitchell M, Lindahl T. Human DNA repair genes, 2005. Mutat Res Fundam Mol Mech Mutagen 2005; 577(1-2):275-283
Lindahl T. Molecular biology: ensuring error-free DNA repair. Nature 2004; 427(6975):598
Sedgwick B. Repairing DNA-methylation damage. Nat Rev Mol Cell Biol 2004; 5(2):148-157
Barnes DE. DNA damage: Air-breaks? Curr Biol 2002; 12(7):R262-R264
Sedgwick B, Lindahl T. Recent progress on the Ada response for inducible repair of DNA alkylation damage. Oncogene 2002; 21(58):8886-8894
