Structural Cancer Biology

The Structural Biology Laboratory uses X-ray crystallography with biophysical and biochemical methods to investigate the molecular function of proteins relevant to human cancer. Our current research covers two principle areas:

• establishing the molecular basis of specificity and regulation in cellular signalling pathways; and
• investigating the architecture and catalytic mechanism of endonucleases involved in the repair of intra- and inter-strand DNA crosslinks.

Both areas have direct relevance to understanding cancer and developing new cancer therapeutics.

Future projects
Future projects will investigate multi-protein complexes and assemblies containing protein kinases/protein phosphatases/endonucleases relevant to cancer.