Primary Research Publications
2009
Carlomagno F, Guida T, Anaganti S, Provitera L, Kjaer S, McDonald NQ, Ryan AJ, Santoro M. Identification of tyrosine 806 as a molecular determinant of RET kinase sensitivity to ZD6474. Endocr Relat Cancer. 2009 Mar;16(1):233-41. Epub 2008 Nov 24
Kostelecky B, Saurin AT, Purkiss A, Parker PJ, McDonald NQ Recognition of an intra-chain tandem 14-3-3 binding site within PKCvarepsilon. EMBO Rep 2009 Aug 7.
Roffey J, Rosse C, Linch M, Hibbert A, McDonald NQ, Parker PJ. Protein kinase C intervention-the state of play. Curr Opin Cell Biol. 2009 Feb 20. [Epub ahead of print]
2008
Ciccia A, McDonald N, West SC. Structural and functional relationships of the XPF/MUS81 family of protein. Annu Rev Biochem 2008;77:259-87
Kirk R, Laman H, Knowles PP, Murray-Rust J, Lomonosov M, Meziane el K, McDonald NQ. Structure of a conserved dimerization domain within the F-box protein Fbxo7 and the PI31 proteasome inhibitor. J Biol Chem 2008;283(32):22325-35
Mouilleron S, Guettler S, Langer CA,Treisman R, McDonald MQ. Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL. EMBO J 2008; 27(23):1-11
Roces L, Knowles PP, Fox G, Juanhuix J, Scaplehorn N, Way M, McDonald NQ. Crystallization and preliminary X-ray diffraction analysis of vaccinia virus H1L phosphatase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008;64(3):190-2
2007
Boeda B, Briggs DC, Higgins T, Garvalov BK, Fadden AJ, McDonald NQ, Way M. Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. Mol Cell 2007; 28(6):1071-1082
Cameron AJ, De Rycker M, Calleja V, Alcor D, Kjaer S, Kostelecky B, Saurin A, Faisal A, Laguerre M, Hemmings BA, McDonald N, Larijani B, Parker PJ. Protein kinases, from B to C. Biochem Soc Trans 2007; 35(Pt 5):1013-1017
Ciccia A, Ling C, Coulthard R, Yan ZJ, Xue YT, Meetei AR, Laghmani El H, Joenje H, McDonald N, de Winter JP, Wang WD, West SC. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell 2007; 25(3):331-343
Fox GC, Shafiq M, Briggs DC, Knowles PP, Collister M, Didmon MJ, Makrantoni V, Dickinson RJ, Hanrahan S, Totty N, Stark MJR, Keyse SM, McDonald NQ. Redox-mediated substrate recognition by Sdp1 defines a new group of tyrosine phosphatases. Nature 2007; 447(7143):487-492
Leiper J, Nandi M, Torondel B, Murray-Rust J, Malaki M, O'Hara B, Rossiter S, Anthony S, Madhani M, Selwood D, Smith C, Wojciak-Stothard B, Rudiger A, Stidwill R, McDonald NQ, Vallance P. Disruption of methylarginine metabolism impairs vascular homeostasis. Nat Med 2007; 13(2):198-203
Plun-Favreau H, Klupsch K, Moisoi N, Gandhi S, Kjaer S, Frith D, Harvey K, Deas E, Harvey RJ, McDonald N, Wood NW, Martins LM, Downward J. The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat Cell Biol 2007; 9(11):1243-1252
2006
Abou-Sleiman PM, Muqit MMK, McDonald NQ, Yang YX, Gandhi S, Healy DG, Harvey K, Harvey RJ, Deas E, Bhatia K, Quinn N, Lees A, Latchman DS, Wood NW. A heterozygous effect for PINK1 mutations in Parkinson's disease? Ann Neurol 2006; 60(4):414-419
Knowles PP, Murray-Rust J, Kjaer S, Scott RP, Hanrahan S, Santoro M, Ibanez CF, McDonald NQ. Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem 2006; 281(44):33577-33587
Rosivatz E, Matthews JG, McDonald NQ, Mulet X, Ho KK, Lossi N, Schmid AC, Mirabelli M, Pomeranz KM, Erneux C, Lam EWF, Vilar R, Woscholski R. A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem Biol 2006; 1(12):780-790
2005
Laman H, Funes JM, Ye HT, Henderson S, Galinanes-Garcia L, Hara E, Knowles P, McDonald N, Boshoff C. Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6. EMBO J 2005; 24(17):3104-3116
Newman M, Murray-Rust J, Lally J, Rudolf J, Fadden A, Knowles PP, White MF, McDonald NQ. Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition. EMBO J 2005; 24(5):895-905
Nicastro G, Menon RP, Masino L, Knowles PP, McDonald NQ, Pastore A. The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition. Proc Natl Acad Sci U S A 2005; 102(30):10493-10498
2004
Lally J, Newman M, Murray-Rust J, Fadden A, Kawarabayasi Y, McDonald N. Crystallization of the xeroderma pigmentosum group F endonuclease from Aeropyrum pernix. Acta Crystallogr D 2004; 60(Pt 9):1658-1661
Lehmann A, Katayama S, Harrison C, Dhut S, Kitamura K, McDonald N, Toda T. Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint. Genes Cells 2004; 9(5):367-382
Morgan CP, Skippen A, Segui B, Ball A, Allen-Baume V, Larijani B, Murray-Rust J, McDonald N, Sapkota G, Morrice N, Cockcroft S. Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser(166) by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes. J Biol Chem 2004; 279(45):47159-47171
Movahedzadeh F, Smith DA, Norman RA, Dinadayala P, Murray-Rust J, Russell DG, Kendall SL, Rison SCG, McAlister MSB, Bancroft GJ, McDonald NQ, Daffe M, Av-Gay Y, Stoker NG. The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence. Mol Microbiol 2004; 51(4):1003-1014
Tilley SJ, Skippen A, Murray-Rust J, Swigart PM, Stewart A, Morgan CP, Cockcroft S, McDonald NQ. Structure-function analysis of phosphatidylinositol transfer protein alpha bound to human phosphatidylinositol. Structure (Camb) 2004; 12(2):317-326
2002
Collister M, Didmon MP, MacIsaac F, Stark MJ, MacDonald NQ, Keyse SM. YIL113w encodes a functional dual-specificity protein phosphatase which specifically interacts with and inactivates the Slt2/Mpk1p MAP kinase in S-cerevisiae. FEBS Lett 2002; 527(1-3):186-192
Hornig NCD, Knowles PP, McDonald NQ, Uhlmann F. The dual mechanism of separase regulation by securin. Curr Biol 2002; 12(12):973-982
Leiper J, Murray-Rust J, McDonald NQ, Vallance P. S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proc Natl Acad Sci U S A 2002; 99(21):13527-13532
Norman RA, McAlister MSB, Murray-Rust J, Movahedzadeh F, Stoker NG, McDonald NQ. Crystal structure of inositol 1-phosphate synthase from Mycobacterium tuberculosis, a key enzyme in phosphatidylinositol synthesis. Structure (Camb) 2002; 10(3):393-402
Other Publications
Parker PJ, Murray-Rust J. PKC at a glance. J Cell Sci 2004; 117(2):131-132
