Selected Publications
Nurse P. A long twentieth century of the cell cycle and beyond. Cell 2000; 100: 71-78. PubMed
Watanabe Y, Yokobayashi S, Yamamoto M and Nurse P. Pre-meiotic S phase is linked to reductional chromosome segregation and recombination. Nature 2001; 409: 359-363. PubMed
Wuarin J, Buck V, Nurse P and Millar JBA. Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication. Cell 2002; 111; 419-431. PubMed
Murakami H, Yanow SK, Griffiths D, Nakanishi M and Nurse P. Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p. Nature Cell Biol 2002; 4: 384-388. PubMed
Wood V, Gwilliam R, Rajandream M-A, Lyne M, ......... and Nurse P. The genome sequence of Schizosaccharomyces pombe. Nature 2002; 415: 871-880. PubMed
Pardo M and Nurse P. Equatorial retention of the contractile actin ring by microtubules during cytokinesis. Science 2003; 300: 1569-1574. PubMed
Primary Research Publications
2009
Deshpande GP, Hayles J, Hoe KL, Kim DU, Park HO, Hartsuiker E Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance. DNA Repair (Amst). 2009 May 1;8(5):672-9. Epub 2009 Mar 4.
Dodgson J, Avula H, Hoe KL, Kim DU, Park HO, Hayles J, Armstrong J Functional genomics of adhesion, invasion, and mycelial formation in Schizosaccharomyces pombe. Eukaryot Cell 2009 Aug;8(8):1298-306
2008
Dixon SJ, Fedyshyn Y, Koh JL, Prasad TS, Chahwan C, Chua G,Toufighi K, Baryshnikova A, Hayles J, Hoe KL, Kim DU, Park HO, Myers CL, Pandey A, Durocher D,Andrews BJ, Boone C. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proc Natl Acad Sci U S A 2008;105(43):16653-8
Jansson K, Warringer J, Farewell A, Park HO, Hoe KL, Kim DU, Hayles J, Sunnerhagen P. The tumor suppressor homolog in fission yeast, myh1(+), displays a strong interaction with the checkpoint gene rad1(+). Mutat Res 2008;644(1-2):48-55
Kennedy PJ, Vashisht AA, Hoe KL, Kim DU, Park HO, Hayles J, Russell P. A genome-wide screen of genes involved in cadmium tolerance in Schizosaccharomyces pombe. Toxicol Sci 2008;106(1):124-39
Lygeros J, Koutroumpas K, Dimopoulos S, Legouras I, Kouretas P, Heichinger C, Nurse P, and Lygerou Z. Stochastic hybrid modeling of DNA replication across a complete genome. Proc Natl Acad Sci USA. 2008;105(34):12295-300
Roguev A, Bandyopadhyay S, Zofall M, Zhang K, Fischer T, Collins SR, Qu H, Shales M, Park HO, Hayles J, Hoe KL, Kim DU, Ideker T, Grewal SI, Weissman JS, Krogan NJ. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Science 2008;322(5900):405-10
Zuin A, Gabrielli N, Calvo IA, García-Santamarina S, Hoe KL, Kim DU, Park HO, Hayles J,Ayté J, Hidalgo E. Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast. PLoS ONE 2008;3(7):e2842
2007
Castagnetti S, Novak B, Nurse P. Microtubules offset growth site from the cell centre in fission yeast. J Cell Sci 2007; 120(13):2205-2213
Fersht N, Hermand D, Hayles J, Nurse P. Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast. Nucleic Acids Res 2007; 35(16):5323-5337
Hermand D, Nurse P. Cdc18 enforces long-term maintenance of the S phase checkpoint by anchoring the Rad3-Rad26 complex to chromatin. Mol Cell 2007; 26(4):553-563
Neumann FR, Nurse P. Nuclear size control in fission yeast. J Cell Biol 2007; 179(4):593-600
Petersen J, Nurse P. TOR signalling regulates mitotic commitment through the stress MAP kinase pathway and the Polo and Cdc2 kinases. Nat Cell Biol 2007; 9(11):1263-U97
2006
Carazo-Salas RE, Nurse P. Self-organization of interphase microtubule arrays in fission yeast. Nat Cell Biol 2006; 8(10):1102-1107
Heichinger C, Penkett CJ, Bahler J, Nurse P. Genome-wide characterization of fission yeast DNA replication origins. EMBO J 2006; 25(21):5171-5179
2005
Carazo-Salas RE, Antony C, Nurse P. The kinesin Klp2 mediates polarization of interphase microtubules in fission yeast. Science 2005; 309(5732):297-300
Castagnetti S, Behrens R, Nurse P. End4/Sla2 is involved in establishment of a new growth zone in Schizosaccharomyces pombe. J Cell Sci 2005; 118(9):1843-1850
Leonhard K, Nurse P. Ste20/GCK kinase Nak1/Orb3 polarizes the actin cytoskeleton in fission yeast during the cell cycle. J Cell Sci 2005; 118(5):1033-1044
Malapeira J, Moldon A, Hidalgo E, Smith GR, Nurse P, Ayte J. A meiosis-specific cyclin regulated by splicing is required for proper progression through meiosis. Mol Cell Biol 2005; 25(15):6330-6337
Pardo M, Nurse P. The nuclear rim protein Amo1 is required for proper microtubule cytoskeleton organisation in fission yeast. J Cell Sci 2005; 118(8):1705-1714
2004
Busch KE, Hayles J, Nurse P, Brunner D. Tea2p kinesin is involved in spatial microtubule organization by transporting Tip1p on microtubules. Dev Cell 2004; 6(6):831-843
Niccoli T, Yamashita A, Nurse P, Yamamoto M. The p150-glued Ssm4p regulates microtubular dynamics and nuclear movement in fission yeast. J Cell Sci 2004; 117(23):5543-5556
Rustici G, Mata J, Kivinen K, Lio P, Penkett CJ, Burns G, Hayles J, Brazma A, Nurse P, Bahler J. Periodic gene expression program of the fission yeast cell cycle. Nat Genet 2004; 36(8):809-817
Sugimoto I, Murakami H, Tonami Y, Moriyama A, Nakanishi M. DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeast. J Biol Chem 2004; 279(45):47372-47378
Xouri G, Lygerou Z, Nishitani H, Pachnis V, Nurse P, Taraviras S. Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines. Eur J Biochem 2004; 271(16):3368-3378
2003
Browning H, Hackney DD, Nurse P. Targeted movement of cell end factors in fission yeast. Nat Cell Biol 2003; 5(9):812-818
Castagnetti S, Ephrussi A. Orb and a long poly(A) tall are required for efficient oskar translation at the posterior pole of the Drosophila oocyte. Development 2003; 130(5):835-843
Decottignies A, Sanchez-Perez I, Nurse P. Schizosaccharomyces pombe essential genes: a pilot study. Genome Res 2003; 13(3):399-406
Drewes G, Nurse P. The protein kinase kin1, the fission yeast orthologue of mammalian MARK/PAR-1, localises to new cell ends after mitosis and is important for bipolar growth. FEBS Lett 2003; 554(1-2):45-49
Espeli O, Nurse P, Levine C, Lee C, Marians KJ. SetB: an integral membrane protein that affects chromosome segregation in Escherichia coli. Mol Microbiol 2003; 50(2):495-509
Hermand D, Bamps S, Tafforeau L, Vandenhaute J, Makela TP. Skp1 and the F-box protein Pof6 are essential for cell separation in fission yeast. J Biol Chem 2003; 278(11):9671-9677
Niccoli T, Arellano M, Nurse P. Role of Tea1p, Tea3p and Pom1p in the determination of cell ends in Schizosaccharomyces pombe. Yeast 2003; 20(16):1349-1358
Nurse P, Levine C, Hassing H, Marians KJ. Topoisomerase III can serve as the cellular decatenase in Escherichia coli. J Biol Chem 2003; 278(10):8653-8660
Pardo M, Nurse P. Equatorial retention of the contractile actin ring by microtubules during cytokinesis. Science 2003; 300(5625):1569-1574
Yamaguchi S, Decottignies A, Nurse P. Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint. EMBO J 2003; 22(5):1075-1087
2002
Arellano M, Niccoli T, Nurse P. Tea3p is a cell end marker activating polarized growth in Schizosaccharomyces pombe. Curr Biol 2002; 12(9):751-756
Behrens R, Nurse P. Roles of fission yeast tea1p in the localization of polarity factors and in organizing the microtubular cytoskeleton. J Cell Biol 2002; 157(5):783-793
Borgne A, Murakami H, Ayte J, Nurse P. The G1/S cyclin Cig2p during meiosis in fission yeast. Mol Biol Cell 2002; 13(6):2080-2090
Carazo-Salas RE, Brunet S. Division spindle assembly: the secret lies in the chromosomes. MS Med Sci 2002; 18(12):1219-1226
Murakami H, Yanow SK, Griffiths D, Nakanishi M, Nurse P. Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1p. Nat Cell Biol 2002; 4(5):384-388
Niccoli T, Nurse P. Different mechanisms of cell polarisation in vegetative and shmooing growth in fission yeast. J Cell Sci 2002; 115(8):1651-1662
Nurse PM. Cyclin dependent kinases and cell cycle control. Biosci Rep 2002; 22(5-6):487-499
Wood V, Gwilliam R, Rajandream M-A, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Schafer M, Muller-Auer S, Gabel C, Fuchs M, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dreano S, et_al ...Nurse P The genome sequence of Schizosaccharomyces pombe. Nature 2002; 415(6874):871-880
Wuarin J, Buck V, Nurse P, Millar JBA. Stable association of mitotic cyclin B/Cdc2 to replication origins prevents endoreduplication. Cell 2002; 111(3):419-431
Zarzov P, Decottignies A, Baldacci G, Nurse P. G(1)/S CDK is inhibited to restrain mitotic onset when DNA replication is blocked in fission yeast. EMBO J 2002; 21(13):3370-3376
Other Publications
Carazo-Salas R, Nurse P. Sorting out interphase microtubules. Mol Syst Biol 2007; 3:Article 95
Mandelbrot B, Horvitz E, Nurse P. What comes after homo sapiens? James Hughes. New Sci 2006; 192(2578):70-72
Nurse P. US biomedical research under siege. Cell 2006; 124(1):9-12
Hagan I, Nurse P. Nobel microbes define the art of cell division. Microbiol Today 2005; 32:122-126
Nurse P. Wee beasties. Nature 2004; 432(7017):557-557
Nurse P. The great ideas of biology. Clin Med 2003; 3(6):560-568
Nurse P. Understanding cells. Nature 2003; 424(6951):883-883
Nurse P, Pattison J, Radda G, O'Toole L. Cancer research: joint planning for the future. Ann Oncol 2003; 14(11):1593-1594
O'Toole L, Nurse P, Radda G. An analysis of cancer research funding in the UK. Nat Rev Cancer 2003; 3(2):139-143
Nurse P. Cyclin dependent kinases and cell cycle control (Nobel lecture). Chembiochem 2002; 3(7):596-+
