Selected Publications
Llanos S, Clark PA, Rowe J and Peters G. Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus. Nature Cell Biol 2001; 3: 445-452. PubMed
Brookes S, Rowe J, Ruas M, Llanos S, Clark PA, Lomax M, James MC, Vatcheva R, Bates S, Vousden KH, Parry D, Gruis N, Smit N, Bergman W and Peters G. INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J 2002; 21: 2936-2945. PubMed PDF (UKPMC)
Drayton S, Rowe J, Jones R, Vatcheva R, Cuthbert-Heavens D, Marshall J, Fried M and Peters G. Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes. Cancer Cell 2003; 4: 301-310. PubMed
Brookes S, Rowe J, Gutierrez del Arroyo A, Bond J and Peters G. Contribution of p16INK4a to replicative senescence of human fibroblasts. Exp Cell Res 2004; 298: 549-559. PubMed
Kim S-H, Rowe J, Fujii H, Jones R, Schmierer B, Kong B-W, Kichler K, Foster D, Ish-Horowicz d and Peters G. Upregulation of chicken p15INK4b at senescence and in the developing brain. J Cell Sci 2006; 119: 2345-2443. PubMed
Primary Research Publications
2009
Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenf¿hr M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS Genes Dev. 2009 May 15;23(10):1177-82.
Irelan JT, Gutierrez Del Arroyo A, Gutierrez A, Peters G, Quon KC, Miraglia L, Chanda SK. A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a. PLoS ONE. 2009;4(4):e5067. Epub 2009 Apr 2
Kannengiesser C, Brookes S, del Arroyo AG, Pham D, Bombled J, Barrois M, Mauffret O, Avril MF, Chompret A, Lenoir GM, Sarasin A; French Hereditary Melanoma Study Group, Peters G, Bressac-de Paillerets B. Functional, structural, and genetic evaluation of 20 CDKN2A germ line mutations identified in melanoma-prone families or patients. Hum Mutat. 2009 Apr;30(4):564-74
Wolyniec K, Wotton S, Kilbey A, Jenkins A, Terry A, Peters G, Stocking C, Cameron E, Neil JC. RUNX1 and its fusion oncoprotein derivative, RUNX1-ETO, induce senescence-like growth arrest independently of replicative stress. Oncogene. 2009 May 18. [Epub ahead of print]
2008
Leontiou CA, Gueorguiev M, van der Spuy J, Quinton R, Lolli F, Hassan S, Chahal HS, Igreja SC, Jordan S, Rowe J, Stolbrink M, Christian HC, Wray J, Bishop-Bailey D, Berney DM, Wass JA, Popovic V, Ribeiro-Oliveira A Jr, Gadelha MR, Monson JP,Akker SA, Davis JR, Clayton RN,Yoshimoto K, Iwata T, Matsuno A, Eguchi K, Musat M, Flanagan D, Peters G, Bolger GB, Chapple JP, Frohman LA, Grossman AB, Korbonits M. The role of the aryl hydrocarbon receptorinteracting protein gene in familial and sporadic pituitary adenomas. J Clin Endocrinol Metab 2008;93(6):2390-401
Moulin S, Llanos S, Kim SH, Peters G. Binding to nucleophosmin determines the localization of human and chicken ARF but not its impact on p53. Oncogene 2008;27(17):2382-9
2007
del Arroyo AG, El Messaoudi S, Clark PA, James M, Stott F, Bracken A, Helin K, Peters G. E2F-dependent induction of p14ARF during cell cycle re-entry in human T cells. Cell Cycle 2007; 6(21):2697-2705
Elderkin S, Maertens GN, Endoh M, Mallery DL, Morrice N, Koseki H, Peters G, Brockdorff N, Hiom K. A phosphorylated form of mel-18 targets the Ring1B histone H2A ubliquitin ligase to chromatin. Mol Cell 2007; 28(1):107-120
Jones R, Ruas M, Gregory F, Moulin S, Delia D, Manoukian S, Rowe J, Brookes S, Peters G. A CDKN2A mutation in familial melanoma that abrogates binding of p16(INK4a) to CDK4 but not CDK6. Cancer Res 2007; 67(19):9134-9141
Ruas M, Gregory F, Jones R, Poolman R, Starborg M, Rowe J, Brookes S, Peters G. CDK4 and CDK6 delay senescence by kinase-dependent and p16(INK4a)-lndependent mechanisms. Mol Cell Biol 2007; 27(12):4273-4282
Scott CL, Gil J, Hernando E, Teruya-Feldstein J, Narita M, Martinez D, Visakorpi T, Mu D, Cordon-Cardo C, Peters G, Beach D, Lowe SW. Role of the chromobox protein CBX7 in lymphomagenesis. Proc Natl Acad Sci U S A 2007; 104(13):5389-5394
2006
Jarviluoma A, Child ES, Sarek G, Sirimongkolkasem P, Peters G, Ojala PM, Mann DJ. Phosphorylation of the cyclin-dependent kinase inhibitor p21(Cip1) on serine 130 is essential for viral cyclin-mediated bypass of a p21(Cip1)-imposed G(1) arrest. Mol Cell Biol 2006; 26(6):2430-2440
Kim S-H, Rowe J, Fujii H, Jones R, Schmierer B, Kong BW, Kuchler K, Foster D, Ish-Horowicz D, Peters G. Upregulation of chicken p15(INK4b) at senescence and in the developing brain. J Cell Sci 2006; 119(12):2435-2443
Laud K, Marian C, Avril MF, Barrois M, Chompret A, Goldstein AM, Tucker MA, Clark PA, Peters G, Chaudru V, Demenais F, Spatz A, Smith MW, Lenoir GM, Bressac-de Paillerets B, French Hereditary Melanoma Study Group. Comprehensive analysis of CDKN2A (p16(INK4A)/p14(ARF)) and CDKN2B genes in 53 melanoma index cases considered to be at heightened risk of melanoma. J Med Genet 2006; 43(1):39-47
Zannetti C, Mondini M, De Andrea M, Caposio P, Hara E, Peters G, Gribaudo G, Gariglio M, Landolfo S. The expression of p161(INK4a) tumor suppressor is upregulated by human cytomegalovirus infection and required for optimal viral replication. Virology 2006; 349(1):79-86
2005
Bernard D, Martinez-Leal JF, Rizzo S, Martinez D, Hudson D, Visakorpi T, Peters G, Carnero A, Beach D, Gil J. CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus. Oncogene 2005; 24(36):5543-5551
Gil J, Kerai P, Lleonart M, Bernard D, Cigudosa JC, Peters G, Carnero A, Beach D. Immortalization of primary human prostate epithelial cells by c-Myc. Cancer Res 2005; 65(6):2179-2185
Kondoh H, Lleonart ME, Gil J, Wang J, Degan P, Peters G, Martinez D, Carnero A, Beach D. Glycolytic enzymes can modulate cellular life span. Cancer Res 2005; 65(1):177-185
Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC. Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Mol Cell 2005; 20(5):673-685
2004
Brooke S, Rowe J, Gutierrez del Arroyo A, Bond J, Peters G. Contribution of p16(INK4a) to replicative senescence of human fibroblasts. Exp Cell Res 2004; 298(2):549-559
Drayton S, Brookes S, Rowe J, Peters G. The significance of p16(INK4a) in cell defenses against transformation. Cell Cycle 2004; 3(5):611-615
Gil J, Bernard D, Martinez D, Beach D. Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol 2004; 6(1):67-72
Hayes MJ, Koundouris A, Gruis N, Bergman W, Peters GG, Sinclair AJ. P16(INK4A)-independence of Epstein-Barr virus-induced cell proliferation and virus latency. J Gen Virol 2004; 85(Pt 6):1381-1386
Rodway H, Llanos S, Rowe J, Peters G. Stability of nucleolar versus non-nucleolar forms of human p14(ARF). Oncogene 2004; 23(37):6186-6192
2003
Drayton S, Rowe J, Jones R, Vatcheva R, Cuthbert-Heaven D, Marshall J, Fried M, Peters G. Tumor suppressor p16(INK4a) determines sensitivity of human cells to transformation by cooperating cellular oncogenes. Cancer Cell 2003; 4(4):301-310
Kim S-H, Mitchell M, Fujii H, Llanos S, Peters G. Absence of p16(INK4a) and truncation of ARF tumor suppressors in chickens. Proc Natl Acad Sci U S A 2003; 100(1):211-216
Peters G, Brookes S, Rowe J. Using p16INK4a deficient human fibroblasts to study cellular senescence. Exp Med 2003; 21(6):769-774
Sviderskaya EV, Gray-Schopfer VC, Hill SP, Smit NP, Evans-Whipp TJ, Bond J, Hill L, Bataille V, Peters G, Kipling D, Wynford-Thomas D, Bennett DC. p16/cyclin-dependent kinase inhibitor 2A deficiency in human melanocyte senescence, apoptosis, and immortalization: possible implications for melanoma progression. J Natl Cancer Inst 2003; 95(10):723-732
Yakobson E, Eisenberg S, Isacson R, Halle D, Levy-Lahad E, Catane R, Safro M, Sobolev V, Huot T, Peters G, Ruiz A, Malvehy J, Puig S, Chompret A, Avril M-F, Shafir R, Peretz H, Bressac-de Paillerets B. A single Mediterranean, possibly Jewish, origin for the Val59Gly CDKN2A mutation in four melanomaprone families. Eur J Hum Genet 2003; 11(4):288-296
2002
Brookes S, Rowe J, Ruas M, Llanos S, Clark PA, Lomax M, James MC, Vatcheva R, Bates S, Vousden KH, Parry D, Gruis N, Smit N, Bergman W, Peters G. INK4a-deficient human diploid fibroblasts are resistant to RAS-induced senescence. EMBO J 2002; 21(12):2936-2945
Clark PA, Llanos S, Peters G. Multiple interacting domains contribute to p14(ARF) mediated inhibition of MDM2. Oncogene 2002; 21(29):4498-4507
Coverley D, Laman H, Laskey RA. Distinct roles for cyclins E and A during DNA replication complex assembly and activation. Nat Cell Biol 2002; 4(7):523-528
Huot TJ, Rowe J, Harland M, Drayton S, Brookes S, Gooptu C, Purkis P, Fried M, Bataille V, Hara E, Newton Bishop J, Peters G. Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts. Mol Cell Biol 2002; 22(23):8135-8143
Sugimoto M, Martin N, Wilks DP, Tamai K, Huot TJG, Pantoja C, Okumura K, Serrano M, Hara E. Activation of cyclin DI-kinase in murine fibroblasts lacking both p21(Cip1) and P27(Kip1). Oncogene 2002; 21(53):8067-8074
Other Publications
Peters G. An INKlination for epigenetic control of senescence. Nat Struct Mol Biol 2008;15(11):1133-4
Peters G. Tumor suppression for ARFicionados: the relative contributions of p16INK4a and p14ARF in melanoma. J Natl Cancer Inst 2008;100(11):757-9
Gil J, Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol 2006; 7(9):667-677
Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, Benguria A, Zaballos A, Flores JM, Barbacid M, Beach D, Serrano M. Tumour biology - Senescence in premalignant tumours. Nature 2005; 436(7051):642-642
Gil J, Bernard D, Peters G. Role of polycomb group proteins in stem cell self-renewal and cancer. DNA Cell Biol 2005; 24(2):117-125
Gutierrez del Arroyo A, Peters G. The INK4A/ARF network: cell cycle checkpoint or emergency brake? Adv Exp Med Biol 2005; 570:227-247
Kondoh H, Lleonart ME, Gil J, Beach D, Peters G. Glycolysis and cellular immortalization. Drug Discov Today Dis Mech 2005; 2(2):263-267
Gil J, Esteban M. Vaccinia virus recombinants as a model system to analyze interferon-induced pathways. J Interferon Cytokine Res 2004; 24(11):637-646
Drayton S, Peters G. Immortalisation and transformation revisited. Curr Opin Genet Dev 2002; 12(1):98-104
