Selected Publications
Wyckoff JB, Pinner SE, Gschmeissner S, Condeelis JS and Sahai E. ROCK and myosin dependent matrix deformation enables protease independent tumour cell invasion in vivo. Curr Biology 2006, 16: 1515-1523. PubMed
Goswami S, Sahai E, Wyckoff JB, Cammer M, Cox D, Pixley FJ, Stanley ER, Segall JE and Condeelis JS. Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/ epidermal growth factor paracrine loop. Cancer Res 2005; 65: 5278-5283. PubMed
Sahai E. Mechanisms of cancer cell invasion. Curr Opinion Genet Dev 2005; 15: 87-96. PubMed
Sahai E and Marshall CJ. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nature Cell Biology 2003; 5: 711-719. PubMed
Sahai E and Marshall CJ. Rho GTPases and cancer. Nature Reviews Cancer 2002; 2: 133-142. PubMed
Primary Research Publications
2009
Medjkane S, Perez-Sanchez C, Gaggioli C, Sahai E, Treisman R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol. 2009 Mar;11(3):257-68. Epub 2009 Feb 8
Grusche FA, Hidalgo C, Fletcher G, Sung HH, Sahai E, Thompson BJ. Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]. BMC Dev Biol. 2009 Feb 19;9:14
2008
Philippar U, Roussos ET, Oser M, Yamaguchi H, Kim HD, Giampieri S, Wang Y, Goswami S, Wyckoff JB, Lauffenburger DA, Sahai E, Condeelis JS, Gertler FB. A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell 2008;15(6):813-28
Pinner S, Sahai E. PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE. Nat Cell Biol 2008;10(2):127-37
Sanz-Moreno V, Gadea G, Ahn J, Paterson H, Marra P, Pinner S, Sahai E, Marshall CJ. Rac activation and inactivation control plasticity of tumor cell movement. Cell 2008;135(3):510-23
2007
Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E. Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells. Nat Cell Biol 2007; 9(12):1392-U92
Macpherson IR, Hooper S, Serrels A, McGarry L, Ozanne BW, Harrington K, Frame MC, Sahai E, Brunton VG. p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism. Oncogene 2007; 26(36):5214-5228
Sahai E, Garcia-Medina R, Pouyssegur J, Vial E. Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. J Cell Biol 2007; 176(1):35-42
Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, Elustondo F, Chang J, Temple J, Ahmed AA, Brenton JD, Downward J, Nicke B. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell 2007; 11(6):498-512
2006
Wyckoff JB, Pinner SE, Gschmeissner S, Condeelis JS, Sahai E. ROCK- and myosin-dependent matrix deformation enables protease-independent tumor-cell invasion in vivo. Curr Biol 2006; 16(15):1515-1523
Xue C, Wyckoff J, Liang F, Sidani M, Violini S, Tsai K-L, Zhang Z-Y, Sahai E, Condeelis J, Segall JE. Epidermal growth factor receptor overexpression results in increased tumor cell motility in vivo coordinately with enhanced intravasation and metastasis. Cancer Res 2006; 66(1):192-197
2005
Brockbank EC, Bridges J, Marshall CJ, Sahai E. Integrin beta 1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo. Br J Cancer 2005; 92(1):102-112
Goswami S, Sahai E, Wyckoff JB, Cammer N, Cox D, Pixley FJ, Stanley ER, Segall JE, Condeelis JS. Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res 2005; 65(12):5278-5283
Pixley FJ, Xiong Y, Yu RY-L, Sahai EA, Stanley ER, Ye BH. BCL6 suppresses RhoA activity to alter macrophage morphology and motility. J Cell Sci 2005; 118(9):1873-1883
Sahai E, Wyckoff J, Philippar U, Segall JE, Gertler F, Condeelis J. Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy. BMC Biotechnol 2005; 5:Article 14
2004
Croft DR, Sahai E, Mavria G, Li SX, Tsai J, Lee WMF, Marshall CJ, Olson MF. Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis. Cancer Res 2004; 64(24):8994-9001
Wang WG, Goswami S, Lapidus K, Wells AL, Wyckoff JB, Sahai E, Singer RH, Segall JE, Condeelis JS. Identification and testing of a gene expression signature of invasive carcinoma cells within primary mammary tumors. Cancer Res 2004; 64(23):8585-8594
Other Publications
Olson MF, Sahai E. The actin cytoskeleton in cancer cell motility. Clin Exp Metastasis. 2008;10.1007/s10585-008-9174-2
Pinner S, Sahai E. Imaging amoeboid cancer cell motility in vivo. J Microsc 2008;231(3):441-5
Gaggioli C, Sahai E. Melanoma invasion - current knowledge and future directions. Pigment Cell Res 2007; 20(3):161-172
Sahai E. Illuminating the metastatic process. Nat Rev Cancer 2007; 7(10):737-749
Hooper S, Marshall JF, Sahai E. Tumor cell migration in three dimensions. Methods Enzymol 2006; 406:625-643
Sahai E, Olson MF. Purification of TAT-C3 exoenzyme. Methods Enzymol 2006; 406:128-140
Sahai E. Mechanisms of cancer cell invasion. Curr Opin Genet Dev 2005; 15(1):87-96
Wang WG, Goswami S, Sahai E, Wyckoff JB, Segall JE, Condeelis JS. Tumor cells caught in the act of invading: their strategy for enhanced cell motility. Trends Cell Biol 2005; 15(3):138-145
