Selected Publications

Hammond GRV, Dove SK, Nicol A, Pinxteren JA, Zicha D and Schiavo G. Elimination of plasma membrane phosphatidylinositol(4,5)-bisphosphate is required for exocytosis from mast cells. J Cell Sci 2006, 119: 2084-2094. PubMed

Rigoni M, Caccin P, Gschmeissner S, Koster G, Postle AD, Rossetto O, Schiavo G and Montecucco C. Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures. Science 2005; 310: 1678-1680. PubMed

Bohnert S and Schiavo G. Tetanus toxin is transported in a novel neuronal compartment characterized by a specialized pH regulation. J Biol Chem 2005; 280: 42336-42344. PubMed

Meunier FA, Osborne SL, Hammond GRV, Cooke FT, Parker PJ, Domin J and Schiavo G. Phosphatidylinositol 3-kinase C2α is essential for ATP-dependent priming of neurosecretory granule exocytosis. Mol Biol Cell 2005; 16: 4841-4851. PubMed PDF (UKPMC)

Kieran D, Hafezparast M, Bohnert S, Dick JRT, Martin J, Schiavo G, Fisher EMC and Greensmith L. A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice. J Cell Biol 2005; 169: 561-567. PubMed

Primary Research Publications

2009

Caleo M, Schiavo G. Central effects of tetanus and botulinum neurotoxins. Toxicon. 2009 Mar 3

Granata A, Schiavo G, Warner TT. TorsinA and dystonia: from nuclear envelope to synapse J Neurochem. 2009 Apr 8. [Epub ahead of print]

Hammond GR, Schiavo G, Irvine RF Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2). Biochem J 2009 Jul 29;422(1):23-35

Ohka S, Sakai M, Bohnert S, Igarashi H, Deinhardt K, Schiavo G, Nomoto A. Receptor-dependent and -independent axonal retrograde transport of poliovirus in motor neurons. J Virol. 2009 Feb 25.

Pichlmair A, Schulz O, Tan CP, Rehwinkel J, Kato H, Takeuchi O, Akira S, Way M, Schiavo G, Reis E Sousa C. Activation of MDA5 requires higher order RNA structures generated during virus infection. J Virol 2009 Aug 5.

Rinaldi S, Brennan KM, Goodyear CS, O'Leary C, Schiavo G, Crocker PR, Willison HJ. Analysis of lectin binding to glycolipid complexes using combinatorial glycoarrays. Glycobiology. 2009 Jul;19(7):789-96. Epub 2009 Apr 6

Salinas S, Bilsland LG, Henaff D, Weston AE, Keriel A, Schiavo G, Kremer EJ CAR-associated vesicular transport of an adenovirus in motor neuron axons. PLoS Pathog. 2009 May;5(5):e1000442. Epub 2009 May 22.

Vilar M, Charalampopoulos I, Kenchappa RS, Simi A, Karaca E, Reversi A, Choi S, Bothwell M, Mingarro I, Friedman WJ, Schiavo G, Bastiaens PI, Verveer PJ, Carter BD, Ib ¤ez CF. Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron. 2009 Apr 16;62(1):72-83.

2008

Fasano C, Campana V, Griffiths B, Kelly G, Schiavo G, Zurzolo C. Gene expression profile of quinacrine-cured prion-infected mouse neuronal cells. J Neurochem 2008;105(1):239-50

Granata A,Watson R, Collinson LM, Schiavo G, Warner TT. The dystonia-associated protein torsinA modulates synaptic vesicle recycling J Biol Chem 2008;283(12):7568-79

Semerdjieva S, Shortt B, Maxwell E, Sukhdeep S, Fonarev P, Hansen J, Schiavo G, Grant BD and Smythe E. Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6. J Cell Biol 183, 499-511

2007

Bowen S, Ateh DD, Deinhardt K, Bird MM, Price KM, Baker CS, Robson JC, Swash M, Shamsuddin W, Kawar S, El-Tawil T, Roos J, Hoyle A, Nickols CD, Knowles CH, Pullen AH, Luthert PJ, Weller RO, Hafezparast M, Franklin RJM, Revesz T, King RHM, Berninghausen O, Fisher EMC, Schiavo G, Martin JE The phagocytic capacity of neurones. Eur J Neurosci 2007; 25(10):2947-2955

Bracale A, Cesca F, Neubrand VE, Newsome TP, Way M, Schiavo G. Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation. Mol Biol Cell 2007; 18(1):142-152

Deinhardt K, Reversi A, Berninghausen O, Hopkins CR, Schiavo G. Neurotrophins redirect p75(NTR) from a clathrin-independent to a clathrin-dependent endocytic pathway coupled to axonal transport. Traffic 2007; 8(12):1736-1749

Kasperaviciute D, Weale ME, Shianna KV, Banks GT, Simpson CL, Hansen VK, Turner MR, Shaw CE, Al-Chalabi A, Pall HS, Goodall EF, Morrison KE, Orrell RW, Beck M, Jablonka S, Sendtner M, Brockington A, Ince PG, Hartley J, Nixon H, Shaw PJ, Schiavo G, Wood NW, Goldstein DB, Fisher EMC Large-scale pathways-based association study in amyotrophic lateral sclerosis. Brain 2007; 130(Pt 9):2292-2301

Magnani E, Fan J, Gasparini L, Golding M, Williams M, Schiavo G, Goedert M, Amos LA, Spillantini MG. Interaction of tau protein with the dynactin complex. EMBO J 2007; 26(21):4546-4554

Rigoni M, Pizzo P, Schiavo G, Weston AE, Zatti G, Caccin P, Rossetto O, Pozzan T, Montecucco C. Calcium influx and mitochondrial alterations at synapses exposed to snake neurotoxins or their phospholipid hydrolysis products. J Biol Chem 2007; 282(15):11238-11245

Salinas S, Carazo-Salas RE, Proukakis C, Schiavo G, Warner TT. Spastin and microtubules: Functions in health and disease. J Neurosci Res 2007; 85(12):2778-2782

2006

Deinhardt K, Berninghausen O, Willison HJ, Hopkins CR, Schiavo G. Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. J Cell Biol 2006; 174(3):459-471

Deinhardt K, Salinas S, Verastegui C, Watson R, Worth D, Hanrahan S, Bucci C, Schiavo G. Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway. Neuron 2006; 52(2):293-305

Hammond GRV, Dove SK, Nicol A, Pinxteren JA, Zicha D, Schiavo G. Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells. J Cell Sci 2006; 119(10):2084-2094

Ioannidou S, Deinhardt K, Miotla J, Bradley J, Cheung E, Samuelsson S, Ng Y-S, Shima DT. An in vitro assay reveals a role for the diaphragm protein PV-1 in endothelial fenestra morphogenesis. Proc Natl Acad Sci U S A 2006; 103(45):16770-16775

Schenning M, Proctor DT, Ragnarsson L, Barbier J, Lavidis NA, Molgo JJ, Zamponi GW, Schiavo G, Meunier FA. Glycerotoxin stimulates neurotransmitter release from N-type Ca2+ channel expressing neurons. J Neurochem 2006; 98(3):894-904

2005

Achilli F, Boyle S, Kieran D, Chia R, Hafezparast M, Martin JE, Schiavo G, Greensmith L, Bickmore W, Fisher EMC. The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12. Amyotroph Lateral Scler Other Motor Neuron Disord 2005; 6(2):111-114

Bohnert S, Schiavo G. Tetanus toxin is transported in a novel neuronal compartment characterized by a specialized pH regulation. J Biol Chem 2005; 280(51):42336-42344

Kieran D, Hafezparast M, Bohnert S, Dick JRT, Martin J, Schiavo G, Fisher EMC, Greensmith L. A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice. J Cell Biol 2005; 169(4):561-567

Meunier FA, Osborne SL, Hammond GRV, Cooke FT, Parker PJ, Domin J, Schiavo G. Phosphatidylinositol 3-kinase C2 alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis. Mol Biol Cell 2005; 16(10):4841-4851

Misbahuddin A, Placzek MR, Taanman J-W, Gschmeissner S, Schiavo G, Cooper JM, Warner TT. Mutant torsinA, which causes early-onset primary torsion dystonia, is redistributed to membranous structures enriched in vesicular monoamine transporter in cultured human SH-SY5Y cells. Mov Disord 2005; 20(4):432-440

Parsons M, Monypenny J, Ameer-Beg SM, Millard TH, Machesky LM, Peter M, Keppler MD, Schiavo G, Watson R, Chernoff J, Zicha D, Vojnovic B, Ng T. Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Mol Cell Biol 2005; 25(5):1680-1695

Rigoni M, Caccin P, Gschmeissner S, Koster G, Postle AD, Rossetto O, Schiavo G, Montecucco C. Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures. Science 2005; 310(5754):1678-1680

Salinas S, Carazo-Salas RE, Proukakis C, Cooper JM, Weston AE, Schiavo G, Warner TT. Human spastin has multiple microtubule-related functions. J Neurochem 2005; 95(5):1411-1420

2004

Golding M, Ruhrberg R, Sandle J, Gullick WJ. Mapping nucleolar and spliceosome localization sequences of neuregulin1-beta 3. Exp Cell Res 2004; 299(1):110-118

Hammond G, Thomas CL, Schiavo G. Nuclear phosphoinositides and their functions. Curr Top Microbiol Immunol 2004; 282:177-206

Rigoni M, Schiavo G, Weston AE, Caccin P, Allegrini F, Pennuto M, Valtorta F, Montecucco C, Rossetto O. Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles. J Cell Sci 2004; 117(16):3561-3570

Usui T, Isbida S, Yamasbiro K, Kaji Y, Poulaki V, Moore J, Shima DT, Adamis AP. VEGF(164(165)) as the pathological isoform: differential leukocyte and endothelial responses through VEGFR1 and VEGFR2. Invest Ophthalmol Vis Sci 2004; 45(2):368-374

2003

Caccin P, Rossetto O, Rigoni M, Johnson E, Schiavo G, Montecucco C. VAMP/synaptobrevin cleavage by tetanus and botulinum neurotoxins is strongly enhanced by acidic liposomes. FEBS Lett 2003; 542(1-3):132-136

Hafezparast M, Klocke R, Ruhrberg C, Marquardt A, Ahmad-Annuar A, Bowen S, Lalli G, Witherden AS, Hummerich H, Nicholson S, Morgan PJ, Oozageer R, Priestley JV, Averill S, King VR, Ball S, Peters J, Toda T, Yamamoto A, Hiraoka Y, Augustin M, Korthaus D, Wattler S, Wabnitz P, Dickneite C, Lampel S, Boehme F, Peraus G, Popp A, Rudelius M, Schlegel J, Fuchs H, de Angelis MH, Schiavo G, Shima DT, Russ AP, Stumm G, Martin JE, Fisher EMC Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science 2003; 300(5620):808-812

Jimenez JL, Smith GR, Contreras-Moreira B, Sgouros JG, Meunier FA, Bates PA, Schiavo G. Functional recycling of C2 domains throughout evolution: a comparative study of synaptotagmin, protein kinase C and phospholipase C by sequence, structural and modelling approaches. J Mol Biol 2003; 333(3):621-639

Lalli G, Gschmeissner S, Schiavo G. Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons. J Cell Sci 2003; 116(22):4639-4650

Lesa GM, Palfreyman M, Hall DH, Clandinin MT, Rudolph C, Jorgensen EM, Schiavo G. Long chain polyunsaturated fatty acids are required for efficient neurotransmission in C-elegans. J Cell Sci 2003; 116(24):4965-4975

2002

Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ. Purification and characterization of the human Elongator complex. J Biol Chem 2002; 277(4):3047-3052

Herreros J, Schiavo G. Lipid microdomains are involved in neurospecific binding and internalisation of clostridial neurotoxins. Int J Med Microbiol 2002; 291(6-7):447-453

Lalli G, Schiavo G. Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75(NTR). J Cell Biol 2002; 156(2):233-239

Meunier FA, Feng Z-P, Molgo J, Zamponi GW, Schiavo G. Glycerotoxin from Glycera convoluta stimulates neurosecretion by up-regulating N-type Ca2+ channel activity. EMBO J 2002; 21(24):6733-6743

Meunier FA, Schiavo G, Molgo J. Botulinum neurotoxins: from paralysis to recovery of functional neuromuscular transmission. J Physiol (Paris) 2002; 96(1-2):105-113

Other Publications

Bilsland LG and Schiavo G. Axonal transport tracers. The New Encyclopedia of Neuroscience. Academic Press, Oxford (UK). 2008;1209-1216

Salinas S, Bilsland LG, Schiavo G. Molecular landmarks along the axonal route: axonal transport in health and disease. Curr Opin Cell Biol 2008;20(4):445-53

Tooze SA, Schiavo G. Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration. Curr Opin Neurobiol 2008;18(5):504-15

Hammond GRV, Schiavo G. Polyphosphoinositol lipids: Under-PPInning synaptic functio n in health and disease. Dev Neurobiol 2007; 67(9):1232-1247

Salinas S, Carazo-Salas RE, Proukakis C, Schiavo G, Warner TT. Spastin and microtubules: functions in health and disease. J Neurosci Res 2007; :

Schiavo G. Dangerous liaisons on neurons. Nature 2006; 444(7122):1019-1020

Deinhardt K, Schiavo G. Endocytosis and retrograde axonal traffic in motor neurons. Biochem Soc Symp 2005; 72:139-150

Montecucco C, Schiavo G, Pantano S. SNARE complexes and neuroexocytosis: how many, how close? Trends Biochem Sci 2005; 30(7):367-372

Montecucco C, Rossetto O, Schiavo G. Presynaptic receptor arrays for clostridial neurotoxins. Trends Microbiol 2004; 12(10):442-446

Schiavo G, Chao MV. Motors, adaptors, and receptors: key elements of neuronal transport. J Neurobiol 2004; 58(2):161-163

Lalli G, Bohnert S, Deinhardt K, Verastegui C, Schiavo G. The journey of tetanus and botulinum neurotoxins in neurons. Trends Microbiol 2003; 11(9):431-437

Verastegui C, Lalli G, Bohnert S, Meunier FA, Schiavo G. Clostridial neurotoxins. J Toxicol Toxin Rev 2002; 21(3):203-227