Selected Publications

Porstmann, T., Santos, C.R, Griffiths, B., Cully, M., Wu, M. Leevers, S. Griffiths, J.R., Chung, Y.-l. and Schulze A. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metabolism 2008, 8(3): 224-236.PubMed Full text

Delpuech O, Griffiths B, East P, Essafi A, Lam EWF, Burgering B, Downward J, Schulze A. Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Mol Cell Biol 2007; 27(13):4917-4930.PubMed Full text

Porstmann T, Griffiths B, Chung Y-L, Delpeuch O, Griffiths JR, Downward J and Schulze A. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 2005, doi:10.1038/sj.onc.1208802. PubMed

Schulze A and Downward J. Navigating gene expression using microarrays: a technology review. Nature Cell Biol. 2001; 3: E190-195. PubMed

Schulze A, Lehmann K, Jefferies HB, McMahon M and Downward J. Analysis of the transcriptional program induced by Raf in epithelial cells. Genes Dev. 2001; 15: 981-994. PubMed Full text

Primary Research Publications

2009

Porstmann T, Santos CR, Lewis C, Griffiths B, Schulze A. A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size. Biochem Soc Trans. 2009 Feb;37(Pt 1):278-83

2008

Hui RC, Gomes AR, Constantinidou D, Costa JR, Karadedou CT, Fernandez de Mattos S,Wymann MP, Brosens JJ, Schulze A, Lam EW. The forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Mol Cell Biol 2008;28(19):5886-98

Porstmann T, Santos CR, Griffiths B, Cully M,Wu M, Leevers S, Griffiths JR, Chung YL, Schulze A. SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 2008;8(3):224-36

2007

Delpuech O, Griffiths B, East P, Essafi A, Lam EWF, Burgering B, Downward J, Schulze A. Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression. Mol Cell Biol 2007; 27(13):4917-4930

2005

Nicke B, Bastien J, Khanna SJ, Warne PH, Cowling V, Cook SJ, Peters G, Delpuech O, Schulze A, Berns K, Mullenders J, Beijersbergen RL, Bernards R, Ganesan TS, Downward J, Hancock DC. Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Mol Cell 2005; 20(5):673-685

Porstmann T, Griffiths B, Chung Y-L, Delpuech O, Griffiths JR, Downward J, Schulze A. PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 2005; 24(43):6465-6481

van den Heuvel APJ, Schulze A, Burgering BMT. Direct control of caveolin-1 expression by FOXO transcription factors. Biochem J 2005; 385(Pt 3):795-802

2004

Schulze A, Nicke B, Warne PH, Tomlinson S, Downward J. The transcriptional response to Raf activation is almost completely dependent on mitogen-activated protein kinase kinase activity and shows a major autocrine component. Mol Biol Cell 2004; 15(7):3450-3463