Selected Publications
Kvint K, Uhler JP, Taschner M, Sigurdsson S, Erdjument-Bromage H, Tempst P, and Svejstrup JQ. Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3. Molecular Cell 2008; 30: 498-506. PubMed
Anindya R, Aygün O, and Svejstrup JQ. Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne Syndrome proteins or BRCA1. Molecular Cell 2007; 28: 386-397. PubMed
Somesh BP, Sigurdsson S, Saeki H, Erdjument-Bromage H, Tempst P, and Svejstrup JQ. Communication between distant sites in RNA polymerase II through ubiquitylation factors and the polymerase CTD. Cell 2007; 129: 57-68. PubMed
Somesh BP, Reid J, Liu W-F, Søgaard TMM, Erdjument-Bromage H, Tempst P and Svejstrup JQ. Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest. Cell 2005; 121: 913-923. PubMed
Gilbert C, Kristjuhan A, Winkler GB and Svejstrup JQ. Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation. Mol Cell 2004; 14: 457-464. PubMed
Primary Research Publications
2009
Aygün O, Xu X, Liu Y, Takahashi H, Kong SE, Conaway RC, Conaway JW, Svejstrup JQ. Direct Inhibition of RNA Polymerase II Transcription by RECQL5. J Biol Chem 2009 Aug 28;284(35):23197-203.
Greenwood C, Selth LA, Dirac-Svejstrup AB, Svejstrup JQ. An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator. J Biol Chem. 2009 Jan 2;284(1):141-9. Epub 2008 Nov 5.
Saeki H, Svejstrup JQ. Stability, flexibility, and dynamic interactions of colliding RNA polymerase II elongation complexes. Mol Cell 2009 Jul 31;35(2):191-205
Selth LA, Lorch Y, Ocampo-Hafalla MT, Mitter R, Shales M, Krogan NJ, Kornberg RD, Svejstrup JQ An Rtt109-independent role for Vps75 in transcription-associated nucleosome dynamics. Mol Cell Biol. 2009 May 26.
2008
Aygün O, Svejstrup JQ, Liu Y. A RECQ5-RNA polymerase II association identified by targeted proteomic analysis of human chromatin. Proc Natl Acad Sci U S A 2008;105(25):8580-4
Greenwood C, Selth LA, Dirac-Svejstrup AB, Svejstrup JQ. An iron-sulfur cluster domain in ELP3 important for the structural integrity of elongator. J Biol Chem 2008;doi:10.1074/jbc.M805312200
Kvint K, Uhler JP,Taschner MJ, Sigurdsson S, Erdjument- Bromage H,Tempst P, Svejstrup JQ. Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease Ubp3. Mol Cell 2008;30(4):498-506
2007
Anindya R, Aygun O, Svejstrup JQ. Damage-induced ubiquitylation of human RNA polymerase II by the ubiquitin ligase Nedd4, but not Cockayne syndrome proteins or BRCA1. Mol Cell 2007; 28(3):386-397
Selth L, Svejstrup JQ. Vps75, a new yeast member of the NAP histone chaperone family. J Biol Chem 2007; 282(17):12358-12362
Sogaard TMM, Svejstrup JQ. Hyperphosphorylation of the C-terminal repeat domain of RNA polymerase II facilitates dissociation of its complex with mediator. J Biol Chem 2007; 282(19):14113-14120
Somesh BP, Sigurdsson S, Saeki H, Erdjument-Bromage H, Tempst P, Svejstrup JQ. Communication between distant sites in RNA polymerase II through ubiquitylation factors and the polymerase CTD. Cell 2007; 129(1):57-68
Svejstrup JQ. Elongator complex: how many roles does it play? Curr Opin Cell Biol 2007; 19(3):331-336
Uhler JP, Herteit C, Svejstrup JQ. A role for noncoding transcription in activation of the yeast PH05 gene. Proc Natl Acad Sci U S A 2007; 104(19):8011-8016
2006
Close P, Hawkes N, Cornez I, Creppe C, Lambert CA, Rogister B, Siebenlist U, Merville M-P, Slaugenhaupt SA, Bours V, Svejstrup JQ, Chariot A. Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia. Mol Cell 2006; 22(4):521-531
2005
Kong SE, Kobor MS, Krogan NJ, Somesh BP, Sogaard TMM, Greenblatt JF, Svejstrup JQ. Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with Elongator. J Biol Chem 2005; 280(6):4299-4306
Petrakis TG, Sogaard TMM, Erdjument-Bromage H, Tempst P, Svejstrup JQ. Physical and functional interaction between Elongator and the chromatin-associated Kti12 protein. J Biol Chem 2005; 280(20):19454-19460
Somesh BP, Reid J, Liu W-F, Sogaard TMM, Erdjument-Bromage H, Tempst P, Svejstrup JQ. Multiple mechanisms confining RNA polymerase II ubiquitylation to polymerases undergoing transcriptional arrest. Cell 2005; 121(6):913-923
2004
Gilbert C, Kristjuhan A, Winkler GS, Svejstrup JQ. Elongator interactions with nascent mRNA revealed by RNA immunoprecipitation. Mol Cell 2004; 14(4):457-464
Kristjuhan A, Svejstrup JQ. Evidence for distinct mechanisms facilitating transcript elongation through chromatin in vivo. EMBO J 2004; 23(21):4243-4252
Petrakis TG, Wittschieben BO, Svejstrup JQ. Molecular architecture, structure-function relationship, and importance of the Elp3 subunit for the RNA binding of holo-elongator. J Biol Chem 2004; 279(31):32087-32092
Reid J, Svejstrup JQ. DNA damage-induced Def1-RNA polymerase II interaction and Def1 requirement for polymerase ubiquitylation in vitro. J Biol Chem 2004; 279(29):29875-29878
2003
Kristjuhan A, Wittschieben BO, Walker J, Roberts D, Cairns BR, Svejstrup JQ. Spreading of Sir3 protein in cells with severe histone H3 hypoacetylation. Proc Natl Acad Sci U S A 2003; 100(13):7551-7556
2002
Creton S, Svejstrup JQ, Collart MA. The NC2 alpha and beta subunits play different roles in vivo. Genes Dev 2002; 16(24):3265-3276
Hawkes NA, Otero G, Winkler GS, Marshall N, Dahmus ME, Krappmann D, Scheidereit C, Thomas CL, Schiavo G, Erdjument-Bromage H, Tempst P, Svejstrup JQ. Purification and characterization of the human Elongator complex. J Biol Chem 2002; 277(4):3047-3052
Kong SE, Svejstrup JQ. Incision of a 1,3-intrastrand d(GpTpG)-cisplatin adduct by nucleotide excision repair proteins from yeast. DNA Repair 2002; 1(9):731-741
Kristjuhan A, Walker J, Suka N, Grunstein M, Roberts D, Cairns BR, Svejstrup JQ. Transcriptional inhibition of genes with severe histone H3 hypoacetylation in the coding region. Mol Cell 2002; 10(4):925-933
Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G. Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115. J Cell Biol 2002; 157(1):45-62
Winkler GS, Kristjuhan A, Erdjument-Bromage H, Tempst P, Svejstrup JQ. Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc Natl Acad Sci U S A 2002; 99(6):3517-3522
Winkler GS, Lacomis L, Philip J, Erdjument-Bromage H, Svejstrup JQ, Tempst P. Isolation and mass spectrometry of transcription factor complexes. Methods 2002; 26(3):260-269
Woudstra EC, Gilbert C, Fellows J, Jansen L, Brouwer J, Erdjument-Bromage H, Tempst P, Svejstrup JQ. A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage. Nature 2002; 415(6874):929-933
Other Publications
Svejstrup JQ. Contending with transcriptional arrest during RNAPII transcript elongation. Trends Biochem Sci 2007; 32(4):165-171
Reid J, Svejstrup JQ. An assay for studying ubiquitylation of RNA polymerase II and other proteins in crude yeast extracts. Methods Enzymol 2006; 408:264-273
Svejstrup JQ, Conaway RC, Conaway JW. RNA polymerase II: a "Nobel" enzyme demystified. Mol Cell 2006; 24(5):637-642
Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim YJ, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD A unified nomenclature for protein subunits of Mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 2004; 14(5):553-557
Svejstrup JQ. The RNA polymerase II transcription cycle: cycling through chromatin. Biochim Biophys Acta [Gene Struct Express] 2004; 1677(1-3):64-73
Svejstrup J. Keeping RNA and DNA apart during transcription. Mol Cell 2003; 12(3):538-539
Svejstrup JQ. Rescue of arrested RNA polymerase II complexes. J Cell Sci 2003; 116(3):447-451
Svejstrup JQ. Transcription: histones face the FACT. Science 2003; 301(5636):1053-1055
Svejstrup JQ, Petrakis TG, Fellows J. Purification of elongating RNA polymerase II and other factors from yeast chromatin. Methods Enzymol 2003; 371:491-498
Svejstrup JQ. Chromatin elongation factors. Curr Opin Genet Dev 2002; 12(2):156-161
Svejstrup JQ. How ATP-dependent chromatin remodelers work. Trends Biochem Sci 2002; 27(10):501-502
Svejstrup JQ. Mechanisms of transcription-coupled DNA repair. Nat Rev Mol Cell Biol 2002; 3(1):21-29
Svejstrup JQ. Transcription repair coupling factor: a very pushy enzyme. Mol Cell 2002; 9(6):1151-1152
