Selected Publications

Swanton C, Tomlinson I, Downward J. Chromosomal instability, colorectal cancer and taxane resistance. Cell Cycle 2006, 5(8):818-823. PubMed

Swanton C, Marani M, Pardo O, Warne PH, Kelly G, Sahai E, Elustondo F, Chang J, Temple J, Ahmed AA et al. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell 2007, 11(6):498-512. PubMed

Swanton C, Nicke B, Marani M, Kelly G, Downward J. Initiation of high frequency multi-drug resistance following kinase targeting by siRNAs. Cell Cycle 2007, 6(16):2001-2004. PubMed

Ahmed A, Mills A, Ibrhahim A, Temple J, Blenkiron C, Vias M, Massie C, Lyer G, McGeoch A, Crawford R et al. The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. Cancer Cell 2007, 12(6):514-527. PubMed

Harrison M, Swanton C. Epothilones and new analogues of the microtubule modulators in taxane-resistant disease. Expert Opin Investig Drugs 2008, 17(4):523-546. PubMed

Primary Research Publications

2009

Lee AJ, Kolesnick R, Swanton C. RNAi-mediated functional analysis of pathways influencing cancer cell drug resistance. Expert Rev Mol Med. 2009 May 21;11:e15.

Swanton C, Nicke B, Schuett M, Eklund AC, Ng C, Li Q, Hardcastle T, Lee A, Roy R, East P, Kschischo M, Endesfelder D, Wylie P, Kim SN, Chen JG, Howell M, Ried T, Habermann JK, Auer G, Brenton JD, Szallasi Z, Downward J. Chromosomal instability determines taxane response. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8671-6.

Swanton C, Caldas C. Molecular classification of solid tumours: towards pathway-driven therapeutics. Br J Cancer. 2009 May 19;100(10):1517-22. Epub 2009 Apr 14.

Walther A, Johnstone E, Swanton C, Midgley R, Tomlinson I, Kerr D. Genetic prognostic and predictive markers in colorectal cancer. Nat Rev Cancer 2009 Jul;9(7):489-99

2008

Lee AJ, East P, Pepper S, Nicke B, Szallasi Z, Eklund AC, Downward J, Swanton C. Concordance of exon array and real-time PCR assessment of gene expression following cancer cell cytotoxic drug exposure. Cell Cycle 2008;7(24):3947-8

Other Publications

Harrison M, Swanton C. Epothilones and new analogues of the microtubule modulators in taxane-resistant disease. Expert Opin Investig Drugs 2008;17(4):523-46

Olmos D, Swanton C, de Bono J. Targeting Polo-Like Kinase: Learning Too Little Too Late? J Clin Oncol 2008;26(34):5497-9

Swanton C, Downward J. Unraveling the complexity of endocrine resistance in breast cancer by functional genomics Cancer Cell 2008;13(2):83-5

Swanton C, Szallasi Z, Brenton JD, Downward J. Functional genomic analysis of drug sensitivity pathways to guide adjuvant strategies in breast cancer. Breast Cancer Res 2008;10(5):214