Selected Publications

Tapon N, Harvey KF, Bell DW, Wahrer DCR, Schiripo TA, Haber DA and Hariharan IK. Salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 2002; 110: 467-478. PubMed

Tapon N, Moberg KH and Hariharan IK. The coupling of cell growth to the cell cycle. Curr. Opin. Cell Biol. 2001; 13: 731-737. PubMed

Tapon N, Ito N, Dickson BJ, Treisman JE and Hariharan IK The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 2001; 105: 345-355. PubMed

Primary Research Publications

2009

Genevet A, Polesello C, Blight K, Robertson F, Collinson LM, Pichaud F, Tapon N. The Hippo pathway regulates apical-domain size independently of its growth-control function. J Cell Sci 2009 Jul 15;122(Pt 14):2360-70.

Tain LS, Chowdhury RB, Tao RN, Plun-Favreau H, Moisoi N, Martins LM, Downward J, Whitworth AJ, Tapon N. Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin. Cell Death Differ. 2009 Mar 13.

2008

Andersen DS,Tapon N. Drosophila MFAP1 is required for pre-mRNA processing and G2/M progression. J Biol Chem 2008;283(45):31256-67

Dobbelaere J, Josué F, Suijkerbuijk S, Baum B,Tapon N, Raff J. A genome-wide RNAi screen to dissect centriole duplication and centrosome maturation in Drosophila. PLoS Biol 2008;6(9):e224

2007

Langton PF, Colombani J, Aerne BL, Tapon N. Drosophila ASPP regulates C-terminal Src kinase activity. Dev Cell 2007; 13(6):773-782

Polesello C, Tapon N. Salvador-Warts-Hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr Biol 2007; 17(21):1864-1870

Tseng ASK, Tapon N, Kanda H, Cigizoglu S, Edelmann L, Pellock B, White K, Hariharan IK. Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/Ras signaling pathway. Curr Biol 2007; 17(8):728-733

2006

Colombani J, Polesello C, Josue F, Tapon N. Dmp53 activates the hippo pathway to promote cell death in response to DNA damage. Curr Biol 2006; 16(14):1453-1458

Polesello C, Huelsmann S, Brown NH, Tapon N. The Drosophila RASSF homolog antagonizes the Hippo pathway. Curr Biol 2006; 16(24):2459-2465

Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumor-suppressor gene fat controls tissue growth upstream of Expanded in the Hippo signaling pathway. Curr Biol 2006; 16(21):2081-2089

2005

Arquier N, Bourouis M, Colombani J, Leopold P. Drosophila Lk6 kinase control phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development. Curr Biol 2005; 15:19-23

Colombani J, Bianchini L, Layalle S, Pondeville E, Dauphin-Villemant C, Antoniewski C, Carre C, Noselli S, Leopold P. Antagonistic actions of ecdysone and insulins determine final size in Drosophila. Science 2005; :

Other Publications

Tapon N, Ziebold U. Invasion and metastasis: stem cells, screens and survival. Conference on Invasion and Metastasis. EMBO Rep 2008;9(11):1078-83

Harvey K, Tapon N. The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nat Rev Cancer 2007; 7(3):182-191

Pantalacci S, Leopold P, Tapon N. Drosophile et cancer: la preuve par sav. [Drosophila and cancer: proof by sav.]. MS Med Sci 2003; 19(2):149-151

Pantalacci S, Tapon N, Leopold P. The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila. Nat Cell Biol 2003; 5(10):921-927

Tapon N. Modeling transformation and metastasis in Drosophila. Cancer Cell 2003; 4(5):333-335