Selected Publications
Posern G, Sotiropoulos A and Treisman R. Mutant actins reveal a role for unpolymerised actin in control of transcription by Serum Response Factor. Mol Biol Cell 2002; 13: 4167-4178. PubMed PDF (UKPMC)
Miralles F, Posern G, Zaromytidou A-I and Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 2003; 113: 329-342. PubMed
Costello PS, Nicolas RH, Watanabe Y, Rosewell I and Treisman R. Ternary Complex Factor SAP-1 is required for Erk-mediated thymocyte positive selection. Nature Immunol 2004; 5: 289-298. PubMed
Posern G, Miralles F, Guettler S and Treisman R. Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL. EMBO J 2004; 23: 3973-3983. PubMed PDF (UKPMC)
Zaromytidou A-I, Miralles F and Treisman R. MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain. Mol Cell Biol 2006; 26: 4134-4148. PubMed PDF (UKPMC)
Primary Research Publications
2009
Medjkane S, Perez-Sanchez C, Gaggioli C, Sahai E, Treisman R. Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis. Nat Cell Biol. 2009 Mar;11(3):257-68. Epub 2009 Feb 8
2008
Descot A, Rex-Haffner M, Courtois G, Bluteau D, Menssen A, Mercher T, Bernard OA, Treisman R, Posern G. OTT-MALis a deregulated activator of serum response factor dependent gene expression. Mol Cell Biol 2008;28(20):6171-81
Guettler S,Vartiainen MK, Miralles F, Larijani B, Treisman R. RPEL motifs link the serum response factor cofactor MAL but not myocardin to Rho signaling via actin binding. Mol Cell Biol 2008;28(2):732-42
Mouilleron S, Guettler, S, Langer CA, Treisman R, McDonald N. Molecular basis for G-actin binding to RPEL repeats from the serum response factor coactivator MAL. EMBO J 2008;27(23):3198-208
2007
Vartiainen MK, Guettler S, Larijani B, Treisman R. Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL. Science 2007; 316(5832):1749-1752
Willoughby JE, Costello PS, Nicolas RH, Robinson NJ, Stamp G, Powrie F, Treisman R. Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development. J Immunol 2007; 179(10):6836-6844
2006
Miralles F, Visa N. Actin in transcription and transcription regulation. Curr Opin Cell Biol 2006; 18(3):261-266
Zaromytidou AI, Miralles F, Treisman R. MAL and ternary complex factor use different mechanisms to contact a common surface on the serum response factor DNA-binding domain. Mol Cell Biol 2006; 26(11):4134-4148
2004
Copeland JW, Copeland SJ, Treisman R. Homo-oligomerization is essential for F-actin assembly by the formin family FH2 domain. J Biol Chem 2004; 279(48):50250-50256
Costello PS, Nicolas RH, Watanabe Y, Rosewell I, Treisman R. Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection. Nat Immunol 2004; 5(3):289-298
Posern G, Miralles F, Guettler S, Treisman R. Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL. EMBO J 2004; 23(20):3973-3983
2003
Graler MH, Grosse R, Kusch A, Kremmer E, Gudermann T, Lipp M. The sphingosine 1-phosphate receptor S1P(4) regulates cell shape and motility via coupling to Gi and G(12/13). J Cell Biochem 2003; 89(3):507-519
Grosse R, Copeland JW, Newsome TP, Way M, Treisman R. A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity. EMBO J 2003; 22(12):3050-3061
Miralles F, Posern G, Zaromytidou A-I, Treisman R. Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 2003; 113(3):329-342
2002
Copeland JW, Treisman R. The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization. Mol Biol Cell 2002; 13(11):4088-4099
Geneste O, Copeland JW, Treisman R. LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics. J Cell Biol 2002; 157(5):831-838
Murai K, Treisman R. Interaction of serum response factor (SRF) with the Elk-1 B box inhibits RhoA-Actin signaling to SRF and potentiates transcriptional activation by Elk-1. Mol Cell Biol 2002; 22(20):7083-7092
Posern G, Sotiropoulos A, Treisman R. Mutant actins demonstrate a role for unpolymerized actin in control of transcription by Serum Response Factor. Mol Biol Cell 2002; 13(12):4167-4178
Other Publications
Posern G, Treisman R. Actin' together: serum response factor, its cofactors and the link to signal transduction. Trends Cell Biol 2006; 16(11):588-596
Vartiainen MK, Machesky LM. The WASP-Arp2/3 pathway: genetic insights. Curr Opin Cell Biol 2004; 16(2):174-181
