Selected Publications
Ina Weisswange, Timothy P. Newsome, Sibylle Schleich and Michael Way. The rate of N-WASP exchange limits the extent of Arp2/3 complex dependent actin¿based motility. Nature 458: 87-91. 2009. PubMed
Batiste Boëda, David C. Briggs, Theresa Higgins, Boyan K. Garvalov, Andrew J. Neil Q. McDonald and Michael Way. Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. Molecular Cell 28: 1071-1082. 2007. PubMed
Yoshiki Arakawa, João V. Cordeiro, Sibylle Schleich, Tim P. Newsome and Michael Way. The release of vaccinia virus from infected cells requires RhoA-mDia modulation of cortical actin. Cell Host and Microbe 1: 227-240. 2007. PubMed
Ferran Valderrama, João V. Cordeiro, Sibylle Schleich, Friedrich Frischknecht and Michael Way. Vaccinia virus induced cell motility requires F11L-mediated inhibition of RhoA signalling. Science 311: 377-381. 2006. PubMed
Timothy P. Newsome, Niki Scaplehorn and Michael Way. Src mediates a switch from microtubule to actin-based motility of vaccinia virus. Science 306: 124-129. 2004. PubMed
Primary Research Publications
2009
Dodding MP, Newsome TP, Collinson LM, Edwards C, Way M. An E2-F12 complex is required for IEV morphogenesis during vaccinia infection. Cell Microbiol. 2009 Feb 4
Pichlmair A, Schulz O, Tan CP, Rehwinkel J, Kato H, Takeuchi O, Akira S, Way M, Schiavo G, Reis E Sousa C. Activation of MDA5 requires higher order RNA structures generated during virus infection. J Virol 2009 Aug 5.
Postigo A, Martin MC, Dodding MP, Way M. Vaccinia-induced epidermal growth factor receptor-MEK signalling and the anti-apoptotic protein F1L synergize to suppress cell death during infection. Cell Microbiol. 2009 11:1208-1218. 2009.
Weisswange I, Newsome TP, Schleich S, Way M. The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility. Nature 2009 Mar 5;458(7234):87-91.
Xu P, Crawford M, Way M, Godovac-Zimmermann J, Segal AW, Radulovic M. Subproteome analysis of the neutrophil cytoskeleton. Proteomics 2009 Apr;9(7):2037-49.
2008
Cross JR, Postigo A, Blight K, Downward J. Viral pro-survival proteins block separate stages in Bax activation but changes in mitochondrial ultrastructure still occur. Cell Death Differ 2008;15(6):997-1008
Li Y, Grenklo S, Higgins T, Karlsson R. The profilin:actin complex localizes to sites of dynamic actin polymerization at the leading edge of migrating cells and pathogen-induced actin tails. Eur J Cell Biol 2008;87(11):893-904
Roces L, Knowles PP, Fox G, Juanhuix J, Scaplehorn N,Way M, McDonald NQ. Crystallization and preliminary X-ray diffraction analysis of vaccinia virus H1L phosphatase. Acta Crystallogr Sect F Struct Biol Cryst Commun 2008;64(3):190-2
2007
Arakawa Y, Cordeiro JV, Schleich S, Newsome TP, Way M. The release of vaccinia virus from infected cells requires RhoA-mDia modulation of cortical actin. Cell Host Microbe 2007; 1(3):227-240
Arakawa Y, Cordeiro JV, Way M. F11L-mediated inhibition of RhoA-mDia signaling stimulates microtubule dynamics during Vaccinia virus infection. Cell Host Microbe 2007; 1(3):213-226
Boeda B, Briggs DC, Higgins T, Garvalov BK, Fadden AJ, McDonald NQ, Way M. Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding. Mol Cell 2007; 28(6):1071-1082
Bracale A, Cesca F, Neubrand VE, Newsome TP, Way M, Schiavo G. Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation. Mol Biol Cell 2007; 18(1):142-152
Peterson FC, Deng Q, Zettl M, Prehoda KE, Lim WA, Way M, Volkman BF. Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP. J Biol Chem 2007; 282(11):8446-8453
Unsworth KE, Mazurkiewicz P, Senf F, Zettl M, McNiven M, Way M, Holden DW. Dynamin is required for F-actin assembly and pedestal formation by enteropathogenic Escherichia coli (EPEC). Cell Microbiol 2007; 9(2):438-449
2006
Jouvenet N, Windsor M, Rietdorf J, Hawes P, Monaghan P, Way M, Wileman T. African swine fever virus induces filopodia-like projections at the plasma membrane. Cell Microbiol 2006; 8(11):1803-1811
Newsome TP, Weisswange I, Frischknecht F, Way M. Abl collaborates with Src family kinases to stimulate actin-based motility of vaccinia virus. Cell Microbiol 2006; 8(2):233-241
Postigo A, Cross JR, Downward J, Way M. Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis. Cell Death Differ 2006; 13(10):1651-1662
Redd MJ, Kelly G, Dunn G, Way M, Martin P. Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammation. Cell Motil Cytoskeleton 2006; 63(7):415-422
Valderrama F, Cordeiro JV, Schleich S, Frischknecht F, Way M. Vaccinia virus-induced cell motility requires F11L-mediated inhibition of RhoA signaling. Science 2006; 311(5759):377-381
2005
Kempiak SJ, Yamaguchi H, Sarmiento C, Sidani M, Ghosh M, Eddy RJ, DesMarais V, Way M, Condeelis J, Segall JE. A neural Wiskott-Aldrich syndrome protein-mediated pathway for localized activation of actin polymerization that is regulated by cortactin. J Biol Chem 2005; 280(7):5836-5842
2004
Beranek A, Zettl M, Lorenzoni K, Schauer A, Manhart M, Koraimann G. Thirty-eight C-terminal amino acids of the coupling protein TraD of the F-like conjugative resistance plasmid R1 are required and sufficient to confer binding to the substrate selector protein TraM. J Bacteriol 2004; 186(20):6999-7006
Gasman S, Chasserot-Golaz S, Malacombe M, Way M, Bader M-F. Regulated exocytosis in neuroendocrine cells: a role for subplasmalemmal Cdc42/N-WASP-induced actin filaments. Mol Biol Cell 2004; 15(2):520-531
Jouvenet N, Monaghan P, Way M, Wileman T. Transport of African swine fever virus from assembly sites to the plasma membrane is dependent on microtubules and conventional kinesin. J Virol 2004; 78(15):7990-8001
Krause M, Leslie JD, Stewart M, Lafuente EM, Valderrama F, Jagannathan R, Strasser GA, Rubinson DA, Liu H, Way M, Yaffe MB, Boussiotis VA, Gertler FB. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Dev Cell 2004; 7(4):571-583
Newsome TP, Scaplehorn N, Way M. Src mediates a switch from microtubule- to actin-based motility of vaccinia virus. Science 2004; 306(5693):124-129
Spinardi L, Rietdorf J, Nitsch L, Bono M, Tacchetti C, Way M, Marchisio PC. A dynamic podosome-like structure of epithelial cells. Exp Cell Res 2004; 295(2):360-374
Unsworth KE, Way M, McNiven M, Machesky L, Holden DW. Analysis of the mechanisms of Salmonella-induced actin assembly during invasion of host cells and intracellular replication. Cell Microbiol 2004; 6(11):1041-1055
2003
Garvalov BK, Higgins TE, Sutherland JD, Zettl M, Scaplehorn N, Kocher T, Piddini E, Griffiths G, Way M. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. J Cell Biol 2003; 161(1):33-39
Grosse R, Copeland JW, Newsome TP, Way M, Treisman R. A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity. EMBO J 2003; 22(12):3050-3061
Harlander RS, Way M, Ren Q, Howe D, Grieshaber SS, Heinzen RA. Effects of ectopically expressed neuronal Wiskott-Aldrich syndrome protein domains on Rickettsia rickettsii actin-based motility. Infect Immun 2003; 71(3):1551-1556
Zeng R, Cannon JL, Abraham RT, Way M, Billadeau DD, Bubeck-Wardenberg J, Burkhardt JK. SLP-76 coordinates Nck-dependent Wiskott-Aldrich syndrome protein recruitment with Vav-1/Cdc42-dependent Wiskott-Aldrich syndrome protein activation at the T cell-APC contact site. J Immunol 2003; 171(3):1360-1368
2002
Benesch S, Lommel S, Steffen A, Stradal TEB, Scaplehorn N, Way M, Wehland J, Rottner K. Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2. J Biol Chem 2002; 277(40):37771-37776
Jiang ZY, Chawla A, Bose A, Way M, Czech MP. A phosphatidylinositol 3-kinase-independent insulin signaling pathway to N-WASP/Arp2/3/F-actin required for GLUT4 glucose transporter recycling. J Biol Chem 2002; 277(1):509-515
Luna A, Matas OB, Martinez-Menarguez JA, Mato E, Duran JM, Ballesta J, Way M, Egea G. Regulation of protein transport from the golgi complex to the endoplasmic reticulum by CDC42 and N-WASP. Mol Biol Cell 2002; 13(3):866-879
Scaplehorn N, Holmstrom A, Moreau V, Frischknecht F, Reckmann I, Way M. Grb2 and Nck act cooperatively to promote actin-based motility of vaccinia virus. Curr Biol 2002; 12(9):740-745
Zettl M, Way M. The WH1 and EVH1 domains of WASP and Ena/VASP family members bind distinct sequence motifs. Curr Biol 2002; 12(18):1617-1622
Other Publications
Freddy Frischknecht, Maria Mota, Michael Way, Spencer Shorte. Hidden treasures from the archives. Biotechnology Journal 4: 784-785. 2009
Greber UF, Way M. A superhighway to virus infection. Cell 2006; 124(4):741-754
Munter S, Way M, Frischkencht F. Signaling during pathogen infection. Sci STKE 2006; 335:re5
Sutherland JD, Way M. Looking over the edge: a new role for Ena/VASP proteins in lamellipodial dynamics. Dev Cell 2002; 2(6):692-694
