Selected Publications
Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW, and West SC. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature 2006; 443: 713-716.PubMed
Constantinou A, Davies AA and West SC. Branch migration and Holliday junction resolution catalyzed by activities from mammalian cells. Cell 2001; 104: 259-268. PubMed
West SC. Molecular views of recombination proteins and their control. Nat Rev Mol Cell Biol 2003; 4: 435-445. PubMed
Liu Y, Masson J-Y, Shah R, O'Regan P and West SC. RAD51C is required for Holliday junction processing in mammalian cells. Science 2004; 303: 243-246. PubMed
Esashi F, Christ N, Gannon J, Liu Y, Hunt T, Jasin M and West SC. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 2005; 434: 598-604. PubMed
Primary Research Publications
2009
Ahel D, Horejsi Z, Wiechens N, Polo SE, Garcia-Wilson E, Ahel I, Flynn H, Skehel M, West SC, Jackson SP, Owen-Hughes T, Boulton SJ. Poly(ADP-ribose)-Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1. Science 2009 Aug 6
Poulet A, Buisson R, Faivre-Moskalenko C, Koelblen M, Amiard S, Montel F, Cuesta-Lopez S, Bornet O, Guerlesquin F, Godet T, Moukhtar J, Argoul F, D¿clais AC, Lilley DM, Ip SC, West SC, Gilson E, Giraud-Panis MJ. TRF2 promotes, remodels and protects telomeric Holliday junctions. EMBO J. 2009 Mar 18;28(6):641-51.
West SC. The search for a human Holliday junction resolvase. Biochem Soc Trans. 2009 Jun;37(Pt 3):519-26.
2008
Ahel I, Ahel D, Matsusaka T, Clark AJ, Pines J, Boulton SJ, West SC. Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature 2008;451(7174):81-5
Barber LJ,Youds JL,Ward JD, McIlwraith MJ, O¿Neil NJ, Petalcorin MI, Martin JS, Collis SJ, Cantor SB,Auclair M, Tissenbaum H,West SC, Rose AM, Boulton SJ. RTEL1 maintains genomic stability by suppressing homologous recombination. Cell 2008;135(2):261-71
Collis SJ, Ciccia A, Deans AJ, Horejsi Z, Martin JS, Maslen SL, Skehel JM, Elledge SJ, West SC, Boulton SJ. FANCM and FAAP24 function in ATR-mediated checkpoint signaling independently of the Fanconi anemia core complex. Mol Cell 2008;32(3):313-24
Ip SC, Rass U, Blanco MG, Flynn HR, Skehel JM, West SC. Identification of Holliday junction resolvases from humans and yeast. Nature 2008;456(7220):357-61
McIlwraith MJ,West SC. DNA repair synthesis facilitates RAD52-mediated second-end capture during DSB repair. Mol Cell 2008;29(4):510-6
Rass U, Ahel I,West SC. Molecular mechanism of DNA deadenylation by the neurological disease protein aprataxin. J Biol Chem 2008;283(49):33994-4001
Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, Takeda S, Hay RT, Gautier J, West SC, Paull TT, Pandita TK, White MF, Khanna KK. Single-stranded DNA binding protein hSSB1 is critical for genomic stability. Nature 2008;453(7195):677-81
2007
Ciccia A, Ling C, Coulthard R, Yan ZJ, Xue YT, Meetei AR, Laghmani El H, Joenje H, McDonald N, de Winter JP, Wang WD, West SC. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell 2007; 25(3):331-343
Esashi F, Galkin VE, Yu X, Egelman EH, West SC. Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nat Struct Mol Biol 2007; 14(6):468-474
Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu YL, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK. RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. J Cell Biol 2007; 176(5):581-592
Liu YL, Tarsounas M, O'Regan P, West SC. Role of RAD51C and XRCC3 in genetic recombination and DNA repair. J Biol Chem 2007; 282(3):1973-1979
Rass U, Ahel I, West SC. Actions of aprataxin in multiple DNA repair pathways. J Biol Chem 2007; 282(13):9469-9474
Stewart GS, Stankovic T, Byrd PJ, Wechsler T, Miller ES, Huissoon A, Drayson MT, West SC, Elledge SJ, Taylor AMR. RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling. Proc Natl Acad Sci U S A 2007; 104(43):16910-16915
Thorslund T, Esashi F, West SC. Interactions between human BRCA2 protein and the meiosis-specific recombinase DMC1. EMBO J 2007; 26(12):2915-2922
2006
Ahel I, Rass U, El-Khamisy SF, Katyal S, Clements PM, McKinnon PJ, Caldecott KW, West SC. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature 2006; 443(7112):713-716
Rodrigue A, Lafrance M, Gauthier M-C, McDonald D, Hendzel M, West SC, Jasin M, Masson J-Y. Interplay between human DNA repair proteins at a unique double-strand break in vivo. EMBO J 2006; 25(1):222-231
2005
Esashi F, Christ N, Gannon J, Liu Y, Hunt T, Jasin M, West SC. CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 2005; 434(7033):598-604
Galkin VE, Esashi F, Yu X, Yang S, West SC, Egelman EH. BRCA2 BRC motifs bind RAD51-DNA filaments. Proc Natl Acad Sci U S A 2005; 102(24):8537-8542
Martin JS, Winkelmann N, Petalcorin MIR, McIlwraith MJ, Boulton SJ. RAD-51-dependent and -independent roles of a Caenorhabditis elegans BRCA2-related protein during DNA double-strand break repair. Mol Cell Biol 2005; 25(8):3127-3139
McIlwraith MJ, Vaisman A, Liu Y, Fanning E, Woodgate R, West SC. Human DNA polymerase eta promotes DNA synthesis from strand invasion intermediates of homologous recombination. Mol Cell 2005; 20(5):783-792
Tarsounas M, West SC. Recombination at mammalian telomeres: an alternative mechanism for telomere protection and elongation. Cell Cycle 2005; 4(5):672-674
2004
Garcia PL, Liu Y, Jiricny J, West SC, Janscak P. Human RECQ5 beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide. EMBO J 2004; 23(14):2882-2891
Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson J-Y, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG. Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways. Hum Mol Genet 2004; 13(12):1241-1248
Liu Y, Masson J-Y, Shah R, O'Regan P, West SC. RAD51C is required for Holliday junction processing in mammalian cells. Science 2004; 303(5655):243-246
Liu Y, Stasiak AZ, Masson J-Y, McIlwraith MJ, Stasiak A, West SC. Conformational changes modulate the activity of human RAD51 protein. J Mol Biol 2004; 337(4):817-827
Tarsounas M, Davies AA, West SC. RAD51 localization and activation following DNA damage. Philos Trans R Soc Lond B Biol Sci 2004; 359(1441):87-93
Tarsounas M, Munoz P, Claas A, Smiraldo PG, Pittman DL, Blasco MA, West SC. Telomere maintenance requires the RAD51D recombination/repair protein. Cell 2004; 117(3):337-347
2003
Abraham J, Lemmers B, Hande MP, Moynahan ME, Chahwan C, Ciccia A, Essers J, Hanada K, Chahwan R, Khaw AK, McPherson P, Shehabeldin A, Laister R, Arrowsmith C, Kanaar R, West SC, Jasin M, Hakem R. Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. EMBO J 2003; 22(22):6137-6147
Ciccia A, Constantinou A, West SC. Identification and characterization of the human Mus81-Eme1 endonuclease. J Biol Chem 2003; 278(27):25172-25178
Dai Y, Kysela B, Hanakahi LA, Manolis K, Riballo E, Stumm M, Harville TO, West SC, Oettinger MA, Jeggo PA. Nonhomologous end joining and V(D)J recombination require an additional factor. Proc Natl Acad Sci U S A 2003; 100(5):2462-2467
Henry-Mowatt J, Jackson D, Masson J-Y, Johnson PA, Clements PM, Benson FE, Thompson LH, Takeda S, West SC, Caldecott KW. XRCC3 and Rad51 modulate replication fork progression on damaged vertebrate chromosomes. Mol Cell 2003; 11(4):1109-1117
Madsen B, Tarsounas M, Burchell JM, Hall D, Poulsom R, Taylor-Papadimitriou J. PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis. Chromosoma 2003; 112(3):124-132
Tarsounas M, Davies D, West SC. BRCA2-dependent and independent formation of RAD51 nuclear foci. Oncogene 2003; 22(8):1115-1123
2002
Chappell C, Hanakahi LA, Karimi-Busheri F, Weinfeld M, West SC. Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J 2002; 21(11):2827-2832
Constantinou A, Chen X-B, McGowan CH, West SC. Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities. EMBO J 2002; 21(20):5577-5585
French CA, Masson J-Y, Griffin CS, O'Regan P, West SC, Thacker J. Role of mammalian RAD51L2 (RAD51C) in recombination and genetic stability. J Biol Chem 2002; 277(22):19322-19330
Hanakahi LA, West SC. Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK. EMBO J 2002; 21(8):2038-2044
Moens PB, Kolas NK, Tarsounas M, Marcon E, Cohen PE, Spyropoulos B. The time course and chromosomal localization of recombination-related proteins at meiosis in the mouse are compatible with models that can resolve the early DNA-DNA interactions without reciprocal recombination. J Cell Sci 2002; 115(8):1611-1622
Singleton MR, Wentzell LM, Liu YL, West SC, Wigley DB. Structure of the single-strand annealing domain of human RAD52 protein. Proc Natl Acad Sci U S A 2002; 99(21):13492-13497
Other Publications
Ciccia A, McDonald N, West SC. Structural and functional relationships of the XPF/MUS81 family of proteins. Annu Rev Biochem 2008;77:259-87
Liu Y, West SC. More complexity to the Bloom¿s syndrome complex. Genes Dev 2008;22(20):2737-42
Rass U, Ahel I, West SC. Defective DNA repair and Neurodegenerative disease. Cell 2007; 130(6):991-1004
Thorslund T, West SC. BRCA2: a universal recombinase regulator. Oncogene 2007; 26(56):7720-7730
Bleuyard J-Y, Gallego ME, White CI. Recent advances in understanding of the DNA double-strand break repair machinery of plants. DNA Repair 2006; 5(1):1-12
Rass U, West SC. Synthetic junctions as tools to identify and characterize Holliday junction resolvases. Methods Enzymol 2006; 408:485-501
Constantinou A, West SC. Holliday junction branch migration and resolution assays. Methods Mol Biol 2004; 262:239-253
Liu Y, West SC. Happy Hollidays: 40th anniversary of the Holliday junction. Nat Rev Mol Cell Biol 2004; 5(11):937-946
Sherratt DJ, West SC. Replicating and reshaping DNA: a celebration of the jubilee of the double helix. Introduction. Philos Trans R Soc Lond B Biol Sci 2004; 359(1441):3-5
Surralles J, Jackson SP, Jasin M, Kastan MB, West SC, Joenje H. Molecular cross-talk among chromosome fragility syndromes. Genes Dev 2004; 18(12):1359-1370
West SC. Cross-links between Fanconi anaemia and BRCA2. DNA Repair 2003; 2(2):231-234
West SC. Molecular views of recombination proteins and their control. Nat Rev Mol Cell Biol 2003; 4(6):435-445
Liu YL, West SC. Distinct functions of BRCA1 and BRCA2 in double-strand break repair. Breast Cancer Res 2002; 4(1):9-13
