Selected Publications

Forbes SJ, Russo FP, Rey V, Burra P, Rugge M, Wright NA and Alison MR. A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology 2004; 126: 955-963. PubMed

Direkze NC, Forbes SJ, Brittan M, Hunt T, Jeffery R, Preston SL, Poulsom R, Hodivala-Dilke K, Alison MR and Wright NA. Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow transplanted mice. Stem Cell 2003; 21: 514-520. PubMed

Preston SL, Wong W-M, Chan AO-O, Poulsom R, Jeffery R, Goodlad RA, Mandir N, Elia G, Novelli M, Bodmer WF, Tomlinson IP and Wright NA. Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission. Cancer Res 2003; 63: 3819-3825. PubMed

Novelli M, Cossu A, Oukrif D, Quaglia A, Lakhani S, Poulsom R, Sasieni P, Carta P, Contini M, Pasca A, Palmieri G, Bodmer W, Tanda F and Wright NA. X-inactivation patch size in human female tissue confounds the assessment of tumor clonality. Proc Natl Acad Sci USA 2003; 100: 3311-3314. PubMed

Alison MR, Poulsom R, Jeffery R, Dhillon AP, Quaglia A, Jacob J, Novelli M, Prentice G, Williamson J and Wright NA. Hepatocytes from non-hepatic adult stem cells. Nature 2000; 406: 257. PubMed

Primary Research Publications

2009

Fellous TG, McDonald SA, Burkert J, Humphries A, Islam S, De-Alwis NM, Gutiérrez-González L, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, El-Bahrawy M, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Day CP, Wright NA, Alison MR. A Methodological Approach to Tracing Cell Lineage in Human Epithelial Tissues. Stem Cells 2009 Mar 19;27(6):1410-1420.

Fellous TG, Islam S, Tadrous PJ, Elia G, Kocher HM, Bhattacharya S, Mears L, Turnbull DM, Taylor RW, Greaves LC, Chinnery PF, Taylor G, McDonald SA, Wright NA, Alison MR. Locating the stem cell niche and tracing hepatocyte lineages in human liver. Hepatology. 2009 May;49(5):1655-63.

Gutiérrez-González L, Deheragoda M, Elia G, Leedham SJ, Shankar A, Imber C, Jankowski JA, Turnbull DM, Novelli M, Wright NA, McDonald SA. Analysis of the clonal architecture of the human small intestinal epithelium establishes a common stem cell for all lineages and reveals a mechanism for the fixation and spread of mutations. J Pathol. 2009 Mar;217(4):489-96.

Leedham SJ, Graham TA, Oukrif D, McDonald SA, Rodriguez-Justo M, Harrison RF, Shepherd NA, Novelli MR, Jankowski JA, Wright NA. Clonality, founder mutations, and field cancerization in human ulcerative colitis-associated neoplasia. Gastroenterology 2009 Feb;136(2):542-50.e6. Epub 2008 Nov 7.

McDonald SA, Graham TA, Schier S, Wright NA, Alison MR. Stem cells and solid cancers. Virchows Arch 2009 Jun 5.

2008

Burkert J, Otto WR,Wright NA. Side populations of gastrointestinal cancers are not enriched in stem cells. J Pathol 2008;214(5):564-73

Fang TC, Otto WR, Jeffery R, Hunt T, Alison MR, Cook HT, Wright NA, Poulsom R. Exogenous bone marrow cells do not rescue non-irradiated mice from acute renal tubular damage caused by HgCl2, despite establishment of chimaerism and cell proliferation in bone marrow and spleen. Cell Prolif 2008;41(4):592-606

Fang TC, Otto WR, Rao J, Jeffery R, Hunt T, Alison MR, Cook HT,Wright NA, Poulsom R. Haematopoietic lineage committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl 2-induced acute tubular injury. Cell Prolif 2008;41(4):575-91

Leedham SJ, Preston SL, McDonald SA, Elia G, Bhandari P, Poller D, Harrison R, Novelli MR, Jankowski JA, Wright NA. Individual crypt genetic heterogeneity and the origin of metaplastic glandular epithelium in human Barrett's oesophagus. Gut 2008;57(8):1041-8

Leedham SJ, Wright NA. Expansion of a mutated clone: from stem cell to tumour. J Clin Pathol 2008;61(2):164-71

Jones AM, Mitter R, Poulsom R, Gillett C, Hanby AM, Tomlinson IP, Sawyer EJ; Phyllodes Tumour Consortium. mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours. J Pathol 2008;216(4):408-17

McDonald SA, Greaves LC, Gutiérrez-González L, Rodriguez-Justo M, Deheragoda M, Leedham SJ, Taylor RW, Lee CY, Preston SL, Lovell M, Hunt T, Elia G, Oukrif D, Harrison R, Novelli MR, Mitchell I, Stoker DL,Turnbull DM, Jankowski JA,Wright NA. Mechanisms of field cancerization in the human stomach: the expansion and spread of mutated gastric stem cells. Gastroenterology 2008 Feb;134(2):500-10

Milicic A, Harrison LA, Goodlad RA, Hardy RG, Nicholson AM, Presz M, Sieber O, Santander S, Pringle JH, Mandir N, East P, Obszynska J, Sanders S, Piazuelo E, Shaw J, Harrison R,Tomlinson IP, McDonald SA,Wright NA, Jankowski JA. Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo. Cancer Res 2008;68(19):7760-8

Preston SL, Leedham SJ, Oukrif D, Deheregoda M, Goodlad RA, Poulsom R, Alison MR, Wright NA, Novelli M. The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse J Pathol 2008;214(3):294-301

Segditsas S, Rowan AJ, Howarth K, Jones A, Leedham S, Wright NA, Gorman P, Chambers W, Domingo E, Roylance RR, Sawyer EJ, Sieber OM, Tomlinson IP. APC and the three-hit hypothesis. Oncogene 2008; doi:10.1038/onc.2008.361

2007

Alferez D, Goodlad RA. To best measure cell proliferation in samples from the intestine. Cell Proliferation 2007; 40: 231-40.

Alison MR, Murphy G, Leedham S. Stem cells and cancer: a deadly mix. Cell and Tissue Research 2008; 331(1):109-124.

Alison MR, Choong C, Lim S. Application of liver stem cells for therapy. Seminars in Cell and Developmental Biology, e-Published 2 Oct 2007, doi: 10.1016/j.semcdb.2007.09.016.

Baus-Loncar M, Lubka M, Pusch CM, Otto WR, Poulsom R, Blin N. Cytokine regulation of the trefoil factor family binding protein GKN2 (GDDR/TFIZ1/blottin) in human gastrointestinal epithelial cells. Cellular Physiology and Biochemistry 2007; 20: 193-204.

Burkert J, Wright NA, Otto WR. Non-side population cells in gastrointestinal cancer cell lines contain cells with stem cell characteristics. Journal of Pathology 2007; 213: 161-169.

Esseghir S, Kennedy A, Seedhar P, Nerurkar A, Poulsom R, Reis JS, Isacke CM. Identification of NTN4, TRA1, and STC2 as prognostic markers in breast cancer in a screen for signal sequence encoding proteins. Clinical Cancer Research 2007; 13: 3164-3173.

Esseghir S, Todd SK, Hunt T, Poulsom R, Plaza-Menacho I, Reis-Filho JS, Isacke CM. A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET/GFR alpha 1 receptor up-regulation in breast cancer. Cancer Research 2007; 67: 11732-11741.

Harrison R, Perry I, Haddadin W, McDonald S, Bryan R, Abrams K, Sampliner R, Talley NJ, Moayyadi P, Jankowski JA. Detection of intestinal metaplasia in Barrett's esophagus: an observational comparator study suggests the need for a minimum of eight biopsies. American Journal of Gastroenterology 2007; 102: 1154-1161.

Kallis YN, Alison M, Forbes SJ. Bone marrow stem cells and liver disease. Gut 2007; 56: 716-724.

Lin WR, Lin DY, Tai DI, Hsieh SY, Lin CY, Sheen IS, Chiu CT. Prevalence of and risk factors for gallbladder polyps detected by ultrasonography among healthy Chinese: Analysis of 34 669 cases. Journal of Gastroenterology and Hepatology e-Published 27 Aug 2007, doi: 10.1111/j.1440-1746.2007.05071.x.

Marchbank T, Mahmood A, Fitzgerald AJ, Domin J, Butler M, Goodlad RA, Elia G, Cox HM, van Heel DA, Ghosh S, Playford RJ. Human pancreatic secretory trypsin inhibitor stabilises intestinal mucosa against noxious agents. American Journal of Pathology 2007; 171: 1462-1473.

Minegishi Y, Suzuki H, Arakawa M, Fukushima Y, Masaoka T, Ishikawa T, Wright NA, Hibi T. Reduced Shh expression in TFF2-overexpressing lesions of the gastric fundus under hypochlorhydric conditions. J Pathol 2007; 213(2):161-169

Pera M, Pera M, de Bolos C, Brito MJ, Palacin A, Grande L, Cardesa A, Poulsom R. Duodenal-content reflux into the esophagus leads to expression of Cdx2 and Muc2 in areas of squamous epithelium in rats. Journal of Gastrointestinal Surgery 2007; 11: 869-874.

Plumb DA, Dhir V, Mironov A, Ferrara L, Poulsom R, Kadler KE, Thornton DJ, Briggs MD, Boot-Handford RP. Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens. Journal of Biological Chemistry 2007; 282: 12791-12795.

Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M, McDonald S, Martin A, Igarashi P, Varsani-Brown S, Rosewell I, Poulsom R, Maxwell P, Stamp GW, Tomlinson IPM. Targeted inactivation of Fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell 2007; 11: 311-319.

Poulsom R. CD44 and hyaluronan help mesenchymal stem cells move to a neighborhood in need of regeneration. Kidney International 2007; 72: 389-390.

Russo FP, Kallis YN, Alison M, Forbes SJ. Bone marrow cells in the liver: diverse cells, diverse effects. Hepatology 2007; 46: 604-605.

Sullivan PB, Lewindon PJ, Cheng C, Lenehan PF, Kuo BS, Haskins JR, Goodlad RA, Wright NA, dela Iglesia FA. Intestinal mucosa remodeling by recombinant human epidermal growth factor(1-48) in neonates with severe necrotizing enterocolitis. J Pediatr Surg 2007; 42(3):462-469

Tosh D, Shen CN, Alison MR, Sarraf CE, Slack JM. Copper deprivation in rats induces islet hyperplasia and hepatic metaplasia in the pancreas. Biology of the Cell 2007: 99: 37-44.

Walsh MJ, Fellous TG, Hammiche A, Lin WR, Fullwood NJ, Grude O, Bahrami F, Nicholson JM, Cotte M, Susini J, Pollock HM, Brittan M, Martin-Hirsch PL, Alison MR, Martin FL. FTIR micro-spectroscopy identifies symmetric PO2- modifications as a marker of the putative stem cell region of human intestinal crypts. Stem Cells, e-Published 27 Sep 2007, doi: 10.1634/stemcells.2007-0196.

Watson AR, Jankowski JJ. Hyperplastic polyps, serrated adenomas, and the serrated polyp neoplasia pathway. Current Colorectal Cancer Reports 2007; 3: 3-9.

Yen TH, Alison MR, Cook HT, Jeffery R, Otto WR, Wright NA, Poulsom R. The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment. Cell Prolif 2007; 40(2):143-156

2006

Anand U, Otto WR, Casula MA, Day NC, Davis JB, Bountra C, Birch R, Anand P. The effect of neurotrophic factors on morphology, TRPV1 expression and capsaicin responses of cultured human DRG sensory neurons. Neurosci Lett 2006; 399(1-2):51-56

Bamba S, Lee C-Y, Brittan M, Preston S, Direkze NC, Poulsom R, Alison MR, Wright N. Bone marrow transplantation ameliorates pathology in interleukin-10 knockout colitic mice. J Pathol 2006; 209(2):265-273

Bigger BW, Siapati EK, Mistry A, Waddington SN, Nivsarkar MS, Jacobs L, Perrett R, Holder MV, Ridler C, Kemball-Cook G, Ali RR, Forbes SJ, Coutelle C, Wright N, Alison M, Thrasher AJ, Bonnet D, Themis M. Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX. Gene Ther 2006; 13(2):117-126

Brocker V, Langer F, Fellous TG, Mengel M, Brittan M, Bredt M, Milde S, Welte T, Eder M, Haverich A, Alison MR, Kreipe H, Lehmann U. Fibroblasts of recipient origin contribute to bronchiolitis obliterans in human lung transplants. Am J Respir Crit Care Med 2006; 173(11):1276-1282

Carvajal-Carmona LG, Alam NA, Pollard PJ, Jones AM, Barclay E, Wortham N, Pignatelli M, Freeman A, Pomplun S, Ellis I, Poulsom R, El-Bahrawy MA, Berney DM, Tomlinson IPM. Adult Leydig cell tumors of the testis caused by germline fumarate hydratase mutations. J Clin Endocrinol Metab 2006; 91(8):3071-3075

Cibrian D, Ajameih H, Berlanga J, Leon OS, Alba JS, Kim MJ-T, Marchbank T, Boyle JJ, Freyre F, Garcia Del Barco D, Lopez-Saura P, Guillen G, Ghosh S, Goodlad RA, Playford RJ. Use of growth-hormone-releasing peptide-6 (GHRP-6) for the prevention of multiple organ failure. Clin Sci 2006; 110(5):563-573

Direkze NC, Jeffery R, Hodivala-Dilke K, Hunt T, Playford RJ, Elia G, Poulsom R, Wright NA, Alison MR. Bone marrow-derived stromal cells express lineage-related messenger RNA species. Cancer Res 2006; 66(3):1265-1269

Esseghir S, Reis-Filho JS, Kennedy A, James M, O'Hare MJ, Jeffery R, Poulsom R, Isacke CM. Identification of transmembrane proteins as potential prognostic markers and therapeutic targets in breast cancer by a screen for signal sequence encoding transcripts. J Pathol 2006; 210(4):420-430

Goodlad RA, Ryan AJ, Wedge SR, Pyrah IT, Alferez D, Poulsom R, Smith NR, Mandir N, Watkins AJ, Wilkinson RW. Inhibiting vascular endothelial growth factor receptor-2 signaling reduces tumor burden in the ApcMin/+ mouse model of early intestinal cancer. Carcinogenesis 2006; 27(10):2133-2139

Greaves LC, Preston SL, Tadrous PJ, Taylor RW, Barron MJ, Oukrif D, Leedham SJ, Deheragoda M, Sasieni P, Novelli MR, Jankowski JAZ, Turnbull DM, Wright NA, McDonald SAC. Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission. Proc Natl Acad Sci U S A 2006; 103(3):714-719

Hull MA, Faluyi OO, Ko CWS, Holwell S, Scott DJ, Cuthbert RJ, Poulsom R, Goodlad R, Bonifer C, Markham AF, Coletta PL. Regulation of stromal cell cyclooxygenase-2 in the Apc(Min/+) mouse model of intestinal tumorigenesis. Carcinogenesis 2006; 27(3):382-391

Kelly P, Bajaj-Elliott M, Katubulushi M, Zulu I, Poulsom R, Feldman RA, Bevins CL, Dhaliwal W. Reduced gene expression of intestinal alpha-defensins predicts diarrhea in a cohort of African adults. J Infect Dis 2006; 193(10):1464-1470

Longman RJ, Poulsom R, Corfield AP, Warren BF, Wright NA, Thomas MG. Alterations in the composition of the supramucosal defense barrier in relation to disease severity of ulcerative colitis. J Histochem Cytochem 2006; 54(12):1335-1348

Otto WR, Patel K, McKinnell I, Evans MD, Lee C-Y, Frith D, Hanrahan S, Blight K, Blin N, Kayademir T, Poulsom R, Jeffery R, Hunt T, Wright NA, McGregor F, Oien KA. Identification of blottin: a novel gastric trefoil factor family-2 binding protein. Proteomics 2006; 6(15):4235-4245

Patel NS, Dobbie MS, Rochester M, Steers G, Poulsom R, Le Monnier K, Cranston DW, Li J-L, Harris AL. Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer. Clin Cancer Res 2006; 12(16):4836-4844

Playford RJ, Belo A, Poulsom R, Fitzgerald AJ, Harris K, Pawluczyk I, Ryon J, Darby T, Nilsen-Hamilton M, Ghosh S, Marchbank T. Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair. Gastroenterology 2006; 131(3):809-817

Pollard PJ, El-Bahrawy M, Poulsom R, Elia G, Killick P, Kelly G, Hunt T, Jeffery R, Seedhar P, Barwell J, Latif F, Gleeson MJ, Hodgson SV, Stamp GW, Tomlinson IPM, Maher ER. Expression of HIF-1alpha, HIF-2alpha(EPAS1), and their target genes in paraganglioma and phaeochromocytoma with VHL and S DH mutations. J Clin Endocrinol Metab 2006; 91(11):4593-4598

Prodromidi EI, Poulsom R, Jeffery R, Roufosse CA, Pollard PJ, Pusey CD, Cook HT. Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome. Stem Cells 2006; 24(11):2448-2455

Roufosse C, Bou-Gharios G, Prodromidi E, Alexakis C, Jeffery R, Khan S, Otto WR, Alter J, Poulsom R, Cook HT. Bone marrow-derived cells do not contribute significantly to collagen I synthesis in a murine model of renal fibrosis. J Am Soc Nephrol 2006; 17(3):775-782

Rudling R, Hassan AB, Kitau J, Mandir N, Goodlad RA. A simple device to rapidly prepare whole mounts of murine intestine. Cell Prolif 2006; 39(5):415-420

Russo FP, Alison MR, Bigger BW, Amofah E, Florou A, Amin F, Bou-Gharios G, Jeffery R, Iredale JP, Forbes SJ. The bone marrow functionally contributes to liver fibrosis. Gastroenterology 2006; 130(6):1807-1821

Schmidt C, Otto A, Luke G, Valasek P, Otto WR, Patel K. Expression and regulation of Nkd-1, an intracellular component of wnt signalling pathway in the chick embryo. Anat Embryol 2006; 211(5):525-534

Vig P, Russo FP, Edwards RJ, Tadrous PJ, Wright NA, Thomas HC, Alison MR, Forbes SJ. The sources of parenchymal regeneration after chronic hepatocellular liver injury in mice. Hepatology 2006; 43(2):316-324

Walters JRF, Balesaria S, Chavele K-M, Taylor V, Berry JL, Khair U, Barley NF, van Heel DA, Field J, Hayat JO, Bhattacharjee A, Jeffery R, Poulsom R. Calcium channel TRPV6 expression in human duodenum: different relationships to the vitamin D system and aging in men and women. J Bone Miner Res 2006; 21(11):1770-1777

Wortham NC, Alam NA, Barclay E, Pollard PJ, Wagner BE, Manek S, Elia G, Tomlinson IPM. Aberrant expression of apoptosis proteins and ultrastructural aberrations in uterine leiomyomas from patients with hereditary leiomyomatosis and renal cell carcinoma. Fertil Steril 2006; 86(4):961-971

Yen TH, Wright NA. The gastrointestinal tract stem cell niche. Stem Cell Rev 2006; 2(3):203-212

2005

Albera C, Polak JM, Janes S, Griffiths MJD, Alison MR, Wright NA, Navaratnarasah S, Poulsom R, Jeffery R, Fisher C, Burke M, Bishop AE. Repopulation of human pulmonary epithelium by bone marrow cells: a potential means to promote repair. Tissue Eng 2005; 11(7-8):1115-1121

Baus-Loncar M, Schmid J, Lalani E-N, Rosewell I, Goodlad RA, Stamp GWH, Blin N, Kayademir T. Trefoil factor 2 (Tff2) deficiency in murine digestive tract influences the immune system. Cell Physiol Biochem 2005; 16(1-3):31-42

Brittan M, Braun KM, Reynolds LE, Conti FJ, Reynolds AR, Poulsom R, Alison MR, Wright NA, Hodivala-Dilke KM. Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion. J Pathol 2005; 205(1):1-13

Brittan M, Chance V, Elia G, Poulsom R, Alison MR, MacDonald TT, Wright NA. A regenerative role for bone marrow following experimental colitis: contribution to neovasculogenesis and myofibroblasts. Gastroenterology 2005; 128(7):1984-1995

Chang C-T, Hung C-C, Ng K-K, Yen T-H. Nutcracker syndrome and left unilateral haematuria. Nephrol Dial Transplant 2005; 20(2):460-461

Coad RA, Woodman AC, Warner PJ, Barr H, Wright NA, Shepherd NA. On the histogenesis of Barrett's oesophagus and its associated squamous islands: a three-dimensional study of their morphological relationship with native oesophageal gland ducts. J Pathol 2005; 206(4):388-394

Del Buono R, Lee CY, Hawkey CJ, Wright NA. Isolated crypts form spheres prior to full intestinal differentiation when grown as xenografts: an in vivo model for the study of intestinal differentiation and crypt neogenesis, and for the abnormal crypt architecture of juvenile polyposis coli. J Pathol 2005; 206(4):395-401

Fang T-C, Alison MR, Cook HT, Jeffery R, Wright NA, Poulsom R. Proliferation of bone marrow-derived cells contributes to regeneration after folic acid-induced acute tubular injury. J Am Soc Nephrol 2005; 16(6):1723-1732

FitzGerald AJ, Mandir N, Goodlad RA. Leptin, cell proliferation and crypt fission in the gastrointestinal tract of intravenously fed rats. Cell Prolif 2005; 38(1):25-33

Kitchen PA, Goodlad RA, FitzGerald AJ, Mandir N, Ghatei MA, Bloom SR, Berlanga-Acosta J, Playford RJ, Forbes A, Walters JR. Intestinal growth in parenterally-fed rats induced by the combined effects of glucagon-like peptide 2 and epidermal growth factor. JPEN J Parenter Enteral Nutr 2005; 29(4):248-254

Lalani EN, Poulsom R, Stamp G, Fogt F, Thomas P, Nanji AA. Expression of hepatocyte growth factor and its receptor c-met, correlates with severity of pathological injury in experimental alcoholic liver disease. Int J Mol Med 2005; 15(5):811-817

Mandir N, FitzGerald AJ, Goodlad RA. Differences in the effects of age on intestinal proliferation, crypt fission and apoptosis on the small intestineand the colon of the rat. Int J Exp Pathol 2005; 86(2):125-130

Pollard P, Wortham N, Barclay E, Alam A, Elia G, Manek S, Poulsom R, Tomlinson I. Evidence of increased microvessel density and activation of the hypoxia pathway in turnours from the hereditary leiomyomatosis and renal cell cancer syndrome. J Pathol 2005; 205(1):41-49

Pollard PJ, Briere JJ, Alam NA, Barwell J, Barclay E, Wortham NC, Hunt T, Mitchell M, Olpin S, Moat SJ, Hargreaves IP, Heales SJ, Chung YL, Griffiths JR, Dalgleish A, McGrath JA, Gleeson MJ, Hodgson SV, Poulsom R, Rustin P, Tomlinson IPM. Accumulation of Krebs cycle intermediates and over-expression of HIF1 alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet 2005; 14(15):2231-2239

Wilson JM, Coletta PL, Cuthbert RJ, Scott N, MacLennan K, Hawcroft G, Leng L, Lubetsky JB, Jin KK, Lolis E, Medina F, Brieva JA, Poulsom R, Markham AF, Bucala R, Hull MA. Macrophage migration inhibitory factor promotes intestinal tumorigenesis. Gastroenterology 2005; 129(5):1485-1503

Yen T-H, Lai P-C, Chen C-C, Hsueh S, Huang J-Y. Renal involvement in patients with polymyositis and dermatomyositis. Int J Clin Pract 2005; 59(2):188-193

2004

Bashir O, FitzGerald AJ, Goodlad RA. Both suboptimal and elevated vitamin intake increase intestinal neoplasia and alter crypt fission in the Apc(Min/+) mouse. Carcinogenesis 2004; 25(8):1507-1515

Di Campli C, Piscaglia AC, Pierelli L, Rutella S, Bonanno G, Alison MR, Mariotti A, Vecchio FM, Nestola M, Monego G, Michetti F, Mancuso S, Pola P, Leone G, Gasbarrini G, Gasbarrini A. A human umbilical cord stem cell rescue therapy in a murine model of toxic liver injury. Dig Liver Dis 2004; 36(9):603-613

Direkze NC, Hodivala-Dilke K, Jeffery R, Hunt T, Poulsom R, Oukrif D, Alison MR, Wright NA. Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res 2004; 64(23):8492-8495

El-Bahrawy M, Poulsom R, Rowan AJ, Tomlinson IPM, Alison MR. Characterization of the E-cadherin/catenin complex in colorectal carcinoma cell lines. Int J Exp Pathol 2004; 85(2):65-74

Forbes SJ, Russo FP, Rey V, Burra P, Rugge M, Wright NA, Alison MR. A significant proportion of myofibroblasts are of bone marrow origin in human liver fibrosis. Gastroenterology 2004; 126(4):955-963

Howard A, Goodlad RA, Walters JRF, Ford D, Hirst BH. Increased expression of specific intestinal amino acid and peptide transporter mRNA in rats fed by TPN is reversed by GLP-2. J Nutr 2004; 134(11):2957-2964

Kelly P, Feakins R, Domizio P, Murphy J, Bevins C, Wilson J, Mcphail G, Poulsom R, Dhaliwal W. Paneth cell granule depletion in the human small intestine under infective and nutritional stress. Clin Exp Immunol 2004; 135(2):303-309

Knies-Bamforth UE, Fox SB, Poulsom R, Evan GI, Harris AL. c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer Res 2004; 64(18):6563-6570

Macharia R, Patel K, Otto WR, McKinnell IW, Christ B. Decamethonium bromide-mediated inhibition of embryonic muscle development. Anat Embryol 2004; 208(1):75-85

Morigi M, Imberti B, Zoja C, Corna D, Tomasoni S, Abbate M, Rottoli D, Angioletti S, Benigni A, Perico N, Alison M, Remuzzi G. Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 2004; 15(7):1794-1804

Sieber OM, Howarth KM, Thirlwell C, Rowan A, Mandir N, Goodlad RA, Gilkar A, Spencer-Dene B, Stamp G, Johnson V, Silver A, Yang H, Miller JH, Ilyas M, Tomlinson IPM. Myh deficiency enhances intestinal tumorigenesis in multiple intestinal neoplasia (Apc(Min/+)) mice. Cancer Res 2004; 64(24):8876-8881

Soriano-Izquierdo A, Gironella M, Massaguer A, May FEB, Salas A, Sans M, Poulsom R, Thim L, Pique JM, Panes JN. Trefoil peptide TFF2 treatment reduces VCAM-1 expression and leukocyte recruitment in experimental intestinal inflammation. J Leukoc Biol 2004; 75(2):214-223

Waddington SN, Nivsarkar MS, Mistry AR, Buckley SMK, Kemball-Cook G, Mosley KL, Mitrophanous K, Radcliffe P, Holder MV, Brittan M, Georgiadis A, Al-Allaf F, Bigger BW, Gregory LG, Cook HT, Ali RR, Thrasher A, Tuddenham EGD, Themis M, Coutelle C. Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy. Blood 2004; 104(9):2714-2721

Xia HH-X, Yang Y, Lam SK, Wong WM, Leung SY, Yuen ST, Elia G, Wright NA, Wong BC-Y. Aberrant epithelial expression of trefoil family factor 2 and mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation. J Clin Pathol 2004; 57(8):861-866

2003

Alison MR, Poulsom R, Otto WR, Vig P, Brittan M, Direkze NC, Preston SL, Wright NA. Plastic adult stem cells: will they graduate from the school of hard knocks? J Cell Sci 2003; 116(4):599-603

Allan GJ, Zannoni A, McKinnell I, Otto WR, Holzenberger M, Flint DJ, Patel K. Major components of the insulin-like growth factor axis are expressed early in chicken embryogenesis, with IGF binding protein (IGFBP)-5 expression subject to regulation by Sonic Hedgehog. Anat Embryol 2003; 207(1):73-84

Bashir O, Fitzgerald AJ, Berlanga-Acosta J, Playford RJ, Goodlad RA. Effect of epidermal growth factor administration on intestinal cell proliferation, crypt fission and polyp formation in multiple intestinal neoplasia (Min) mice. Clin Sci 2003; 105(3):323-330

Beck F, Chawengsaksophak K, Luckett J, Giblett S, Tucci J, Brown J, Poulsom R, Jeffery R, Wright NA. A study of regional gut endoderm potency by analysis of Cdx2 null mutant chimaeric mice. Dev Biol 2003; 255(2):399-406

Boot-Handford RP, Tuckwell DS, Plumb DA, Farrington Rock C, Poulsom R. A novel and highly conserved collagen (pro alpha 1(XXVII)) with a unique expression pattern and unusual molecular characteristics establishes a new clade within the vertebrate fibrillar collagen family. J Biol Chem 2003; 278(33):31067-31077

Direkze NC, Forbes SJ, Brittan M, Hunt T, Jeffery R, Preston SL, Poulsom R, Hodivala-Dilke K, Alison MR, Wright NA. Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-tranplanted mice. Stem Cells 2003; 21(5):514-520

El-Bahrawy M, El-Masry N, Alison M, Poulsom R, Fallowfield M. Expression of beta-catenin in basal cell carcinoma. Br J Dermatol 2003; 148(5):964-970

Kao RH, Francia G, Poulsom R, Hanby AM, Hart IR. Application of differential display, with in situ hybridization verification, to microscopic samples of breast cancer tissue. Int J Exp Pathol 2003; 84(5):207-212

Madsen B, Tarsounas M, Burchell JM, Hall D, Poulsom R, Taylor-Papadimitriou J. PLU-1, a transcriptional repressor and putative testis-cancer antigen, has a specific expression and localisation pattern during meiosis. Chromosoma 2003; 112(3):124-132

Novelli M, Cossu A, Oukrif D, Quaglia A, Lakhani S, Poulsom R, Sasieni P, Carta P, Contini M, Pasca A, Palmieri G, Bodmer W, Tanda F, Wright N. X-inactivation patch size in human female tissue confounds the assessment of tumor clonality. Proc Natl Acad Sci U S A 2003; 100(6):3311-3314

Olsburgh J, Harnden P, Weeks R, Smith B, Joyce A, Hall G, Poulsom R, Selby P, Southgate J. Uroplakin gene expression in normal human tissues and locally advanced bladder cancer. J Pathol 2003; 199(1):41-49

Poulsom R, Alison MR, Cook T, Jeffery R, Ryan E, Forbes SJ, Hunt T, Wyles S, Wright NA. Bone marrow stem cells contribute to healing of the kidney. J Am Soc Nephrol 2003; 14(6 Supp 1):S48-S54

Preston SL, Wong W-M, Chan AO-O, Poulsom R, Jeffery R, Goodlad RA, Mandir N, Elia G, Novelli M, Bodmer WF, Tomlinson IP, Wright NA. Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fission. Cancer Res 2003; 63(13):3819-3825

Sasaki M, FitzGerald AJ, Mandir N, Berlanga-Acosta J, Goodlad RA. Keratinocyte growth factor and epidermal growth factor can reverse the intestinal atrophy associated with elemental diets in mice. Exp Physiol 2003; 88(2):261-267

Sawyer EJ, Hanby AM, Poulsom R, Jeffery R, Gillett CE, Ellis IO, Ellis P, Tomlinson IPM. beta-catenin abnormalities and associated insulin-like growth factor overexpression are important in phyllodes tumours and fibroadenomas of the breast. J Pathol 2003; 200(5):627-632

Sawyer EJ, Poulsom R, Hunt FT, Jeffery R, Elia G, Ellis IO, Ellis P, Tomlinson IPM, Hanby AM. Malignant phyllodes tumours show stromal overexpression of c-myc and c-kit. J Pathol 2003; 200(1):59-64

Sullivan DC, Huminiecki L, Moore JW, Boyle JJ, Poulsom R, Creamer D, Barker J, Bicknell R. EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor. J Biol Chem 2003; 278(47):47079-47088

Taherzadeh O, Otto WR, Anand U, Nanchahal J, Anand P. Influence of human skin injury on regeneration of sensory neurons. Cell Tissue Res 2003; 312(3):275-280

Xia HHX, Lam SK, Wong WM, Hu WHC, Lai KC, Wong SH, Leung SY, Yuen ST, Wright NA, Wong BCY. Antralization at the edge of proximal gastric ulcers: Does Helicobacter pylori infection play a role? World J Gastroenterol 2003; 9(6):1265-1269

Yasuoka T, Sasaki M, Fukunaga T, Tsujikawa T, Fujiyama Y, Kushima R, Goodlad RA. The effects of lectins on indomethacin-induced small intestinal ulceration. Int J Exp Pathol 2003; 84(5):231-237

2002

Alison MR, Poulsom R, Forbes S, Wright NA. An introduction to stem cells. J Pathol 2002; 197(4):419-423

Alison MR, Poulsom R, Wright NA. Preface to stem cells. J Pathol 2002; 197(4):417-418

Arebi N, Healey ZV, Bliss PW, Ghatei M, Van Noorden S, Playford RJ, Calam J. Nitric oxide regulates the release of somatostatin from cultured gastric rabbit primary D-cells. Gastroenterology 2002; 123(2):566-576

Berlanga J, Prats P, Remirez D, Gonzalez R, Lopez-Saura P, Aguiar J, Ojeda M, Boyle JJ, Fitzgerald AJ, Playford RJ. Prophylactic use of epidermal growth factor reduces ischemia/reperfusion intestinal damage. Am J Pathol 2002; 161(2):373-379

Boettger AK, Till S, Chen AX, Anand U, Otto WR, Plumpton C, Trezise DJ, Tate SN, Bountra C, Coward K, Birch R, Anand P. Calcium-activated potassium channel SK1- and IK1-like immunoreactivity in injured human sensory neurones and its regulation by neurotrophic factors. Brain 2002; 125(Pt 2):252-263

Brittan M, Hunt T, Jeffery R, Poulsom R, Forbes SJ, Hodivala-Dilke K, Goldman J, Alison MR, Wright NA. Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon. Gut 2002; 50(6):752-757

Brown MA, Nicolai H, Howe K, Katagiri T, Lalani E-N, Simpson KJ, Manning NW, Deans A, Chen P, Khanna KK, Wati MR, Griffiths BL, Xu C-F, Stamp GWH, Solomon E. Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice. Transgenic Res 2002; 11(5):467-478

Crnogorac-Jurcevic T, Efthimiou E, Nielsen T, Loader J, Terris B, Stamp G, Baron A, Scarpa A, Lemoine NR. Expression profiling of microdissected pancreatic adenocarcinomas. Oncogene 2002; 21(29):4587-4594

Denzel A, Molinari M, Trigueros C, Martin JE, Velmurgan S, Brown S, Stamp G, Owen MJ. Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression. Mol Cell Biol 2002; 22(21):7398-7404

El-Bahrawy M, Talbot I, Poulsom R, Alison M. Variable nuclear localization of alpha-catenin in colorectal carcinoma. Lab Invest 2002; 82(9):1167-1174

El-Bahrawy MA, Talbot IC, Poulsom R, Jeffery R, Alison MR. The expression of E-cadherin and catenins in colorectal tumours from familial adenomatous polyposis patients. J Pathol 2002; 198(1):69-76

Ellis RD, Ashwood P, Powell JJ, Taylor PD, Poulsom R, Thompson RPH, Punchard NA. Selective binding of nucleotide probes by eosinophilic cationic protein during in situ hybridisation. Histochem J 2002; 34(3-4):153-160

FitzGerald AJ, Ghatei MA, Mandir N, Bloom SR, Iversen L, Goodlad RA. Effects of amidated gastrin and glycine-extended gastrin on cell proliferation and crypt fission in parenterally and orally fed rats. Digestion 2002; 66(1):58-66

Hardy RG, Brown RM, Miller SJ, Tselepis C, Morton DG, Jankowski JAZ, Sanders DSA. Transient P-cadherin expression in radiation proctitis: a model of mucosal injury and repair. J Pathol 2002; 197(2):194-200

Hardy RG, Tselepis C, Hoyland J, Wallis Y, Pretlow TP, Talbot I, Sanders DSA, Matthews G, Morton D, Jankowski JAZ. Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon. Gut 2002; 50(4):513-519

Hellawell GO, Turner GDH, Davies DR, Poulson R, Brewster SF, Macaulay VM. Expression of the type I insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. Cancer Res 2002; 62(10):2942-2950

Huminiecki L, Gorn M, Suchting S, Poulsom R, Bicknell R. Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. Genomics 2002; 79(4):547-552

Kelsall A, Fitzgerald AJ, Howard CV, Evans RC, Singh R, Rhodes JM, Goodlad RA. Dietary lectins can stimulate pancreatic growth in the rat. Int J Exp Pathol 2002; 83(4):203-208

Khan Z, MacDonald C, Wicks AC, Holt MP, Floyd D, Ghosh S, Wright NA, Playford RJ. Use of the 'nutriceutical', bovine colostrum, for the treatment of distal colitis: results from an initial study. Aliment Pharmacol Ther 2002; 16(11):1917-1922

Khan Z, Nair P, O'Shea C, Spiers N, Playford RJ, Wicks AC. Does Helicobacter pylori eradication reduce the long-term requirements for acid suppressants in patients with a history of peptic ulcer disease in general practice? Results from a four-year longitudinal study. Scand J Gastroenterol 2002; 37(2):144-147

Leonardsson G, Jacobs MA, White R, Jeffery R, Poulsom R, Milligan S, Parker M. Embryo transfer experiments and ovarian transplantation identify the ovary as the only site in which nuclear receptor interacting protein 1/RIP140 action is crucial for female fertility. Endocrinology 2002; 143(2):700-707

Madsen B, Spencer-Dene B, Poulsom R, Hall D, Lu PJ, Scott K, Shaw AT, Burchell JM, Freemont P, Taylor-Papadimitriou J. Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. Gene Expr Patterns 2002; 2:275-282

Madsen B, Spencer-Dene B, Poulsom R, Hall D, Lu PJ, Scott K, Shaw AT, Burchell JM, Freemont P, Taylor-Papadimitriou J. Characterisation and developmental expression of mouse Plu-1, a homologue of a human nuclear protein (PLU-1) which is specifically up-regulated in breast cancer. Mech Dev 2002; 119:S239-S246

Mubashar M, Harrington KJ, Chaudhary KS, Lalani E-N, Stamp GW, Sinnett D, Glass DM, Peters AM. Tc-99m-Sestamibi Imaging in the assessment of toremifene as a modulator of multidrug resistance in patients with breast cancer. J Nucl Med 2002; 43(4):519-525

Nanchahal J, Dover R, Otto WR. Allogeneic skin substitutes applied to burns patients. Burns 2002; 28(3):254-257

Petersen VC, Baxter KJ, Love SB, Shepherd NA. Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancer. Gut 2002; 51(1):65-69

Porter TR, Richards FM, Houlston RS, Evans DGR, Jankowski JA, Macdonald F, Norbury G, Payne SJ, Fisher SA, Tomlinson I, Maher ER. Contribution of cyclin d1 (CCND1) and E-cadherin (CDH1) polymorphisms to familial and sporadic colorectal cancer. Oncogene 2002; 21(12):1928-1933

Poulsom R, Alison MR, Forbes SJ, Wright NA. Adult stem cell plasticity. J Pathol 2002; 197(4):441-456

Robinson MJ, Tessier P, Poulsom R, Hogg N. The S100 family heterodimer, MRP-8/14, binds with high affinity to heparin and heparan sulfate glycosaminoglycans on endothelial cells. J Biol Chem 2002; 277(5):3658-3665

Sasaki M, Fitzgerald AJ, Grant G, Ghatei MA, Wright NA, Goodlad RA. Lectins can reverse the distal intestinal atrophy associated with elemental diets in mice. Aliment Pharmacol Ther 2002; 16(3):633-642

Sawyer EJ, Hanby AM, Rowan AJ, Gillett CE, Thomas RE, Poulsom R, Lakhani SR, Ellis IO, Ellis P, Tomlinson IPM. The Wnt pathway, epithelial-stromal interactions, and malignant progression in phyllodes tumours. J Pathol 2002; 196(4):437-444

Townsend PA, Dublin E, Hart IR, Kao R-H, Hanby AM, Cutress RI, Poulsom R, Ryder K, Barnes DM, Packham G. BAG-1 expression in human breast cancer: interrelationship between BAG-1 RNA, protein, HSC70 expression and clinico-pathological data. J Pathol 2002; 197(1):51-59

Tselepis C, Perry I, Dawson C, Hardy R, Darnton SJ, McConkey C, Stuart RC, Wright N, Harrison R, Jankowski JAZ. Tumour necrosis factor-alpha in Barrett's oesophagus: a potential novel mechanism of action. Oncogene 2002; 21(39):6071-6081

Turner KJ, Crew JP, Wykoff CC, Watson PH, Poulsom R, Pastorek J, Ratcliffe PJ, Cranston D, Harris AL. The hypoxia-inducible genes VEGF and CA9 are differentially regulated in superficial vs invasive bladder cancer. Br J Cancer 2002; 86(8):1276-1282

Wheeler JMD, Warren BF, Mortensen NJM, Kim HC, Biddolph SC, Elia G, Beck NE, Williams GT, Shepherd NA, Bateman AC, Bodmer WF. An insight into the genetic pathway of adenocarcinoma of the small intestine. Gut 2002; 50(2):218-223

Wong WM, Mandir N, Goodlad RA, Wong BCY, Garcia SB, Lam S-K, Wright NA. Histogenesis of human colorectal adenomas and hyperplastic polyps: the role of cell proliferation and crypt fission. Gut 2002; 50(2):212-217

Other Publications

Gutiérrez-González L, Wright NA. Biology of intestinal metaplasia in 2008: more than a simple phenotypic alteration. Dig Liver Dis 2008;40(7):510-22

Humphries A, Wright NA. Colonic crypt organization and tumorigenesis. Nat Rev Cancer 2008;8(6):415-24

Leedham SJ, Wright NA. Human tumour clonality assessment-flawed but necessary. J Pathol 2008;215(4):351-4

Leedham SJ, Wright NA. Expansion of a mutated clone: from stem cell to tumour. J Clin Pathol 2008; 61(2):164-171

Anand U. Mechanisms and management of cancer pain. In: Alison M (ed.) The Cancer Handbook, 2nd edition. London: John Wiley and Sons Ltd, 2007.

Andoh A, Bamba S, Brittan M, Fujiyama Y, Wright NA. Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut. Pharmacol Ther 2007; 114(1):94-106

Brittan M, Alison MR, Schier S, Wright NA. Bone marrow stem cell-mediated regeneration in IBD: Where do we go from here? Gastroenterology 2007; 132(3):1171-1173

Fellous TG, Guppy NJ, Brittan M, Alison MR. Cellular pathways to beta-cell replacement. Diabetes Metab Res Rev 2007; 23(2):87-99

Goodlad RA. Fiber can make your gut grow. Nutrition 2007; 23(5):434-435

Goodlad RA. Mouse models of cancer. In: Alison M (ed.) The Cancer Handbook, 2nd edition. London: John Wiley and Sons Ltd, 2007; 243-62.

Kallis YN, Alison M, Forbes SJ. Author's reply. Gut 2007; 56: 1640-1641.

Alison MR, Lovell MJ, Direkze NC, Wright NA, Poulsom R. Stem cell plasticity and tumour formation. Eur J Cancer 2006; 42(9):1247-1256

Alison MR, Poulsom R, Brittan M, Schier S, Burkert J, Wright NA. Isolation of gut SP cells does not automatically enrich for stem cells. Gastroenterology 2006; 130(3):1012-1013

Burkert J, Wright NA, Alison MR. Stem cells and cancer: an intimate relationship. J Pathol 2006; 209(3):287-297

Leedham SJ, Brittan M, Preston SL, McDonald SAC, Wright NA. The stomach periglandular fibroblast sheath: all present and correct. Gut 2006; 55(2):295-296

Leedham SJ, Jankowski J, Wright N, Tomlinson IPM. Genetics of inflammatory bowel disease and associated cancers. Curr Colorectal Cancer Rep 2006; 2:191-199

Malfertheiner P, Fass R, Quigley EMM, Modlin IM, Malagelada JR, Moss SF, Holtmann G, Goh K-L, Katelaris P, Stanghellini V, Talley NJ, Tytgat GN, Wright NA. From gastrin to gastro-oesophageal reflux disease: a century of acid suppression. Aliment Pharmacol Ther 2006; 23(6):683-690

McDonald SAC, Preston SL, Greaves LC, Leedham SJ, Lovell MA, Jankowski JAZ, Turnbull DM, Wright NA. Clonal expansion in the human gut: mitochondrial DNA mutati ons show us the way. Cell Cycle 2006; 5(8):808-811

McDonald SAC, Preston SL, Lovell MJ, Wright NA, Jankowski JAZ. Mechanisms of disease: from stem cells to colorectal cancer. Nat Clin Pract Gastroenterol Hepatol 2006; 3(5):267-274

Poulsom R, Prodromidi EI, Pusey CD, Cook HT. Cell therapy for renal regeneration-time for some joined-up thinking? Nephrol Dial Transplant 2006; 21(12):3349-3353

Wright NA. Review article: is there a common principle in the development of gastrointestinal cancers? Stem cells in the origin of cancer. Aliment Pharmacol Ther 2006; 24(Supp 4):31-40

Alison MR, Lovell M. Stem cells, master cells for all seasons: a primer. Galton Inst Newsl 2005; Issue 54(March):2-6

Alison MR, Lovell MJ. Liver cancer: the role of stem cells. Cell Prolif 2005; 38(6):407-421

Andoh A, Bamba S, Fujiyama Y, Brittan M, Wright NA. Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response. J Gastroenterol 2005; 40(12):1089-1099

Goodlad RA. Defective denominators. Gut 2005; 54(10):1502

Goodlad RA, Alferez D. Defective denominators - reply. Gut 2005; 54(10):1502-1503

Lee SY, Wang L-J, Yen T-H, Chang C-T. Transarterial embolization of ruptured angiomyolipoma associated with tuberous sclerosis. Nephrol Dial Transplant 2005; 20(8):1762-1763

Leedham SJ, Brittan M, McDonald SAC, Wright NA. Intestinal stem cells. J Cell Mol Med 2005; 9(1):11-24

Leedham SJ, Schier S, Thliveris AT, Halberg RB, Newton MA, Wright NA. From gene mutations to tumours: stem cells in gastrointesti nal carcinogenesis. Cell Prolif 2005; 38(6):387-405

Leedham SJ, Thliveris AT, Halberg RB, Newton MA, Wright NA. Gastrointestinal stem cells and cancer: bridging the molecular gap. Stem Cell Rev 2005; 1(3):233-242

Modlin IM, Sachs G, Wright N, Kidd M. Edkins and a century of acid suppression. Digestion 2005; 72(2-3):129-145

Otto WR, Thim L. Trefoil factor family-interacting proteins. Cell Mol Life Sci 2005; 62(24):2939-2946

Regalo G, Wright NA, Machado JC. Trefoil factors: from ulceration to neoplasia. Cell Mol Life Sci 2005; 62(24):2910-2915

Schier S, Wright NA. Stem cell relationships and the origin of gastrointestinal cancer. Oncology 2005; 69(Suppl 1):9-13

Wu H-H, Chang C-T, Yen T-H, Hung C-C. A case of adrenal aldosteronoma with horseshoe kidney and duplicated inferior vena cava. Nephrol Dial Transplant 2005; 20(12):2858-2860

Yen T-H, Chang C-T. Nutcracker phenomenon or nutcracker syndrome? - reply. Nephrol Dial Transplant 2005; 20(9):2009

Alison MR, Poulsom R, Otto WR, Vig P, Brittan M, Direkze NC, Lovell M, Fang TC, Preston SL, Wright NA. Recipes for adult stem cell plasticity: fusion cuisine or readymade? J Clin Pathol 2004; 57(2):113-120

Alison MR, Vig P, Russo F, Bigger BW, Amofah E, Themis M, Forbes S. Hepatic stem cells: from inside and outside the liver? Cell Prolif 2004; 37(1):1-21

Brittan M, Wright NA. Stem cell in gastrointestinal structure and neoplastic development. Gut 2004; 53(6):899-910

Brittan M, Wright NA. The gastrointestinal stem cell. Cell Prolif 2004; 37(1):35-53

Fang T-C, Alison MR, Wright NA, Poulsom R. Adult stem cell plasticity: will engineered tissues be rejected? Int J Exp Pathol 2004; 85(3):115-124

Otto WR, Rao J. Tomorrow's skeleton staff: mesenchymal stem cells and the repair of bone and cartilage. Cell Prolif 2004; 37(1):97-110

Roufosse CA, Direkze NC, Otto WR, Wright NA. Circulating mesenchymal stem cells. Int J Biochem Cell Biol 2004; 36(4):585-597

Wright N. Inflammation activates Apobec-1 and stabilizes multiple anti-apoptotic mRNAs. Gastroenterology 2004; 127(4):1259-1259

Alison MR. Characterization of the differentiation capacity of rat-derived hepatic stem cells. Semin Liver Dis 2003; 23(4):325-335

Fang T-C, Poulsom R. Cell-based therapies for birth defects: a role for adult stem cell plasticity? Birth Defects Res Part C Embryo Today 2003; 69:238-249

Poulsom R. Does bone marrow contain renal precursor cells? Nephron Exp Nephrol 2003; 93(2):e53-e57

Preston SL, Alison MR, Forbes SJ, Direkze NC, Poulsom R, Wright NA. The new stem cell biology: something for everyone. J Clin Pathol Mol Pathol 2003; 56(2):86-96

Rushton DH, Dover R, Norris MJ. Is there really no clear association between low serum ferritin and chronic diffuse telogen hair. Br J Dermatol 2003; 148(6):1282-1284

Alison MR, Hunt T, Forbes SJ. Minichromosome maintenance (MCM) proteins may be pre-cancer markers. Gut 2002; 50(3):290-291

Ashrafian H, Taylor-Robinson SD, Calam J, Playford RJ. Once you start, you just can't stop!. Lancet 2002; 359(9302):226

Brittan M, Wright NA. Gastrointestinal stem cells. J Pathol 2002; 197(4):492-509

Forbes S, Vig P, Poulsom R, Thomas H, Alison M. Hepatic stem cells. J Pathol 2002; 197(4):510-518

Forbes SJ, Poulsom R, Wright NA. Hepatic and renal differentiation from blood-borne stem cells. Gene Ther 2002; 9(10 Spec Is):625-630

Forbes SJ, Vig P, Poulsom R, Alison MR, Wright NA. Bone marrow-derived liver stem cells: their therapeutic potential. Gastroenterology 2002; 123(2):654-655

Forbes SJ, Vig P, Poulsom R, Wright NA, Alison MR. Adult stem cell plasticity: new pathways of tissue regeneration become visible. Clin Sci 2002; 103(4):355-369

Gribaldo L, Alison M, Andrews PW, Bremer S, Donovan PJ, Knaan-Shanzer S, Mertelsmann R, Spielmann H, Testa NG, Triffitt JT, Zipori D, de Wynter E. Meeting summary: European Workshop on Stem Cells, European Centre for the Validation of Biomedical Testing Methods, Institute for Health and Consumer Protection, Joint Research Centre, Ispra, Italy, November 21-23, 2001. Exp Hematol 2002; 30(7):628-633

Jankowski JA, Provenzale D, Moayyedi P. Esophageal adenocarcinoma arising from Barrett's metaplasia has regional variations in the West. Gastroenterology 2002; 122(2):588-590

Otto WR. Lung epithelial stem cells. J Pathol 2002; 197(4):527-535

Playford RJ. Homeobox genes: going for growth. Gut 2002; 50(4):447-448

Rushton DH, Dover R, Sainsbury AW, Norris MJ, Gilkes JJH, Ramsay ID. Iron deficiency is neglected in women's health. BMJ 2002; 325(7373):1176-1177

Wright NA, Poulsom R. Top down or bottom up? Competing management structures in the morphogenesis of colorectal neoplasms. Gut 2002; 51(3):306-308