Selected Publications

Martin C., Berridge G., Mistry P., Higgins C.F., Charlton P., and Callaghan R. (2000) "Communication between modulatory and transport drug interaction sites on P-glycoprotein." Molecular Pharmacology 58: 624-632.

Rosenberg M.F., Velarde G., Ford R.C., Martin C., Berridge G., Kerr I.D., Callaghan R., Schmidlin A., Wooding C., Linton K.J., and Higgins C.F. (2001) "Projection structure of an ABC transporter, the multidrug resistance P-glycoprotein, determined to 10A resolution by electron cryo-microscopy." EMBO J. 20:5615-5625.

Rothnie A., Theron D., Soceneantu L., Martin C., Traikia M., Berridge G., Higgins C., Deveaux P., and Callaghan R. (2001) "The importance of cholesterol to maintain activity of P-glycoprotein and modify its membrane perturbing influence." European J Biophysics 30:430-442.

Martin C., Higgins C.F. and Callaghan R. (2001) "The vinblastine binding site adopts high and low affinity conformations during a transport cycle of P-glycoprotein." Biochemistry 40:15733-15742.

Taylor A.M., Storm J., Soceneantu L., Linton K.J., Gabriel M., Martin C., Woodhouse J., Blott E., Higgins C.F. and Callaghan R. (2001) "Detailed characterisation of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild type protein." British Journal of Pharmacology 134:1609-1618.