Selected Publications

Murdoch C, Muthana M, Coffelt S and Lewis CE. The role of myeloid cells in the promotion of tumour angiogenesis. Nature Reviews Cancer 2008. (August edition; in press).

Muthana M, Scott SD, Farrow N, Morrow F, Murdoch C, Grubb S, Brown NJ, Dobson J and Lewis CE. A novel magnetic approach to enhance the efficacy of cell-based gene therapies. Gene Therapy 2008; 15(12): 902-910.

Pahler JC, Tazzyman S, Erez N, Chen YY, Murdoch C, Nozawa H, Lewis CE and Hanahan D. Plasticity in tumor-promoting inflammation: impairment of macrophage recruitment evokes a compensatory neutrophil response. Neoplasia 2008; 10: 329-340.

Larsen M, Tazzyman S, Lund E, Junker N, Lewis CE, Kristjansen PEG and Murdoch C. Hypoxia-induced secretion of macrophage migration inhibitory factor from MCF-7 breast cancer cells is regulated in a hypoxia-inducible factor-independent manner. Cancer Lett 2008; 265(2): 239-249.

Biswas SK, Sica A & Lewis CE. Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms. J Immunol 2008; 180:2011-2017.

De Palma M, Murdoch C, Venneri MA, Naldini L & Lewis CE. Tie2-expressing Monocytes: Regulation of Tumor Angiogenesis and Therapeutic Implications. Trends Immunol 2007; 28(12):545-50.

Lewis CE, De Palma M and Naldini L. Tie2-expressing Monocytes and Tumor Angiogenesis: Regulation by Hypoxia and Angiopoietin-2. Cancer Res 2007; 67(18):8429-32.

Murdoch C, Tazzyman S, Webster S and Lewis CE. Expression of Tie-2 by human monocytes and their responses to angiopoietin-2. J Immunol 2007; 178:7405-11.

Lewis CE and Hughes R. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2. Breast Cancer Research 2007; 9:209-213.

Staton CA, Stribbling SM, García-Echeverría C, Bury JP, Tazzyman S, Lewis CE and Brown NJ. Identification of key residues involved in mediating the in vivo anti-tumour/anti-endothelial activity of Alphastatin. J Thromb & Haemost 2007; 5:846-54.

Lewis CE & Pollard J. Function of macrophage subpopulations in distinct microenvironments of tumors. Cancer Res 2006; 66:605-12.

Bingle L, Lewis CE, Corke KP, Reed MW and Brown NJ. Macrophages promote angiogenesis in human breast tumour spheroids in vivo. Br J Cancer 2006; 94:101-7.

Ryan RM, Green J and Lewis CE. Use of bacteria in anti-cancer therapies. Bioessays 2006; 28:84-94.

Murdoch C, Muthana M and Lewis CE. Hypoxia regulates macrophage function in inflammation. J Immunol 2005; 175(10):6257-63.

Lewis CE and Murdoch C. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am J Pathol 2005; 167:627-635.

Murdoch C and Lewis CE. Macrophage migration and gene expression in response to tumour hypoxia. Int J Cancer 2005; 117(5):701-8.

Murdoch C, Giannoudis A and Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004; 104:2224-34.

Staton CA, Brown NJ, Rodgers GR, Corke KP, Tazzyman S, Underwood JCEU and Lewis CE. Alphastatin, a 24 amino acid fragment of human fibrinogen, is a potent new inhibitor of activated endothelial cells in vitro and in vivo. Blood 2004; 103:601-6.

Ameri K, Lewis CE, Raida M, Sowter H, Hai T and Harris AL. Anoxic induction of ATF-4 via HIF-1 independent pathways of protein stabilisation in human cancer cells. Blood 2004; 103: 1876-82.

Daly ME, Makris A, Reed M and Lewis CE. Hemostatic regulators of tumor angiogenesis: A source of anti-angiogenic agents for cancer treatment? J Natl Cancer Inst 2003; 95(22):1660-73.

Burke B, Giannoudis A, Corke KP, Gill D, Wells M, Ziegler-Heitbrock L and Lewis CE. Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am J Pathol 2003; 163(4):1233-43.

Bingle L, Brown NJ and Lewis CE. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol 2002; 196: 254-265.

Burke B, Tang N, Corke KP, Tazzyman D, Ameri K, Wells M and Lewis CE. Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J Pathol 2002; 196:204-12.

Hollander AP, Corke KP, Freemont AJ and Lewis CE. Expression of HIF-1alpha by macrophages in the rheumatoid synovium: implications for targeting therapeutic genes to the inflamed joint. Arthrtitis & Rheumat 2001; 4(7):1540-4.

Bootle-Wilbraham CA, Tazzyman S, Marshall JM and Lewis CE. Fibrinogen E-fragment inhibits the migration and tubule formation of human dermal microvascular endothelial cells in vitro. Cancer Res 2000; 60: 4719-24.

Lewis J, Landers R, Underwood JCE, Harris AL and Lewis CE. Expression of VEGF by macrophages is upregulated in avascular areas of breast carcinomas. J Pathol 2000; 192:150-8.

Griffiths L, Binley K, Iqball S, Kan O, Maxwell P, Lewis CE, Harris AL, Kingsman S. and Naylor S. The macrophage- a novel system to deliver gene therapy to pathological hypoxia. Gene Therapy 2000; 7:255-62.