Keith Caldecott
University of Sussex
Genome Damage and Stability Centre
Falmer
Brighton
BN1 9RQ
United Kingdom
Email: k.w.caldecott@sussex.ac.uk
Tel: 01273 877519
Web: Lab website
Scientific summary
Single-strand breaks (SSBs) are the commonest DNA lesions arising in cells which if not rapidly repaired can block transcription or generate clastogenic double-strand breaks during DNA replication.
Recent publications
PARP-3 and APLF Function Together to Accelerate Nonhomologous End-Joining
Mol Cell.2011;41 :33-45
A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage
Nature.2009;461 :674-678
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