Adele Murrell
Cambridge Research Institute
Robinson Way
Cambridge
CB2 0RE
United Kingdom
Email: amm207@cam.ac.uk
Scientific summary
The Insulin-like growth factor 2 (IGF2) is a well studied imprinted gene that is normally expressed from the paternal allele. DNA methylation, histone modification and secondary chromatin structure are the key components contributing to epigenetic gene regulation.
Recent publications
Generation of a genomic tiling array of the human Major Histocompatibility Complex (MHC) and its application for DNA methylation analysis
BMC Med Genomics.2008;1 :19
Cohesin Is Required for Higher-Order Chromatin Conformation at the Imprinted IGF2-H19 Locus
PLoS Genet.2009;5 :e1000739
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