Christine Farr
University of Cambridge
The Old School
Trinity Lane
Cambridge
CB2 1TN
United Kingdom
Email: c_farr@gen.cam.ac.uk
Scientific summary
Topo2 plays a major role in the removal of catenanes arising from DNA replication and is essential for efficient sister chromatid segregation. Since 2000 evidence has accumulated, both from S. cerevisiae and vertebrates, that topo2 is a target of SUMOylation.
Recent publications
Depletion of topoisomerase II alpha leads to shortening of the metaphase interkinetochore distance and abnormal persistence of PICH-coated anaphase threads
J Cell Sci.2007;120 :3952-3964
The organization and function of chromosomes - Workshop on chromosome structural elements: from DNA sequence to function
EMBO Rep.2006;7 :372-376
Increase text
Decrease text
Print this page